Functional Genomics meets neurodegenerative disorders Part I: Transcriptomic and proteomic technology
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[1] C. Adessi,et al. Improvement of the solubilization of proteins in two‐dimensional electrophoresis with immobilized pH gradients , 2006, Electrophoresis.
[2] R. Nitsch,et al. Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice , 2006, Genes, brain, and behavior.
[3] R. Ravid,et al. Proteomic and Functional Analyses Reveal a Mitochondrial Dysfunction in P301L Tau Transgenic Mice* , 2005, Journal of Biological Chemistry.
[4] Ilana S. Hairston,et al. Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice , 2005, Cell.
[5] Jason A. Papin,et al. Reconstruction of cellular signalling networks and analysis of their properties , 2005, Nature Reviews Molecular Cell Biology.
[6] Fujian Zhang,et al. Mitochondrial Proteomic Analysis of a Cell Line Model of Familial Amyotrophic Lateral Sclerosis* , 2004, Molecular & Cellular Proteomics.
[7] K. Parker,et al. Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents*S , 2004, Molecular & Cellular Proteomics.
[8] K. Markides,et al. Cerebrospinal fluid protein patterns in neurodegenerative disease revealed by liquid chromatography‐Fourier transform ion cyclotron resonance mass spectrometry , 2004, Proteomics.
[9] P. Day,et al. Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction. , 2004, Analytical biochemistry.
[10] David Martin,et al. GOToolBox: functional analysis of gene datasets based on Gene Ontology , 2004, Genome Biology.
[11] J. Götz,et al. Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models , 2004, International Journal of Developmental Neuroscience.
[12] Eliot Marshall,et al. Getting the Noise Out of Gene Arrays , 2004, Science.
[13] E. Lander,et al. Finishing the euchromatic sequence of the human genome , 2004 .
[14] Ruedi Aebersold,et al. Analysis of α-Synuclein-associated Proteins by Quantitative Proteomics*[boxs] , 2004, Journal of Biological Chemistry.
[15] M. Mann,et al. The abc's (and xyz's) of peptide sequencing , 2004, Nature Reviews Molecular Cell Biology.
[16] R. Nitsch,et al. The impact of genetic background on neurodegeneration and behavior in seizured mice , 2004, Genes, brain, and behavior.
[17] Feng Chen,et al. Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals. , 2004, Current drug targets.
[18] J. Streffer,et al. Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy , 2004, Molecular Psychiatry.
[19] S. Lipton,et al. Molecular pathways to neurodegeneration , 2004, Nature Medicine.
[20] L. Bruijn,et al. Unraveling the mechanisms involved in motor neuron degeneration in ALS. , 2004, Annual review of neuroscience.
[21] Jochen Klucken,et al. Hsp70 Reduces α-Synuclein Aggregation and Toxicity* , 2004, Journal of Biological Chemistry.
[22] Joanna M. Sasin,et al. Protein Tyrosine Phosphatases in the Human Genome , 2004, Cell.
[23] D. Goodlett,et al. Proteomic approach to studying parkinson’s disease , 2004, Molecular Neurobiology.
[24] John Q. Trojanowski,et al. Single-Cell Gene Expression Analysis: Implications for Neurodegenerative and Neuropsychiatric Disorders , 2004, Neurochemical Research.
[25] D. Lewis,et al. Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction , 2004, Psychopharmacology.
[26] C. Weissmann,et al. The role of PrP in health and disease. , 2004, Current molecular medicine.
[27] E. Rogaev,et al. Role for glyoxalase I in Alzheimer's disease. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[28] D. Bennett,et al. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. , 2004, Archives of neurology.
[29] Joachim Klose,et al. Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice* , 2004, Journal of Biological Chemistry.
[30] J Günter Grossmann,et al. Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[31] R. Nitsch,et al. Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice , 2004, Neurobiology of Disease.
[32] Allan I. Levey,et al. Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic Parkinson's and Alzheimer's Diseases* , 2004, Journal of Biological Chemistry.
[33] Marquis P Vawter,et al. Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree , 2004, Schizophrenia Research.
[34] G. Stephanopoulos,et al. Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter. , 2004, Physiological genomics.
