Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity.

[1]  E. Feskens,et al.  Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study , 1993, The Lancet.

[2]  W. Wahli,et al.  Peroxisome proliferator-activated receptors: finding the orphan a home , 1994, Molecular and Cellular Endocrinology.

[3]  Christopher K. Glass,et al.  The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation , 1998, Nature.

[4]  W. Wahli,et al.  Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions. , 1999, Current opinion in biotechnology.

[5]  A. Folsom,et al.  Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. , 1999, American journal of epidemiology.

[6]  J. Bilakovics,et al.  A Selective Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Modulator Blocks Adipocyte Differentiation but Stimulates Glucose Uptake in 3T3-L1 Adipocytes , 2000 .

[7]  Sander Kersten,et al.  Roles of PPARs in health and disease , 2000, Nature.

[8]  Michael Karin,et al.  Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ , 2001, Science.

[9]  E. van Nood,et al.  Flavonoids: a review of probable mechanisms of action and potential applications. , 2001, The American journal of clinical nutrition.

[10]  K. Miyashita,et al.  Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes. , 2002, FEBS letters.

[11]  Joseph L Evans,et al.  Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. , 2002, Endocrine reviews.

[12]  Y. Collan,et al.  Peroxisome proliferator-activated receptors (PPARs) in health and disease. , 2002, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.

[13]  M. Moreno-Aliaga,et al.  Effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (p,p'-DDT) on 3T3-L1 and 3T3-F442A adipocyte differentiation. , 2002, Biochemical pharmacology.

[14]  S. Kuo,et al.  Flavonoid structure affects the inhibition of lipid peroxidation in Caco-2 intestinal cells at physiological concentrations. , 2003, The Journal of nutrition.

[15]  U. Benatti,et al.  Interference in MTT cell viability assay in activated macrophage cell line. , 2003, Analytical biochemistry.

[16]  J. Reddy,et al.  PAT5A: A Partial Agonist of Peroxisome Proliferator-Activated Receptor γ Is a Potent Antidiabetic Thiazolidinedione Yet Weakly Adipogenic , 2003, Journal of Pharmacology and Experimental Therapeutics.

[17]  H. Mersmann,et al.  Effects of isomers of conjugated linoleic acid on porcine adipocyte growth and differentiation. , 2003, The Journal of nutritional biochemistry.

[18]  S. Shoelson,et al.  Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance , 2003, International Journal of Obesity.

[19]  M. Desai,et al.  Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.

[20]  P. Zimmet.  The burden of type 2 diabetes: are we doing enough? , 2003, Diabetes & Metabolism.

[21]  J. Wray,et al.  Peroxisome proliferator-activated receptors: a critical review on endogenous pathways for ligand generation. , 2003, Prostaglandins & other lipid mediators.

[22]  Effect of Extracts from Euonymus alatus Sieb.on Peripheral Glucose Uptake of Adipocytes , 2004 .

[23]  P. Salimath,et al.  Antidiabetic influence of quercetin in streptozotocin- induced diabetic rats , 2004 .

[24]  F. Gregoire,et al.  Peroxisome proliferator-activated receptors as attractive antiobesity targets. , 2004, Drug news & perspectives.

[25]  H. Kishida,et al.  Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice. , 2004, Biological & pharmaceutical bulletin.

[26]  J. González‐Gallego,et al.  Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats. , 2005, The Journal of nutrition.

[27]  S. Ko,et al.  Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice. , 2005, Journal of ethnopharmacology.

[28]  M. Kanter,et al.  Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. , 2005, Pharmacological research.

[29]  Z. Zuo,et al.  Physicochemical and structural characterization of quercetin-beta-cyclodextrin complexes. , 2005, Journal of pharmaceutical sciences.

[30]  G. Muscat,et al.  Halofenate Is a Selective Peroxisome Proliferator–Activated Receptor γ Modulator With Antidiabetic Activity , 2006, Diabetes.

[31]  Y. Chan,et al.  Nutrient Physiology , Metabolism , and Nutrient-Nutrient Interactions Differential Effects of Isoflavones , from Astragalus Membranaceus and Pueraria Thomsonii , on the Activation of PPAR a , PPAR g , and Adipocyte Differentiation In Vitro 1 – 3 , 2006 .

[32]  Clinical Study of Compound Ramulus Euonymi Decoction in Improving Insulin Resistance and Hemorheological Parameters of Hypertension Patients , 2007 .

[33]  H. Sakurai,et al.  Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method. , 2007, Biological & pharmaceutical bulletin.

[34]  Salicylates targeting insulin resistance , 2007 .

[35]  P. Urios,et al.  Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure , 2007, European journal of nutrition.

[36]  A. Saltiel,et al.  Obesity induces a phenotypic switch in adipose tissue macrophage polarization. , 2007, The Journal of clinical investigation.

[37]  J. González‐Gallego,et al.  The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. , 2007, European journal of pharmacology.