Treatment of malignant rhabdoid tumors of the head and neck with combined chemotherapy and 125I particle implantation

The malignant rhabdoid tumor (MRT) was originally described as a highly malignant variant of Wilms’ tumor in 1978 and was designated as a distinct entity in 1981. This highly aggressive tumor is characterized by its rhabdoid feature and biallelic loss of SMARCB1/INI1/hSNF5. The prognosis is very poor with only 31% of patients surviving to 1 year, and there are no standardized treatment strategies available.

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