[35] Gregory A Petsko,et al. Live and let diet , 2003, Genome Biology.
[36] D. Borchelt,et al. Environmental Enrichment Exacerbates Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease , 2003, Journal of neuropathology and experimental neurology.
[37] Bryan L Roth,et al. Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons* , 2003, Journal of Biological Chemistry.
[38] R. Nitsch,et al. β-Amyloid Induces Paired Helical Filament-like Tau Filaments in Tissue Culture* , 2003, Journal of Biological Chemistry.
[39] R. Lempicki,et al. Evaluation of gene expression measurements from commercial microarray platforms. , 2003, Nucleic acids research.
[40] Á. Pascual,et al. Induction of tyrosine kinase receptor b by retinoic acid allows brain-derived neurotrophic factor-induced amyloid precursor protein gene expression in human sh-sy5y neuroblastoma cells , 2003, Neuroscience.
[41] Douglas A. Hosack,et al. Identifying biological themes within lists of genes with EASE , 2003, Genome Biology.
[42] A. Delacourte,et al. Mitotic-like Tau Phosphorylation by p25-Cdk5 Kinase Complex* , 2003, Journal of Biological Chemistry.
[43] C. Messier. Diabetes, Alzheimer's disease and apolipoprotein genotype , 2003, Experimental Gerontology.
[44] D. Butterfield,et al. Proteomics in Alzheimer's disease: insights into potential mechanisms of neurodegeneration , 2003, Journal of neurochemistry.
[45] H. Shibasaki,et al. Presenilin 1 mediates retinoic acid‐induced differentiation of SH‐SY5Y cells through facilitation of Wnt signaling , 2003, Journal of neuroscience research.
[46] Robert Tonge,et al. Evaluation of saturation labelling two‐dimensional difference gel electrophoresis fluorescent dyes , 2003, Proteomics.
[47] Wayne F. Patton,et al. Global quantitative phosphoprotein analysis using Multiplexed Proteomics technology , 2003, Proteomics.
[48] M. Laakso,et al. Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease , 2003, The European journal of neuroscience.
[49] J. Loring,et al. Selectively Reduced Expression of Synaptic Plasticity-Related Genes in Amyloid Precursor Protein + Presenilin-1 Transgenic Mice , 2003, The Journal of Neuroscience.
[50] Visith Thongboonkerd,et al. Proteomic identification of nitrated proteins in Alzheimer's disease brain , 2003, Journal of neurochemistry.
[51] Thomas Huber,et al. Phosphoregulators: protein kinases and protein phosphatases of mouse. , 2003, Genome research.
[52] J. Collinge,et al. Molecular and clinical classification of human prion disease. , 2003, British medical bulletin.
[53] M. Beal. Mitochondria, Oxidative Damage, and Inflammation in Parkinson's Disease , 2003, Annals of the New York Academy of Sciences.
[54] J. Inman,et al. A new strategy to amplify degraded RNA from small tissue samples for microarray studies. , 2003, Nucleic acids research.
[55] E. Bézard,et al. Microarray analysis of nonhuman primates: validation of experimental models in neurological disorders , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[56] Hongqing Guo,et al. Single-Cell Microarray Analysis in Hippocampus CA1: Demonstration and Validation of Cellular Heterogeneity , 2003, The Journal of Neuroscience.
[57] H. D. Morris,et al. Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat , 2003, Neuroscience.
[58] S. Pelech,et al. Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord , 2003, Journal of neurochemistry.
[59] Y. Dudai,et al. The amygdalar circuit that acquires taste aversion memory differs from the circuit that extinguishes it , 2003, The European journal of neuroscience.
[60] A. Singleton,et al. Genes and parkinsonism , 2003, The Lancet Neurology.
[61] Subramanian Rajagopalan,et al. Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo A Novel Therapy for Parkinson's Disease , 2003, Neuron.
[62] Eden Martin,et al. Genomic convergence: identifying candidate genes for Parkinson's disease by combining serial analysis of gene expression and genetic linkage. , 2003, Human molecular genetics.
[63] F. Kamme,et al. Global gene expression analysis of single cells. , 2003, Current opinion in drug discovery & development.
