The impact of diabetes on coronary heart disease differs from that on ischaemic stroke with regard to the gender

BackgroundTo study the diabetes related CVD risk between men and women of different ages.MethodsHazards ratios (HRs) (95%CI) for acute CHD and ischaemic stroke events were estimated based on data of Finnish and Swedish cohorts of 5111 women and 4167 men.Results182 (3.6%) women and 348 (8.4%) men had CHD and 129 (2.5%) women and 137 (3.3%) men ischaemic stroke events. The multivariate adjusted HRs for acute CHD at age groups of 40–49, 50–59 and 60–69 years were 1.00 (1.94), 1.78 (4.23), 3.75 (8.40) in women (men) without diabetes and 4.35 (5.40), 5.49 (9.54) and 8.84 (13.76) in women (men) with diabetes. The corresponding HRs for ischaemic stroke were 1.00 (1.26), 2.48 (2.83) and 5.17 (5.11) in women (men) without diabetes and 4.14 (4.91), 3.32 (6.75) and 13.91 (18.06) in women (men) with diabetes, respectively.ConclusionCHD risk was higher in men than in women but difference reduced in diabetic population. Diabetes, however, increased stroke risk more in men than in women.

[1]  B. Zinman,et al.  Impact of diabetes on coronary artery disease in women and men: a meta-analysis of prospective studies. , 2000, Diabetes care.

[2]  M. Laakso,et al.  Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention , 2001, Journal of internal medicine.

[3]  B. Howard,et al.  Coronary heart disease risk equivalence in diabetes depends on concomitant risk factors. , 2006, Diabetes care.

[4]  F. Andreotti,et al.  Women and coronary disease , 2007, Heart.

[5]  M. Laakso,et al.  Predictors of stroke in middle-aged patients with non-insulin-dependent diabetes. , 1996, Stroke.

[6]  K. Furie,et al.  Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2008, Circulation.

[7]  J. McNeil,et al.  Incidence of Stroke Subtypes in the North East Melbourne Stroke Incidence Study (NEMESIS): Differences between Men and Women , 2008, Neuroepidemiology.

[8]  Henrik Vestergaard,et al.  The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13,000 men and women with 20 years of follow-up. , 2004, Archives of internal medicine.

[9]  M. Gomis,et al.  Sex Differences in First-Ever Acute Stroke , 2003, Stroke.

[10]  L. Wilhelmsen,et al.  Differences between coronary disease and stroke in incidence, case fatality, and risk factors, but few differences in risk factors for fatal and non-fatal events. , 2005, European heart journal.

[11]  E. Vartiainen,et al.  Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland. , 1999, Circulation.

[12]  C. Hart,et al.  Comparison of risk factors for stroke incidence and stroke mortality in 20 years of follow-up in men and women in the Renfrew/Paisley Study in Scotland. , 2000, Stroke.

[13]  N. Jairath.  Implications of gender differences on coronary artery disease risk reduction in women. , 2001, AACN clinical issues.

[14]  P. Puddu,et al.  Coronary and cerebrovascular atherosclerosis: two aspects of the same disease or two different pathologies? , 1995, Archives of gerontology and geriatrics.

[15]  K. Furie,et al.  Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2007, Circulation.

[16]  E. Vartiainen,et al.  Diabetes mellitus as a risk factor for death from stroke. Prospective study of the middle-aged Finnish population. , 1996, Stroke.

[17]  E. Barrett-Connor,et al.  Explaining the sex difference in coronary heart disease mortality among patients with type 2 diabetes mellitus: a meta-analysis. , 2002, Archives of internal medicine.

[18]  T. Thom,et al.  American Heart Association Statistics Committee and Stroke Statistics Subcommittee : Heart disease and stroke statistical-2006 update : A report from the American Heart Association Statistics Committee and Stroke statistics subcommittee , 2006 .

[19]  D. Jacobs,et al.  Trends in the incidence of coronary heart disease and stroke and the prevalence of cardiovascular risk factors among Japanese men from 1963 to 1994. , 2002, The American journal of medicine.

[20]  S. Yusuf,et al.  Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study , 2004, The Lancet.

[21]  D. Levy,et al.  Prediction of coronary heart disease using risk factor categories. , 1998, Circulation.

[22]  T. Truelsen,et al.  Trends in Stroke and Coronary Heart Disease in the WHO MONICA Project , 2003, Stroke.

[23]  P. Elwood,et al.  Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe , 2002, Journal of epidemiology and community health.

[24]  Mark Woodward,et al.  Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies , 2005, BMJ : British Medical Journal.