论文信息 - Problems and pitfalls in ototoxicity testing.

Problems and pitfalls in ototoxicity testing.

A local anaesthetic drug under development, intended for use in ear surgery, was tested with regard to adverse, ototoxic effects. Inner ear damage was not obvious. However, in the guinea pig a massive formation of new bone occurred in the middle ear (bulla tympanica) within 5 weeks after a single local administration of the drug.

M. Anniko

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