[64] Zhon-Yin Zhang,et al. An overview of the protein tyrosine phosphatase superfamily. , 2003, Current topics in medicinal chemistry.
[65] F. Menzies,et al. Analysis of the Cytosolic Proteome in a Cell Culture Model of Familial Amyotrophic Lateral Sclerosis Reveals Alterations to the Proteasome, Antioxidant Defenses, and Nitric Oxide Synthetic Pathways* , 2003, The Journal of Biological Chemistry.
[66] A. Young. Huntingtin in health and disease. , 2003, The Journal of clinical investigation.
[67] K. Blennow,et al. Studies of the pathophysiological mechanisms in frontotemporal dementia by proteome analysis of CSF proteins. , 2002, Brain research. Molecular brain research.
[68] T. Hunter,et al. The Protein Kinase Complement of the Human Genome , 2002, Science.
[69] D. Alkon,et al. Memory-specific temporal profiles of gene expression in the hippocampus , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[70] Patrizia Rizzu,et al. Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism , 2002, Science.
[71] G. Sobue,et al. Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords – screening by molecular indexing and subsequent cDNA microarray analysis , 2002, FEBS letters.
[72] M. Ball,et al. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down‐regulation and up‐regulation of apoptotic and pro‐inflammatory signaling , 2002, Journal of neuroscience research.
[73] E. Mufson,et al. Gene Expression Profiles of Cholinergic Nucleus Basalis Neurons in Alzheimer's Disease , 2002, Neurochemical Research.
[74] I. Alafuzoff,et al. Proteomic analysis of protein oxidation in Alzheimer's disease brain , 2002, Electrophoresis.
[75] Jürgen Götz,et al. Glial cells under physiologic and pathologic conditions. , 2002, Archives of neurology.
[76] D. Butterfield,et al. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase‐related protein 2, α‐enolase and heat shock cognate 71 , 2002, Journal of neurochemistry.
[77] M. Strong. Biochemical markers: Summary , 2002, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.
[78] S. Shimohama,et al. Proteomic Profiling and Neurodegeneration in Alzheimer's Disease , 2002, Neurochemical Research.
[79] D. Butterfield,et al. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. , 2002, Free radical biology & medicine.
[80] A. Delacourte,et al. Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer’s disease , 2002, Neurology.
[81] Ronald J Moore,et al. Global analysis of the Deinococcus radiodurans proteome by using accurate mass tags , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[82] Tony Wyss-Coray,et al. Inflammation in Neurodegenerative Disease—A Double-Edged Sword , 2002, Neuron.
[83] Dieter Stoll,et al. Protein microarray technology. , 2002, Drug discovery today.
[84] Kelvin H. Lee,et al. Studies of potential cerebrospinal fluid molecular markers for Alzheimer's disease , 2002, Electrophoresis.
[85] S. Shimohama,et al. Analysis of the Proteomic Profiling of Brain Tissue in Alzheimer's Disease , 2002, Disease markers.
[86] J. Trojanowski,et al. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. , 2002, Free radical biology & medicine.
[87] Youmin Wang,et al. Conditions to ensure competitive hybridization in two-color microarray: a theoretical and experimental analysis. , 2002, BioTechniques.
[88] Wayne F. Patton,et al. An improved formulation of SYPRO Ruby protein gel stain: Comparison with the original formulation and with a ruthenium II tris (bathophenanthroline disulfonate) formulation , 2002, Proteomics.
[89] Kaj Blennow,et al. Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients , 2002, Neuroreport.
[90] Mary F. Lopez,et al. Applied proteomics: mitochondrial proteins and effect on function. , 2002, Circulation research.
[91] John R Yates,et al. Analysis of quantitative proteomic data generated via multidimensional protein identification technology. , 2002, Analytical chemistry.
[92] T. Haystead,et al. Molecular Biologist's Guide to Proteomics , 2002, Microbiology and Molecular Biology Reviews.
[93] B. Gerrits,et al. Preparative two‐dimensional gel electrophoresis at alkaline pH using narrow range immobilized pH gradients , 2002, Proteomics.
