Appendicular Skeletal Muscle Mass Reference Values and the Peak Muscle Mass to Identify Sarcopenia among Iranian Healthy Population

Background: Sacopenia is a common problem in elderly with the adverse outcomes. The objective of this study was to estimate the peak appendicular skeletal muscle mass (ASM) and age of its attainment by sex among the Iranian population. Methods: A total of 691 men and women aged 18–94 years participated in this cross-sectional, population-based study in Bushehr, Iran. ASM was measured by dual X-ray absorptiometry. Cutoff points for men and women were established considering two standard deviations (SDs) below the mean values of the skeletal muscle index (SMI) for young reference groups. The relationship between ASM and age was described by the second-degree regression models. Two SDs below the mean SMIs of reference groups were as cutoff values of low muscle mass in Iranian population. Results: The peak ASM values were 21.35 ± 0.12 Kg and 13.68 ± 0.10 Kg, and the age at peak ASM were 26 (24–28) years and 34 (33–35) years for men and women, respectively. Mean and SD of SMI in those ages were 7.01 ± 0.02 Kg/m2 and 5.44 ± 0.02 Kg/m2 among men and women, respectively. Calculated cutoff values of low muscle mass among the Iranian population were 7.0 Kg/m2 and 5.4 Kg/m2 among men and women, respectively. Conclusions: Iranian reference values of SMI for both genders were similar to Asia Working Group for Sarcopenia recommendation and lower than the United States and European values. Further studies from different nations and the Middle East countries are needed to obtain reference values for populations, enabling the researchers for comparison and also more valid reports on sarcopenia prevalence.

[1]  R. Heshmat,et al.  Sarcopenia and its associated factors in Iranian older individuals: Results of SARIR study. , 2016, Archives of gerontology and geriatrics.

[2]  C. Cooper,et al.  Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS) , 2015, BMC Geriatrics.

[3]  J. Reginster,et al.  Quality of life and physical components linked to sarcopenia: The SarcoPhAge study , 2015, Experimental Gerontology.

[4]  Y. Ha,et al.  The Reference Value of Skeletal Muscle Mass Index for Defining the Sarcopenia of Women in Korea , 2015, Journal of bone metabolism.

[5]  O. Bruyère,et al.  Estimation of sarcopenia prevalence using various assessment tools , 2015, Experimental Gerontology.

[6]  I. Shin,et al.  The application of different appendicular skeletal muscle cutoff points and research definitions associated with health-related quality of life in Korean older people: data from KNHANES 2008–2011 , 2014, BMC Geriatrics.

[7]  Jeffrey R Stout,et al.  Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS) , 2014, Age and ageing.

[8]  É. A. Silveira,et al.  Applicability and agreement of different diagnostic criteria for sarcopenia estimation in the elderly. , 2014, Archives of gerontology and geriatrics.

[9]  N. Tandon,et al.  Assessment of lean (muscle) mass and its distribution by dual energy X-ray absorptiometry in healthy Indian females , 2014, Archives of Osteoporosis.

[10]  L. Peng,et al.  Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. , 2014, Journal of the American Medical Directors Association.

[11]  J. Pasco,et al.  Total and Appendicular Lean Mass Reference Ranges for Australian Men and Women: The Geelong Osteoporosis Study , 2014, Calcified Tissue International.

[12]  Ming-Hsien Lin,et al.  Comparisons of sarcopenia defined by IWGS and EWGSOP criteria among older people: results from the I-Lan longitudinal aging study. , 2013, Journal of the American Medical Directors Association.

[13]  S. Giannini,et al.  Prevalence of sarcopenia based on different diagnostic criteria using DEXA and appendicular skeletal muscle mass reference values in an Italian population aged 20 to 80. , 2013, Journal of the American Medical Directors Association.

[14]  M. Cesari,et al.  Mortality as an adverse outcome of sarcopenia , 2013, The journal of nutrition, health & aging.

[15]  R. Heshmat,et al.  Sarcopenia and its determinants among Iranian elderly (SARIR): study protocol , 2012, Journal of Diabetes & Metabolic Disorders.

[16]  Andrea Russo,et al.  Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study. , 2012, Clinical nutrition.

[17]  Yong-jun Choi,et al.  Prevalence of sarcopenia and sarcopenic obesity in the Korean population based on the Fourth Korean National Health and Nutritional Examination Surveys. , 2012, The journals of gerontology. Series A, Biological sciences and medical sciences.

[18]  M. Narici,et al.  Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort , 2012, AGE.

[19]  E. Sacanella,et al.  Prevalence of sarcopenia in healthy community-dwelling elderly in an urban area of Barcelona (Spain) , 2012, The journal of nutrition, health & aging.

[20]  Luigi Ferrucci,et al.  Sarcopenia with limited mobility: an international consensus. , 2011, Journal of the American Medical Directors Association.

[21]  I. Tabata,et al.  A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors , 2010, European Journal of Applied Physiology.

[22]  S. Heymsfield,et al.  Dual Energy X-Ray Absorptiometry Body Composition Reference Values from NHANES , 2009, PloS one.

[23]  P. Ritz,et al.  Prevalence of sarcopenia in the French senior population , 2008, The journal of nutrition, health & aging.

[24]  Tamara B Harris,et al.  Alternative Definitions of Sarcopenia, Lower Extremity Performance, and Functional Impairment with Aging in Older Men and Women , 2007, Journal of the American Geriatrics Society.

[25]  R. Ross,et al.  Linking age-related changes in skeletal muscle mass and composition with metabolism and disease. , 2005, The journal of nutrition, health & aging.

[26]  S. Fujita,et al.  Muscle tissue changes with aging , 2004, Current opinion in clinical nutrition and metabolic care.

[27]  R. Ross,et al.  Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. , 2004, American journal of epidemiology.

[28]  S. Rubin,et al.  Sarcopenia: Alternative Definitions and Associations with Lower Extremity Function , 2003, Journal of the American Geriatrics Society.

[29]  E. Barrett-Connor,et al.  Sarcopenia in elderly men and women: the Rancho Bernardo study. , 2003, American journal of preventive medicine.

[30]  Robert Ross,et al.  Low Relative Skeletal Muscle Mass (Sarcopenia) in Older Persons Is Associated with Functional Impairment and Physical Disability , 2002, Journal of the American Geriatrics Society.

[31]  S. Heymsfield,et al.  Epidemiology of sarcopenia among the elderly in New Mexico. , 1998, American journal of epidemiology.

[32]  R N Pierson,et al.  Appendicular skeletal muscle mass: effects of age, gender, and ethnicity. , 1997, Journal of applied physiology.

[33]  Han-min Zhu,et al.  A cross-sectional study of loss of muscle mass corresponding to sarcopenia in healthy Chinese men and women: reference values, prevalence, and association with bone mass , 2013, Journal of Bone and Mineral Metabolism.

[34]  J. Baeyens,et al.  European working group on sarcopenia in older people. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people , 2010 .