The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2

Hu et al. demonstrate that, independent of other countercurrents, TRIC-A and TRIC-B differentially modulate RyR2 gating. Results also suggest that TRIC-A and TRIC-B are permeable to both K+ and Cl−, thus enabling them to provide adaptable countercurrents for many cell types.

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