[94] B. Violand,et al. Development of improved cell lysis, solubilization and imaging approaches for proteomic analyses , 2002, Proteomics.
[95] T. Godfrey,et al. Real‐time Quantitative Polymerase Chain Reaction: A Potential Tool for Genetic Analysis in Neuropathology , 2002, Brain pathology.
[96] I. Everall,et al. Rapid Tyrosine Phosphorylation of Neuronal Proteins Including Tau and Focal Adhesion Kinase in Response to Amyloid-β Peptide Exposure: Involvement of Src Family Protein Kinases , 2002, The Journal of Neuroscience.
[97] G. Sobue,et al. Differential expression of inflammation‐ and apoptosis‐related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis , 2002, Journal of neurochemistry.
[98] E. Lein,et al. Transcriptional profiling reveals strict boundaries between hippocampal subregions , 2001, The Journal of comparative neurology.
[99] Ruedi Aebersold,et al. Advances in Proteome Analysis by Mass Spectrometry* , 2001, The Journal of Biological Chemistry.
[100] H. Lipp,et al. Conditioned taste aversion as a learning and memory paradigm , 2001, Behavioural Brain Research.
[101] S. Grant,et al. Proteomics in Neuroscience: From Protein to Network , 2001, The Journal of Neuroscience.
[102] R. Faull,et al. Proteomic analysis of the brain in Alzheimer’s disease: Molecular phenotype of a complex disease process , 2001, Proteomics.
[103] J M Lee,et al. A gene expression profile of Alzheimer's disease. , 2001, DNA and cell biology.
[104] J. Yates,et al. An automated multidimensional protein identification technology for shotgun proteomics. , 2001, Analytical chemistry.
[105] F. Regnier,et al. Fractionation of isotopically labeled peptides in quantitative proteomics. , 2001, Analytical chemistry.
[106] M. A. Moseley,et al. Current trends in differential expression proteomics: isotopically coded tags. , 2001, Trends in biotechnology.
[107] G. Pasinetti,et al. Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia , 2001, Journal of neuroscience research.
[108] Piali Mukherjee,et al. Gene expression profiling of the tau mutant (P301L) transgenic mouse brain , 2001, Neuroscience Letters.
[109] R. Nitsch,et al. Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils , 2001, Science.
[110] J. Hardy,et al. Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP , 2001, Science.
[111] Cheng Li,et al. Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application , 2001, Genome Biology.
[112] R. Quirion,et al. DNA microarrays in neuropsychopharmacology. , 2001, Trends in pharmacological sciences.
[113] Jürgen Götz,et al. Tau and transgenic animal models , 2001, Brain Research Reviews.
[114] Roger E Bumgarner,et al. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. , 2001, Science.
[115] M. Zirlinger,et al. Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[116] J. Belleroche,et al. Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays. , 2001 .
[117] J. Trojanowski,et al. PP2A mRNA Expression Is Quantitatively Decreased in Alzheimer's Disease Hippocampus , 2001, Experimental Neurology.
[118] D. Butterfield,et al. Protein oxidation in the brain in Alzheimer's disease , 2001, Neuroscience.
[119] J. Yates,et al. Large-scale analysis of the yeast proteome by multidimensional protein identification technology , 2001, Nature Biotechnology.
[120] Matthew Davison,et al. Validation and development of fluorescence two‐dimensional differential gel electrophoresis proteomics technology , 2001, Proteomics.
[121] A. Stensballe,et al. Characterization of phosphoproteins from electrophoretic gels by nanoscale Fe(III) affinity chromatography with off‐line mass spectrometry analysis , 2001, Proteomics.
[122] P. Brown,et al. Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions , 2001, Genome Biology.
[123] R. Nitsch,et al. Tau Filament Formation in Transgenic Mice Expressing P301L Tau* , 2001, The Journal of Biological Chemistry.
[124] D. Holtzman,et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. , 2000, The Journal of clinical investigation.
[125] Todd B. Sherer,et al. Chronic systemic pesticide exposure reproduces features of Parkinson's disease , 2000, Nature Neuroscience.
[126] A. Freemont,et al. Subtractive hybridization – genetic takeaways and the search for meaning , 2000, International journal of experimental pathology.
