miRNA control of tumor cell invasion and metastasis

MicroRNAs have emerged as a novel class of noncoding RNAs that regulate gene expression at the post‐translational level in almost every biological event. A large body of evidence indicates that microRNAs regulate the expression of different genes that play an important role in cancer cell invasion, migration and metastasis. In this review, we briefly describe the role of various miRNAs in invasion, migration and metastasis which are essential steps during cancer progression.

[1]  S. Alahari,et al.  ST14 (Suppression of Tumorigenicity 14) Gene Is a Target for miR-27b, and the Inhibitory Effect of ST14 on Cell Growth Is Independent of miR-27b Regulation* , 2009, The Journal of Biological Chemistry.

[2]  S. Alahari,et al.  Molecular mechanisms controlling E-cadherin expression in breast cancer. , 2009, Biochemical and biophysical research communications.

[3]  P. Sun,et al.  MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells. , 2009, Biochemical and biophysical research communications.

[4]  Robert A. Weinberg,et al.  A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis , 2009 .

[5]  H. Kung,et al.  microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs , 2009, Brain Research.

[6]  Paula D. Bos,et al.  Metastasis: from dissemination to organ-specific colonization , 2009, Nature Reviews Cancer.

[7]  G. Blumenstock,et al.  Prognostic value and therapeutic consequences of vascular invasion in non-small cell lung carcinoma. , 2009, Lung cancer.

[8]  Jun Du,et al.  BMP-6 inhibits microRNA-21 expression in breast cancer through repressing δEF1 and AP-1 , 2009, Cell Research.

[9]  M. Daidone,et al.  miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon. , 2009, Cancer research.

[10]  S. Dangi‐Garimella,et al.  Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let‐7 , 2009, The EMBO journal.

[11]  Kedar S Vaidya,et al.  Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis. , 2009, Cancer research.

[12]  D. Polsky,et al.  Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor , 2009, Proceedings of the National Academy of Sciences.

[13]  Haifan Lin,et al.  MicroRNAs: key regulators of stem cells , 2009, Nature Reviews Molecular Cell Biology.

[14]  C. Bracken,et al.  The role of microRNAs in metastasis and epithelial-mesenchymal transition , 2009, Cellular and Molecular Life Sciences.

[15]  Jan-Fang Cheng,et al.  Dicer, Drosha, and outcomes in patients with ovarian cancer. , 2008, The New England journal of medicine.

[16]  S. Varambally,et al.  Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer , 2008, Science.

[17]  S. Dhanasekaran,et al.  Repression of E-cadherin by the polycomb group protein EZH2 in cancer , 2008, Oncogene.

[18]  G. Condorelli,et al.  Role of microRNAs in haemopoiesis, heart hypertrophy and cancer. , 2008, Biochemical Society transactions.

[19]  Kaleb M. Pauley,et al.  MicroRNAs and Their Emerging Roles in Immunology , 2008, Annals of the New York Academy of Sciences.

[20]  Shu Zheng,et al.  MicroRNA‐183 regulates Ezrin expression in lung cancer cells , 2008, FEBS letters.

[21]  Anna M. Krichevsky,et al.  miR-21: a small multi-faceted RNA , 2008, Journal of cellular and molecular medicine.

[22]  Hailong Wu,et al.  Suppression of cell growth and invasion by miR-205 in breast cancer , 2008, Cell Research.

[23]  Domenico Coppola,et al.  MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA , 2008, Molecular and Cellular Biology.

[24]  Qihong Huang,et al.  Small-molecule inhibitors of microrna miR-21 function. , 2008, Angewandte Chemie.

[25]  G. Nuovo,et al.  MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. , 2008, Biochemical and biophysical research communications.

[26]  M. Korpal,et al.  The emerging role of miR-200 family of MicroRNAs in epithelial-mesenchymal transition and cancer metastasis , 2008, RNA biology.

[27]  T. Wurdinger,et al.  MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators , 2008, Molecular and Cellular Biology.

[28]  S. Cohen,et al.  microRNAs in neurodegeneration , 2008, Current Opinion in Neurobiology.

[29]  G. Goodall,et al.  The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 , 2008, Nature Cell Biology.

[30]  Paul Ahlquist,et al.  MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins , 2008, Proceedings of the National Academy of Sciences.

[31]  Sun-Mi Park,et al.  The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. , 2008, Genes & development.

[32]  Lin Zhang,et al.  The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis , 2008, Nature Cell Biology.

[33]  W. Gerald,et al.  Endogenous human microRNAs that suppress breast cancer metastasis , 2008, Nature.

[34]  R. Weinberg,et al.  Tumour invasion and metastasis initiated by microRNA-10b in breast cancer , 2007, Nature.

[35]  F. Slack,et al.  The let-7 microRNA represses cell proliferation pathways in human cells. , 2007, Cancer research.

[36]  K. Ghoshal,et al.  MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. , 2007, Gastroenterology.

[37]  W. Filipowicz,et al.  Repression of protein synthesis by miRNAs: how many mechanisms? , 2007, Trends in cell biology.

[38]  Miguel Vicente-Manzanares,et al.  Cell migration at a glance , 2005, Journal of Cell Science.

[39]  Jeffrey Wyckoff,et al.  Cell migration in tumors. , 2005, Current opinion in cell biology.

[40]  J. Wrana,et al.  Signaling and endocytosis: a team effort for cell migration. , 2005, Developmental cell.

[41]  H. Horvitz,et al.  MicroRNA expression profiles classify human cancers , 2005, Nature.

[42]  C. Burge,et al.  Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets , 2005, Cell.

[43]  M. Rubin,et al.  Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. , 2003, Journal of the National Cancer Institute.