[Rehabilitation of lesions in the visual pathways].

This review considers diseases of the visual pathways at different levels, their consequences for relevant everyday functions and their rehabilitation. Infrachiasmatic lesions are mostly associated with central or ring scotomas causing reading problems. The use of an eccentric fixation locus in combination with text magnification often allows the patient to maintain reading ability. Chiasmatic lesions can cause orientation disability by bitemporal hemianopia and reading problems by slide phenomena along the vertical midline. Suprachiasmatic lesions lead to homonymous visual field defects. Regarding the hemianopic orientation disorder, there are two different training approaches, which have been discussed controversially: restitution of the visual field by visual stimulation versus compensation by explorative eye movements towards the hemianopic side. Previously described positive effects of exploration training were not entirely convincing due to the lack of control groups. A new randomised and controlled study has proved the effectiveness of exploration training and showed that the patients apply the improved exploration strategy to everyday life. In the control group, which received a visual field stimulation training--a potential restitution training--neither exploration nor visual fields changed. The hemianopic reading disorder depends on the distance of the field defect from the centre, i. e., the size of the reading visual field, the side of the field defect in regard to the reading direction and the presence of spontaneous adaptive strategies, such as eccentric fixation or predictive saccades. Specific reading training can be helpful. Cerebral visual impairments with visual field defects are often associated with disorders of information processing in higher cortical areas. These complex disorders usually require an interdisciplinary rehabilitation. Specific examination methods to assess functions of everyday relevance and their use as a basis for rehabilitation measures are discussed. Visual rehabilitation can be very successful in many cases and improves the patients' quality of life. One should expect that the demand for neuro-ophthalmological rehabilitation will increase, because the survival rate after severe cerebral lesions and the general lifespan are rising.

[1]  J. Kevin O’Regan,et al.  The control of saccade size and fixation duration in reading: The limits of linguistic control , 1980, Perception & psychophysics.

[2]  J Zihl,et al.  Visual field rehabilitation in the cortically blind? , 1986, Journal of neurology, neurosurgery, and psychiatry.

[3]  S. Trauzettel-Klosinski,et al.  Eye movements in reading with hemianopic field defects: the significance of clinical parameters , 1998, Graefe's Archive for Clinical and Experimental Ophthalmology.

[4]  A. Skoczenski,et al.  Recent advances in cortical visual impairment , 2001, Developmental medicine and child neurology.

[5]  J. Zihl,et al.  Visual scanning behavior in patients with homonymous hemianopia , 1995, Neuropsychologia.

[6]  J. O'regan,et al.  Is there a systematic location for the pseudo-fovea in patients with central scotoma? , 1993, Vision Research.

[7]  Daniel B Hier,et al.  Recovery of behavioral abnormalities after right hemisphere stroke , 1983, Neurology.

[8]  G. McConkie,et al.  Asymmetry of the perceptual span in reading , 1976 .

[9]  Yaffa Yeshurun,et al.  Covert attention increases spatial resolution with or without masks: support for signal enhancement. , 2002, Journal of vision.

[10]  The Smith-Kettlewell USE YOUR PC TO QUICKLY MAP REMAINING VISION AFTER FOVEAL VISION LOSS , 1999 .

[11]  R. Yee,et al.  The vertical field border in hemianopia and its significance for fixation and reading. , 1998, Investigative ophthalmology & visual science.

[12]  Bernhard A. Sabel,et al.  Computer-based training for the treatment of partial blindness , 1998, Nature Medicine.

[13]  G. McConkie,et al.  The span of the effective stimulus during a fixation in reading , 1975 .

[14]  G. Moneta,et al.  Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study) , 2007 .

[15]  P. Rothwell,et al.  Transient ischaemic attack: clinical relevance, risk prediction and urgency of secondary prevention , 2009, Current opinion in neurology.

[16]  S. Trauzettel-Klosinski,et al.  Effect of visual restitution training on absolute homonymous scotomas , 2006, Neurology.

[17]  L. Arend,et al.  Reading with a macular scotoma. I. Retinal location of scotoma and fixation area. , 1986, Investigative ophthalmology & visual science.

[18]  C. Braun,et al.  Modulation of visual stimulus discrimination by sustained focal attention: an MEG study. , 2006, Investigative Ophthalmology and Visual Science.

[19]  Hedges Tr,et al.  Fresnel-Prismen - ihr Stellenwert in der Rehabilitation homonymer Hemianopsien , 1988 .

[20]  J Zihl,et al.  Restitution of visual function in patients with cerebral blindness. , 1979, Journal of neurology, neurosurgery, and psychiatry.

[21]  J. Horton,et al.  The representation of the visual field in human striate cortex. A revision of the classic Holmes map. , 1991, Archives of ophthalmology.

[22]  J. Horton,et al.  Disappointing results from Nova Vision’s visual restoration therapy , 2004, British Journal of Ophthalmology.

[23]  M. Reding,et al.  Fresnel prisms improve visual perception in stroke patients with homonymous hemianopia or unilateral visual neglect , 1990, Neurology.

[24]  V. Feigin,et al.  Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century , 2003, The Lancet Neurology.

[25]  S. Trauzettel-Klosinski,et al.  Comparing explorative saccade and flicker training in hemianopia , 2009, Neurology.

[26]  S. Trauzettel-Klosinski,et al.  Effectiveness of Magnifying Low Vision Aids in Patients with Age-Related Macular Degeneration , 2009 .

[27]  S. Trauzettel-Klosinski Eccentric fixation with hemianopic field defects: A valuable strategy to improve reading ability and an indication of cortical plasticity , 1997 .