[127] Jiasen Lu,et al. Assessment of the sensitivity and specificity of oligonucleotide (50mer) microarrays. , 2000, Nucleic acids research.
[128] L. Wodicka,et al. Regional and strain-specific gene expression mapping in the adult mouse brain. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[129] S. Gygi,et al. Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[130] J. Shabanowitz,et al. Subfemtomole MS and MS/MS peptide sequence analysis using nano-HPLC micro-ESI fourier transform ion cyclotron resonance mass spectrometry. , 2000, Analytical chemistry.
[131] T. Dawson,et al. Oxidative Stress and Genetics in the Pathogenesis of Parkinson's Disease , 2000, Neurobiology of Disease.
[132] Wen-Lang Lin,et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein , 2000, Nature Genetics.
[133] A. Görg,et al. Towards higher resolution: Two‐dimensional Electrophoresis of Saccharomyces cerevisiae proteins using overlapping narrow immobilized pH gradients , 2000, Electrophoresis.
[134] J. Trojanowski,et al. Expression profile of transcripts in Alzheimer's disease tangle‐bearing CA1 neurons , 2000, Annals of neurology.
[135] M. Mann,et al. Proteomics to study genes and genomes , 2000, Nature.
[136] A. Roses. Pharmacogenetics and the practice of medicine , 2000, Nature.
[137] P. Verhaert,et al. Identification of two‐dimensionally separated human cerebrospinal fluid proteins by N‐terminal sequencing, matrix‐assisted laser desorption/ionization — mass spectrometry, nanoliquid chromatography‐electrospray ionization‐time of flight‐mass spectrometry, and tandem mass spectrometry , 2000, Electrophoresis.
[138] J R Yates,et al. Analysis of the microbial proteome. , 2000, Current opinion in microbiology.
[139] G. Kroemer,et al. Simplification of complex peptide mixtures for proteomic analysis: Reversible biotinylation of cysteinyl peptides , 2000, Electrophoresis.
[140] A. Görg,et al. The current state of two‐dimensional electrophoresis with immobilized pH gradients , 2000, Electrophoresis.
[141] S. Weinberger,et al. Recent advancements in surface‐enhanced laser desorption/ionization‐time of flight‐mass spectrometry , 2000, Electrophoresis.
[142] Wayne F. Patton,et al. Ultrasensitive fluorescence protein detection in isoelectric focusing gels using a ruthenium metal chelate stain , 2000, Electrophoresis.
[143] Wayne F. Patton,et al. Fluorescence detection of proteins in sodium dodecyl sulfate‐polyacrylamide gels using environmentally benign, nonfixative, saline solution , 2000, Electrophoresis.
[144] J. Rowley,et al. Generation of longer cDNA fragments from serial analysis of gene expression tags for gene identification. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[145] H. Braak,et al. Filamentous Tau Pathology in Nerve Cells, Astrocytes, and Oligodendrocytes of Aged Baboons , 2000, Journal of neuropathology and experimental neurology.
[146] J. F. Atkins,et al. Programmed ribosomal frameshifting: much ado about knotting! , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[147] D. N. Perkins,et al. Probability‐based protein identification by searching sequence databases using mass spectrometry data , 1999, Electrophoresis.
[148] M. Guazzelli,et al. Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits. , 1999, Journal of neuropathology and experimental neurology.
[149] W. Kamphorst,et al. Phenotypic variation in hereditary frontotemporal dementia with tau mutations , 1999, Annals of neurology.
[150] S. Gygi,et al. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags , 1999, Nature Biotechnology.
[151] P. Lansbury,et al. Amyloid diseases: abnormal protein aggregation in neurodegeneration. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[152] G. Anderson,et al. High-mass-measurement accuracy and 100% sequence coverage of enzymatically digested bovine serum albumin from an ESI-FTICR mass spectrum. , 1999, Analytical chemistry.
[153] A. Brookes. The essence of SNPs. , 1999, Gene.
[154] J. Yates,et al. Direct analysis of protein complexes using mass spectrometry , 1999, Nature Biotechnology.
