Simultaneous analysis of multiple T helper subsets in leprosy reveals distinct patterns of Th1, Th2, Th17 and Tregs markers expression in clinical forms and reactional events

[1]  S. Reed,et al.  Distinct Roles of Th17 and Th1 Cells in Inflammatory Responses Associated with the Presentation of Paucibacillary Leprosy and Leprosy Reactions , 2017, Scandinavian journal of immunology.

[2]  M. Franco,et al.  Immunohistochemical assessment of cell populations in leprosy-spectrum lesions and reactional forms. , 2017, Histology and histopathology.

[3]  Alpana Sharma,et al.  T helper cells in leprosy: An update. , 2017, Immunology letters.

[4]  S. Reed,et al.  The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy , 2017, Infectious Diseases of Poverty.

[5]  Manoj Patidar,et al.  Interleukin 15: A key cytokine for immunotherapy. , 2016, Cytokine & growth factor reviews.

[6]  B. Bloom,et al.  Mechanisms of Defense against Intracellular Pathogens Mediated by Human Macrophages , 2016, Microbiology spectrum.

[7]  A. P. Vieira,et al.  Development of Type 2, But Not Type 1, Leprosy Reactions is Associated with a Severe Reduction of Circulating and In situ Regulatory T-Cells. , 2016, The American journal of tropical medicine and hygiene.

[8]  V. Ramesh,et al.  Leprosy Reactions Show Increased Th17 Cell Activity and Reduced FOXP3+ Tregs with Concomitant Decrease in TGF-β and Increase in IL-6 , 2016, PLoS neglected tropical diseases.

[9]  D. Mitra,et al.  Reciprocity between Regulatory T Cells and Th17 Cells: Relevance to Polarized Immunity in Leprosy , 2016, PLoS neglected tropical diseases.

[10]  B. Jabri,et al.  IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction , 2015, Nature Reviews Immunology.

[11]  P. Steinmann,et al.  Current knowledge on Mycobacterium leprae transmission: a systematic literature review. , 2015, Leprosy review.

[12]  J. R. de Sousa,et al.  New immunologic pathways in the pathogenesis of leprosy: role for Th22 cytokines in the polar forms of the disease. , 2015, Journal of the American Academy of Dermatology.

[13]  S. Horvath,et al.  IL-32 is a molecular marker of a host defense network in human tuberculosis , 2014, Science Translational Medicine.

[14]  M. Abdallah,et al.  Serum Th17 cytokines in leprosy: correlation with circulating CD4+ CD25highFoxP3+ T-regs cells, as well as down regulatory cytokines , 2014, Archives of Dermatological Research.

[15]  T. Ottenhoff,et al.  T-Cell Regulation in Lepromatous Leprosy , 2014, PLoS neglected tropical diseases.

[16]  V. Ramesh,et al.  Increase in TGF-β Secreting CD4+CD25+ FOXP3+ T Regulatory Cells in Anergic Lepromatous Leprosy Patients , 2014, PLoS neglected tropical diseases.

[17]  L. Câmara,et al.  Increased Frequency of CD4 and CD8 Regulatory T Cells in Individuals under 15 Years with Multibacillary Leprosy , 2013, PloS one.

[18]  V. Ramesh,et al.  CD4+ Th17 Cells Discriminate Clinical Types and Constitute a Third Subset of Non Th1, Non Th2 T Cells in Human Leprosy , 2013, PLoS neglected tropical diseases.

[19]  A. Geluk.  Challenges in immunodiagnostic tests for leprosy. , 2013, Expert opinion on medical diagnostics.

[20]  U. Sengupta,et al.  Increased Serum Circulatory Levels of Interleukin 17F in Type 1 Reactions of Leprosy , 2012, Journal of Clinical Immunology.

[21]  C. Akdis,et al.  TH17 and TH22 cells: a confusion of antimicrobial response with tissue inflammation versus protection. , 2012, The Journal of allergy and clinical immunology.

[22]  P. Haslett,et al.  Lessons of leprosy: the emergence of TH17 cytokines during type II reactions (ENL) is teaching us about T-cell plasticity. , 2012, Journal of drugs in dermatology : JDD.

[23]  G. Garlet,et al.  Expression analysis of wound healing genes in human periapical granulomas of progressive and stable nature. , 2012, Journal of endodontics.

[24]  D. Campbell,et al.  Phenotypical and functional specialization of FOXP3+ regulatory T cells , 2011, Nature Reviews Immunology.

[25]  R. Sabat,et al.  Biology of interleukin-22 , 2010, Seminars in Immunopathology.

[26]  J. Magarian Blander,et al.  T helper 17 cells: discovery, function, and physiological trigger , 2010, Cellular and Molecular Life Sciences.

[27]  D. Lockwood,et al.  Towards understanding the pathology of erythema nodosum leprosum. , 2008, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[28]  Diana J L Williams,et al.  The Continuing Challenges of Leprosy , 2006, Clinical Microbiology Reviews.

[29]  R. Roguet,et al.  The Use of Standardized Human Skin Models for Cutaneous Pharmacotoxicology Studies , 2002, Skin Pharmacology and Physiology.

[30]  R. Modlin.  Learning from Leprosy: Insights into Contemporary Immunology from an Ancient Disease , 2001, Skin Pharmacology and Physiology.

[31]  V. Ramesh,et al.  Monocyte derived IL 10 and PGE2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy. , 1995, Immunology letters.

[32]  V. Ramesh,et al.  Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae. , 1995, Immunology.

[33]  M. Gately,et al.  IL-12 regulates T helper type 1 cytokine responses in human infectious disease. , 1994, Journal of immunology.

[34]  T. Ottenhoff,et al.  Definition of a human suppressor T-cell epitope. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[35]  R L Modlin,et al.  Th1-Th2 paradigm: insights from leprosy. , 1994, The Journal of investigative dermatology.

[36]  B. Bloom,et al.  Cytokine patterns of immunologically mediated tissue damage. , 1992, Journal of immunology.

[37]  T. Ottenhoff,et al.  Regulation of Mycobacterial Heat‐Shock Protein‐Reactive T Cells by HLA Class II Molecules: Lessons from Leprosy , 1991, Immunological reviews.

[38]  S. Brett,et al.  Use of synthetic glycoconjugates containing the Mycobacterium leprae specific and immunodominant epitope of phenolic glycolipid I in the serology of leprosy. , 1986, Clinical and experimental immunology.

[39]  Ridley Ds,et al.  Classification of leprosy according to immunity. A five-group system. , 1966 .

[40]  A. Iyer,et al.  Advances in leprosy immunology and the field application: A gap to bridge. , 2016, Clinics in dermatology.

[41]  V. Valluri,et al.  Immunology of leprosy and diagnostic challenges. , 2015, Clinics in dermatology.

[42]  R. Modlin,et al.  Cytokine patterns at the site of mycobacterial infection. , 1994, Immunobiology.

[43]  B. Bloom,et al.  Genetically restricted suppressor T-cell clones derived from lepromatous leprosy lesions , 1986, Nature.