[28]  D. Ullrich,et al.  Horizontal and vertical reading: a comparative investigation of eye movements. , 1993, German journal of ophthalmology.

[29]  G. Rubin,et al.  New standardised texts for assessing reading performance in four European languages , 2006, British Journal of Ophthalmology.

[30]  Cynthia Owsley,et al.  On-road driving performance by persons with hemianopia and quadrantanopia. , 2009, Investigative ophthalmology & visual science.

[31]  A. Rutherford,et al.  Understanding cortical visual impairment in children. , 1995, The American journal of occupational therapy : official publication of the American Occupational Therapy Association.

[32]  M. Perenin,et al.  Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect , 1998, Nature.

[33]  S. Trauzettel-Klosinski,et al.  Nasotemporal overlap of retinal ganglion cells in humans: a functional study. , 2003, Investigative ophthalmology & visual science.

[34]  Robert W Massof,et al.  Is there a standard of care for eccentric viewing training? , 2004, Journal of rehabilitation research and development.

[35]  Gordon E. Legge,et al.  Psychophysics of reading—XVI. The visual span in normal and low vision , 1997, Vision Research.

[36]  G. K. Noorden,et al.  Phenomenology of eccentric fixation. , 1962, American journal of ophthalmology.

[37]  D. Hadley,et al.  Representation of the visual field in the occipital striate cortex. , 1994, The British journal of ophthalmology.

[38]  Manfred MacKeben,et al.  Eccentric fixation in Stargardt's disease assessed by Tübingen perimetry. , 2007, Investigative ophthalmology & visual science.

[39]  Susanne Trauzettel-Klosinski,et al.  Fixation behavior and reading ability in macular scotoma: Assessed by Tuebingen manual perimetry and scanning laser ophthalmoscopy , 1996 .

[40]  Pamela S Roberts,et al.  Visual Deficit Interventions in Adult Stroke and Brain Injury: A Systematic Review , 2007, American journal of physical medicine & rehabilitation.

[41]  R. Schuchard,et al.  Preferred retinal loci relationship to macular scotomas in a low-vision population. , 1997, Ophthalmology.

[42]  J. Trobe,et al.  Isolated homonymous hemianopia. A review of 104 cases. , 1973 .

[43]  Susanne Trauzettel-Klosinski,et al.  Reading strategies in normal subjects and in patients with macular scotoma-assessedby two new methods of registration , 1994 .

[44]  H. Bedell,et al.  The oculomotor reference in humans with bilateral macular disease. , 1990, Investigative ophthalmology & visual science.

[45]  J. Rovamo,et al.  An estimation and application of the human cortical magnification factor , 2004, Experimental Brain Research.

[46]  M Mackeben,et al.  Sustained focal attention and peripheral letter recognition. , 1999, Spatial vision.

[47]  N. Pfeiffer,et al.  Erblindung in Deutschland – heute und 2030 , 2006, Der Ophthalmologe.

[48]  C. Frennesson,et al.  Patients with AMD and a large absolute central scotoma can be trained successfully to use eccentric viewing, as demonstrated in a scanning laser ophthalmoscope , 2003, Vision Research.

[49]  E. Aulhorn,et al.  Über Fixationsbreite und Fixationsfrequenz beim Lesen gerichteter Konturen , 2004, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.

[50]  S K Mannan,et al.  Saccadic visual search training: a treatment for patients with homonymous hemianopia , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[51]  G. Nelles,et al.  Compensatory visual field training for patients with hemianopia after stroke , 2001, Neuroscience Letters.

[52]  S. Trauzettel-Klosinski Reading disorders due to visual field defects: a neuro-ophthalmological view , 2002 .

[53]  G. Kerkhoff,et al.  Rehabilitation of homonymous scotomata in patients with postgeniculate damage of the visual system: saccadic compensation training. , 1992, Restorative neurology and neuroscience.

[54]  C. Mathers,et al.  Stroke incidence and prevalence in Europe: a review of available data , 2006, European journal of neurology.

[55]  E. Aulhorn Die Gesichtsfeldprüfung bei macularen Erkrankungen , 1975 .

[56]  C. Hoyt Visual function in the brain-damaged child , 2003, Eye.

[57]  Jennifer M. Zumsteg,et al.  Traumatic brain injury: a review of practice management and recent advances. , 2007, Physical medicine and rehabilitation clinics of North America.

[58]  G N Dutton,et al.  Cerebral visual impairment in children. , 2001, Seminars in neonatology : SN.

[59]  R. Näsänen,et al.  Temporal sensitivity in a hemianopic visual field can be improved by long-term training using flicker stimulation , 2006, Journal of Neurology Neurosurgery & Psychiatry.

[60]  N. Newman,et al.  Homonymous hemianopias: clinical-anatomic correlations in 904 cases. , 2006, Neurology.

[61]  A. P. Leff,et al.  Optokinetic therapy improves text reading in patients with hemianopic alexia , 2007, Neurology.

[62]  Nadia Bolognini,et al.  Visual search improvement in hemianopic patients after audio-visual stimulation , 2005 .

[63]  M. Mackeben,et al.  Parafoveal letter recognition at reduced contrast in normal aging and in patients with risk factors for AMD , 2008, Graefe's Archive for Clinical and Experimental Ophthalmology.

[64]  R. C. Sergott Community-Based Trial of a Peripheral Prism Visual Field Expansion Device for Hemianopia , 2009 .

[65]  M Mackeben,et al.  The importance of sustained attention for patients with maculopathies , 2000, Vision Research.