[155] G. Anderson,et al. Probing proteomes using capillary isoelectric focusing-electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. , 1999, Analytical chemistry.
[156] G. Schellenberg,et al. A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L) , 1999, Brain : a journal of neurology.
[157] J. Weingarten,et al. Predominance of neuronal mRNAs in individual Alzheimer's disease senile plaques , 1999, Annals of neurology.
[158] D. Botstein,et al. Cluster analysis and display of genome-wide expression patterns. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[159] J Q Trojanowski,et al. Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. , 1998, The American journal of pathology.
[160] R. Reddel,et al. Differential display of mRNA , 1998, Molecular biotechnology.
[161] A. Schapira,et al. Mitochondrial dysfunction in neurodegenerative disorders. , 1998, Biochimica et biophysica acta.
[162] Q. Zhu,et al. Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[163] A Klug,et al. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[164] Ronald C. Petersen,et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 , 1998, Nature.
[165] G. Schellenberg,et al. Tau is a candidate gene for chromosome 17 frontotemporal dementia , 1998, Annals of neurology.
[166] J. Kong,et al. Massive Mitochondrial Degeneration in Motor Neurons Triggers the Onset of Amyotrophic Lateral Sclerosis in Mice Expressing a Mutant SOD1 , 1998, The Journal of Neuroscience.
[167] B. Chait,et al. Protein indentification using mass spectrometric information , 1998, Electrophoresis.
[168] S. Minoshima,et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism , 1998, Nature.
[169] A. Verkman,et al. Evidence for phosphorylation of serine 753 in CFTR using a novel metal‐ion affinity resin and matrix‐assisted laser desorption mass spectrometry , 1997, Protein science : a publication of the Protein Society.
[170] J. Morrison,et al. Life and death of neurons in the aging brain. , 1997, Science.
[171] J Collinge,et al. Human prion diseases and bovine spongiform encephalopathy (BSE). , 1997, Human molecular genetics.
[172] Robert L. Nussbaum,et al. Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease , 1997 .
[173] R. Anderegg,et al. Comprehensive on-line LC/LC/MS of proteins. , 1997, Analytical chemistry.
[174] K Johansson,et al. Heritability for Alzheimer's disease: the study of dementia in Swedish twins. , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.
[175] C. Olanow,et al. Oxidative stress and the pathogenesis of Parkinson's disease , 1996, Neurology.
[176] J. Slade,et al. Familial amyotrophic lateral sclerosis with a mutation in exon 4 of the Cu/Zn superoxide dismutase gene: pathological and immunocytochemical changes , 1996, Acta Neuropathologica.
[177] M. Terzano,et al. Precocious loss of physiological sleep in a case of Creutzfeldt Jakob disease: a serial polygraphic study. , 1995, Sleep.
[178] Y. Agid,et al. Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias , 1995, Nature.
[179] D. Butterfield,et al. Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation , 1995, Journal of neurochemistry.
[180] K. Kinzler,et al. Serial Analysis of Gene Expression , 1995, Science.
[181] D. Borchelt,et al. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria , 1995, Neuron.
[182] M. Wilm,et al. Error-tolerant identification of peptides in sequence databases by peptide sequence tags. , 1994, Analytical chemistry.
[183] M. Gurney,et al. Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis. , 1994, The American journal of pathology.
[184] C. Marsden,et al. Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease , 1994, Annals of neurology.
[185] M. Carson,et al. ALS, SOD and peroxynitrite , 1993, Nature.
[186] J. Haines,et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.
[187] B. Snow,et al. Rapidly progressive autosomal dominant parkinsonism and dementia with pallido‐ponto‐nigral degeneration , 1992, Annals of neurology.
[188] A. Pardee,et al. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. , 1992, Science.
[189] P. Mcgeer,et al. Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. , 1992, The American journal of pathology.
[190] W. Greenough,et al. Exercise and the Brain: Angiogenesis in the Adult Rat Cerebellum after Vigorous Physical Activity and Motor Skill Learning , 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[191] Ronald C. Beavis,et al. Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers. , 1991, Analytical chemistry.
[192] W. Greenough,et al. Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[193] L. Thal,et al. The Lewy body variant of Alzheimer's disease , 1990, Neurology.
