Target probability affects the likelihood that a P300 will be generated in response to a target stimulus, but not its amplitude.

The ensemble-averaged P300 amplitude is affected by global and local target probability and interstimulus interval. We hypothesize that the local target probability-induced amplitude changes arise from a failure to consistently produce a P300 rather than producing lower amplitude responses. Single-trial analysis was conducted on auditory P300 data from 13 healthy subjects to determine the absence or presence of a P300 component for each target response separately. Selective, normalized averages were computed for each local target probability. Target stimuli preceded by one or two nontargets led to significantly more trials lacking a P300 than the other local target probability categories. The amplitudes of the responsive trials did not differ between the local target probability categories. This suggests that local target probability affects the consistency with which a subject responds to target stimuli, but not the P300 amplitude.

[1]  J Anderson,et al.  Classification of single-trial ERP sub-types: application of globally optimal vector quantization using simulated annealing. , 1995, Electroencephalography and clinical neurophysiology.

[2]  S A Hillyard,et al.  Selective attention and the auditory vertex potential. I. Effects of stimulus delivery rate. , 1976, Electroencephalography and clinical neurophysiology.

[3]  B.H. Jansen,et al.  Development and evaluation of the piecewise Prony method for evoked potential analysis , 2000, IEEE Transactions on Biomedical Engineering.

[4]  N. Squires,et al.  The effect of stimulus sequence on the waveform of the cortical event-related potential. , 1976, Science.

[5]  W. Sommer,et al.  Stimulus presentation rate dissociates sequential effects in event-related potentials and reaction times. , 1993, Psychophysiology.

[6]  E. Donchin,et al.  Is the P300 component a manifestation of context updating? , 1988, Behavioral and Brain Sciences.

[7]  E Gordon,et al.  Is the target-to-target interval a critical determinant of P3 amplitude? , 1999, Psychophysiology.

[8]  J. Polich.  Probability and inter-stimulus interval effects on the P300 from auditory stimuli. , 1990, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[9]  D L Woods,et al.  Recovery cycles of event-related potentials in multiple detection tasks. , 1980, Electroencephalography and clinical neurophysiology.

[10]  J. Polich,et al.  P300, global probability, and stimulus sequence effects in children , 1992 .

[11]  J Röschke,et al.  A replication study on P300 single trial analysis in schizophrenia: confirmation of a reduced number of 'true positive' P300 waves. , 2000, Journal of psychiatric research.

[12]  W. Pritchard.  Psychophysiology of P300. , 1981, Psychological bulletin.

[13]  C. Gonsalvez,et al.  Target-to-target interval versus probability effects on P300 in one- and two-tone tasks. , 2003, Psychophysiology.

[14]  Evian Gordon,et al.  Eeg alpha phase at stimulus onset significantly affects the amplitude of the P3 ERP component , 1998 .

[15]  Evian Gordon,et al.  Numbers of preceding nontargets differentially affect responses to targets in normal volunteers and patients with schizophrenia: A study of event-related potentials , 1995, Psychiatry Research.

[16]  A Pfefferbaum,et al.  Expectancy for events in old age: stimulus sequence effects on P300 and reaction time. , 1982, Journal of gerontology.

[17]  T W Picton,et al.  Temporal and sequential probability in evoked potential studies. , 1981, Canadian journal of psychology.

[18]  J. Polich,et al.  P300 amplitude is determined by target-to-target interval. , 2002, Psychophysiology.

[19]  E. Donchin,et al.  On quantifying surprise: the variation of event-related potentials with subjective probability. , 1977, Psychophysiology.

[20]  John Polich,et al.  P300 Sequence Effects, Probability, and Interstimulus Interval , 1997, Physiology & Behavior.

[21]  E Donchin,et al.  Sequential expectancies and decision making in a changing environment: an electrophysiological approach. , 1982, Psychophysiology.

[22]  J. Polich,et al.  P300 from auditory and somatosensory stimuli: probability and inter-stimulus interval. , 1991, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[23]  T W Picton,et al.  The P300 Wave of the Human Event‐Related Potential , 1992, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[24]  Emanuel Donchin,et al.  The P300 component of the event-related brain potential as an index of information processing , 1982, Biological Psychology.

[25]  J. Polich,et al.  P300, probability, and interstimulus interval. , 1990, Psychophysiology.