A Joint Location-Scale Test Improves Power to Detect Associated SNPs, Gene Sets, and Pathways

[1]  P. Visscher,et al.  Another Explanation for Apparent Epistasis , 2014 .

[2]  Frank Dudbridge,et al.  Gene-Environment Dependence Creates Spurious Gene-Environment Interaction , 2014, American journal of human genetics.

[3]  Melissa R. Miller,et al.  Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities , 2014, Human Genetics.

[4]  Taylor J. Maxwell,et al.  A Versatile Omnibus Test for Detecting Mean and Variance Heterogeneity , 2014, Genetic epidemiology.

[5]  Peter Kraft,et al.  Gene‐Environment Interactions in Cancer Epidemiology: A National Cancer Institute Think Tank Report , 2013, Genetic epidemiology.

[6]  Xiaofeng Zhu,et al.  What is the significance of difference in phenotypic variability across SNP genotypes? , 2013, American journal of human genetics.

[7]  Wei Q. Deng,et al.  Meta-analysis of SNPs involved in variance heterogeneity using Levene’s test for equal variances , 2013, European Journal of Human Genetics.

[8]  Peter Kraft,et al.  A Nonparametric Test to Detect Quantitative Trait Loci Where the Phenotypic Distribution Differs by Genotypes , 2013, Genetic epidemiology.

[9]  Henryk Maciejewski,et al.  Gene set analysis methods: statistical models and methodological differences , 2013, Briefings Bioinform..

[10]  Marco Marozzi,et al.  Nonparametric Simultaneous Tests for Location and Scale Testing: A Comparison of Several Methods , 2013, Commun. Stat. Simul. Comput..

[11]  Lei Sun,et al.  Robust and Powerful Tests for Rare Variants Using Fisher's Method to Combine Evidence of Association From Two or More Complementary Tests , 2013, Genetic epidemiology.

[12]  J. Lawless,et al.  Pooled Association Tests for Rare Genetic Variants: A Review and Some New Results , 2012, 1205.4079.

[13]  Elif F. Acar,et al.  A Generalized Kruskal–Wallis Test Incorporating Group Uncertainty with Application to Genetic Association Studies , 2012, Biometrics.

[14]  Zhaoxia Yu.  Family-based association tests using genotype data with uncertainty. , 2012, Biostatistics.

[15]  Michael R Knowles,et al.  Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis , 2012, Nature Genetics.

[16]  Jaeil Ahn,et al.  Testing gene-environment interaction in large-scale case-control association studies: possible choices and comparisons. , 2012, American journal of epidemiology.

[17]  Li-Ling Chuang,et al.  Approximated distributions of the weighted sum of correlated chi-squared random variables , 2012 .

[18]  Peter Kraft,et al.  Gene-environment interactions in genome-wide association studies: a comparative study of tests applied to empirical studies of type 2 diabetes. , 2012, American journal of epidemiology.

[19]  Scott C. Bell,et al.  Effect of Temperature on Cystic Fibrosis Lung Disease and Infections: A Replicated Cohort Study , 2011, PloS one.

[20]  M. Corey,et al.  A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis Genetic modifier studies , 2011, Pediatric pulmonology.

[21]  Fred A. Wright,et al.  Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2 , 2011, Nature Genetics.

[22]  P. Paré,et al.  Modulatory effect of the SLC9A3 gene on susceptibility to infections and pulmonary function in children with cystic fibrosis , 2011, Pediatric pulmonology.

[23]  M. Romero,et al.  Regulation of electroneutral NaCl absorption by the small intestine. , 2011, Annual review of physiology.

[24]  G. Abecasis,et al.  MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes , 2010, Genetic epidemiology.

[25]  Cornelia van Duijn,et al.  Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations , 2010, BMC Genetics.

[26]  Michael Boehnke,et al.  LocusZoom: regional visualization of genome-wide association scan results , 2010, Bioinform..

[27]  Paul M. Ridker,et al.  On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study , 2010, PLoS genetics.

[28]  Yurii S. Aulchenko,et al.  ProbABEL package for genome-wide association analysis of imputed data , 2010, BMC Bioinformatics.

[29]  Art B. Owen,et al.  Karl Pearson’s meta analysis revisited , 2009, 0911.3531.

[30]  Angelo J. Canty,et al.  A Genome-Wide Association Study Identifies a Novel Major Locus for Glycemic Control in Type 1 Diabetes, as Measured by Both A1C and Glucose , 2009, Diabetes.

[31]  H. Cordell.  Detecting gene–gene interactions that underlie human diseases , 2009, Nature Reviews Genetics.

[32]  Ashutosh Kumar Singh,et al.  The Role of the NHERF Family of PDZ Scaffolding Proteins in the Regulation of Salt and Water Transport , 2009, Annals of the New York Academy of Sciences.

[33]  Jun Zhu,et al.  A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies. , 2008, American journal of human genetics.

[34]  F. Dudbridge,et al.  Estimation of significance thresholds for genomewide association scans , 2008, Genetic epidemiology.

[35]  J. Ellen,et al.  Interactions between secondhand smoke and genes that affect cystic fibrosis lung disease. , 2008, JAMA.

[36]  M. Donowitz,et al.  Regulatory binding partners and complexes of NHE3. , 2007, Physiological reviews.

[37]  A. Hamosh,et al.  Heritability of lung disease severity in cystic fibrosis. , 2007, American journal of respiratory and critical care medicine.

[38]  Augustin Luna,et al.  snp.plotter: an R-based SNP/haplotype association and linkage disequilibrium plotting package , 2007, Bioinform..

[39]  A. Chakravarti,et al.  Relative contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis. , 2006, Gastroenterology.

[40]  Chia-Ding Hou,et al.  A simple approximation for the distribution of the weighted combination of non-independent or independent probabilities , 2005 .

[41]  C. Goss,et al.  Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosis. , 2004, American journal of respiratory and critical care medicine.

[42]  J. Kost,et al.  Combining dependent P-values , 2002 .

[43]  D. Schaid,et al.  Score tests for association between traits and haplotypes when linkage phase is ambiguous. , 2002, American journal of human genetics.

[44]  J. H. Moore,et al.  Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. , 2001, American journal of human genetics.

[45]  N. Laird,et al.  The family based association test method: strategies for studying general genotype–phenotype associations , 2001, European Journal of Human Genetics.

[46]  C. Scriver,et al.  The Metabolic and Molecular Bases of Inherited Disease, 8th Edition 2001 , 2001, Journal of Inherited Metabolic Disease.

[47]  N. Bradbury,et al.  E3KARP Mediates the Association of Ezrin and Protein Kinase A with the Cystic Fibrosis Transmembrane Conductance Regulator in Airway Cells* , 2000, The Journal of Biological Chemistry.

[48]  Sven Bergmann,et al.  Methods for testing association between uncertain genotypes and quantitative traits. , 2011, Biostatistics.

[49]  J. Gustafson,et al.  Cystic Fibrosis , 2009, Journal of the Iowa Medical Society.

[50]  H. Levene.  Robust tests for equality of variances , 1961 .