[194] M. Mann,et al. Electrospray ionization for mass spectrometry of large biomolecules. , 1989, Science.
[195] E. Mufson,et al. Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrain , 1989, Experimental Neurology.
[196] M. Karas,et al. Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. , 1988, Analytical chemistry.
[197] K. Biemann. Contributions of mass spectrometry to peptide and protein structure. , 1988, Biomedical & environmental mass spectrometry.
[198] P. Castaigne,et al. The epidemiology of Creutzfeldt‐Jakob disease , 1987, Neurology.
[199] J. Porath,et al. Isolation of phosphoproteins by immobilized metal (Fe3+) affinity chromatography. , 1986, Analytical biochemistry.
[200] G. P. Smith,et al. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. , 1985, Science.
[201] P. Roepstorff,et al. Proposal for a common nomenclature for sequence ions in mass spectra of peptides. , 1984, Biomedical mass spectrometry.
[202] J. Coyle,et al. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. , 1982, Science.
[203] P. Davies,et al. SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE , 1976, The Lancet.
[204] J. Klose. Protein mapping by combined isoelectric focusing and electrophoresis of mouse tissues , 1975, Humangenetik.
[205] P. O’Farrell. High resolution two-dimensional electrophoresis of proteins. , 1975, The Journal of biological chemistry.
[206] F. Nicoletti,et al. Beta-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: correlation with the MAP kinase pathway. , 2004, Journal of Molecular Neuroscience.
[207] P. Jenner,et al. Oxidative stress in Parkinson's disease , 2003, Annals of neurology.
[208] P. Carmeliet,et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death , 2003, Nature Genetics.
[209] S. Pelech,et al. Kinetworks protein kinase multiblot analysis. , 2003, Methods in molecular biology.
[210] Jürgen Götz,et al. Alzheimer's and Parkinson's disease--overlapping or synergistic pathologies? , 2002, Trends in molecular medicine.
[211] K. Markides,et al. Peptide mapping of proteins in human body fluids using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. , 2002, Mass spectrometry reviews.
[212] D. Rodriguez,et al. Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease , 2001, Nature Genetics.
[213] G. Lubec,et al. Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain. , 2001, Journal of neural transmission. Supplementum.
[214] G. Pasinetti,et al. From cDNA microarrays to high-throughput proteomics. Implications in the search for preventive initiatives to slow the clinical progression of Alzheimer's disease dementia. , 2001, Restorative neurology and neuroscience.
[215] A. Ryo,et al. A modified serial analysis of gene expression that generates longer sequence tags by nonpalindromic cohesive linker ligation. , 2000, Analytical biochemistry.
[216] D. Schmid,et al. FTICR-mass spectrometry for high-resolution analysis in combinatorial chemistry. , 2000, Biotechnology and bioengineering.
[217] J. Pevsner,et al. High throughput analysis of gene expression in the human brain , 2000, Journal of Neuroscience Research.
[218] M. Graeber,et al. Role of Mitochondria in Parkinson Disease , 1999, Biological chemistry.
[219] W. Tatton,et al. Etiology and pathogenesis of Parkinson's disease. , 1999, Annual review of neuroscience.
[220] J. Seilhamer,et al. A comparison of selected mRNA and protein abundances in human liver , 1997, Electrophoresis.
[221] H. Sive,et al. Subtractive cloning: past, present, and future. , 1997, Annual review of biochemistry.
[222] W R Markesbery,et al. Oxidative stress hypothesis in Alzheimer's disease. , 1997, Free radical biology & medicine.
[223] G. Corthals,et al. Prefractionation of protein samples prior to two‐dimensional electrophoresis , 1997, Electrophoresis.
[224] Banks Jf,et al. Electrospray ionization mass spectrometry. , 1996 .
[225] G Brady,et al. Construction of cDNA libraries from single cells. , 1993, Methods in enzymology.
[226] R. Wyatt,et al. Cerebrospinal fluid protein variations in common to Alzheimer's disease and schizophrenia. , 1992, Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society.
[227] G. V. Van Hoesen,et al. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. , 1991, Cerebral cortex.