Plants of the Genus Lavandula: From Farm to Pharmacy

The Lavandula genus, belonging to the Lamiaceae, includes 39 species, with nearly 400 registered cultivars. Lavandula are worldwide plants that occur over the Mediterranean, Europe, North Africa, southwest Asia to southeast India. Lavandula plants have been used since ancient time to flavor and preserved food, to treat diseases including wound healing, sedative, antispasmodic, microbial and viral infections. Numerous researches have described the chemical composition and the primary components of lavender oils are the monoterpenoids (linalool, linalyl acetate, 1,8-cineole, β-ocimene, terpinen-4-ol, and camphor), sesquiterpenoids (β-caryophyllene and nerolidol) and other terpenoid compounds (e.g., perillyl alcohol). The high concentrations of linalyl acetate make them attractive in perfumery, flavoring, cosmetics and soap industries. Currently, data on the antimicrobial activity of lavender plants have been scientifically confirmed. Indeed, lavender essential oils possess wide spectra of biological activities such as antispasmodic, carminative, analgesic, sedative, hypotensive, antiseptic, antimicrobial, antifungal, antidiuretic and general tonic action. In addition, clinical studies support their uses as treatment of health conditions. However, further clinical studies are necessary to define the magnitude of the efficacy, mechanisms of action, optimal doses, long-term safety, and, potential side effects of lavender plants.

[1]  Handbook of Essential Oils , 2020 .

[2]  C. E. Swift,et al.  Growing lavender in Colorado , 2019 .

[3]  A. Mishra,et al.  Thymol, thyme, and other plant sources: Health and potential uses , 2018, Phytotherapy research : PTR.

[4]  B. Salehi,et al.  Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications , 2018, Phytotherapy research : PTR.

[5]  B. Salehi,et al.  Carvacrol and human health: A comprehensive review , 2018, Phytotherapy research : PTR.

[6]  E. Yeşilada,et al.  Assessment of potential bioavailability of major phenolic compounds in Lavandula stoechas L. ssp. stoechas , 2018, Industrial Crops and Products.

[7]  M. Roxo,et al.  Bioaccessibility and biological activity of Melissa officinalis, Lavandula latifolia and Origanum vulgare extracts: Influence of an in vitro gastrointestinal digestion , 2018 .

[8]  B. Salehi,et al.  Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus , 2018, International journal of molecular sciences.

[9]  Raffaele Pezzani,et al.  Phytotherapeutics in cancer invasion and metastasis , 2018, Phytotherapy research : PTR.

[10]  N. F. Correa-Netto,et al.  Inhaled Lavandula angustifolia essential oil inhibits consolidation of contextual- but not tone-fear conditioning in rats. , 2018, Journal of ethnopharmacology.

[11]  B. Özçelik,et al.  Chitosan coated liposome dispersions loaded with cacao hull waste extract: Effect of spray drying on physico-chemical stability and in vitro bioaccessibility , 2018 .

[12]  R. Cuman,et al.  Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response , 2018, Evidence-based complementary and alternative medicine : eCAM.

[13]  H. Aisa,et al.  Seven new phenolic compounds from Lavandula angustifolia , 2018 .

[14]  P. Vanloot,et al.  Essential oil composition, antioxidant and antibacterial activities of wild and cultivated Lavandula mairei Humbert , 2018 .

[15]  M. Keighobadi,et al.  Antileishmanial Activity of Lavandula angustifolia and Rosmarinus Officinalis Essential Oils and Nano-emulsions on Leishmania major (MRHO/IR/75/ER) , 2017, Iranian journal of parasitology.

[16]  L. Angelini,et al.  Agronomic and phytochemical evaluation of lavandin and lavender cultivars cultivated in the Tyrrhenian area of Tuscany (Italy) , 2017 .

[17]  B. Salehi,et al.  Plants of the Genus Zingiber as a Source of Bioactive Phytochemicals: From Tradition to Pharmacy , 2017, Molecules.

[18]  Z. Selamoğlu Biotechnological Approaches on Anticancer Activity of Flavonoids-Mini Review , 2017 .

[19]  A. Koçyiğit,et al.  In Vitro Antioxidant and Anticancer Activities of Some Local Plants from Bolu Province of Turkey , 2017 .

[20]  E. Mauer,et al.  The Efficacy of Lavender Aromatherapy in Reducing Preoperative Anxiety in Ambulatory Surgery Patients Undergoing Procedures in General Otolaryngology , 2017, Laryngoscope investigative otolaryngology.

[21]  P. Denev,et al.  The common lavender (Lavandula angustifolia Mill.) pectic polysaccharides modulate phagocytic leukocytes and intestinal Peyer's patch cells. , 2017, Carbohydrate polymers.

[22]  J. Abrini,et al.  Lavandula stoechas essential oil from Morocco as novel source of antileishmanial, antibacterial and antioxidant activities , 2017 .

[23]  B. Salehi,et al.  Bioactive chemical compounds in Eremurus persicus (Joub. & Spach) Boiss. essential oil and their health implications. , 2017, Cellular and molecular biology.

[24]  S. Hossain,et al.  Antibacterial activity of essential oil from lavender (Lavandula angustifolia) against pet turtle-borne pathogenic bacteria , 2017, Laboratory animal research.

[25]  B. Salehi,et al.  Susceptibility of herpes simplex virus type 1 to monoterpenes thymol, carvacrol, p-cymene and essential oils of Sinapis arvensis L., Lallemantia royleana Benth. and Pulicaria vulgaris Gaertn. , 2017, Cellular and molecular biology.

[26]  B. Salehi,et al.  Plants of the Melaleuca Genus as Antimicrobial Agents: From Farm to Pharmacy , 2017, Phytotherapy research : PTR.

[27]  A. Bikmoradi,et al.  Effect of inhalation aromatherapy with lavender essence on pain associated with intravenous catheter insertion in preschool children: A quasi-experimental study. , 2017, Complementary therapies in clinical practice.

[28]  David J. Beale,et al.  Chemometric Analysis of Lavender Essential Oils Using Targeted and Untargeted GC-MS Acquired Data for the Rapid Identification and Characterization of Oil Quality , 2017, Molecules.

[29]  B. Salehi,et al.  Medicinal plants used in the treatment of tuberculosis - Ethnobotanical and ethnopharmacological approaches. , 2017, Biotechnology advances.

[30]  F. Maggi,et al.  Chemical Composition and Antibacterial Activity of Iranian Lavandula × hybrida , 2017, Chemistry & biodiversity.

[31]  Funda Karbancioglu‐Guler,et al.  Cardamom, Cumin, and Dill Weed Essential Oils: Chemical Compositions, Antimicrobial Activities, and Mechanisms of Action against Campylobacter spp. , 2017, Molecules.

[32]  M. Goli,et al.  Quality Preservation of Air-Dried Sliced Button Mushroom (Agaricus bisporus) by Lavender (Lavendula angustifolia Mill.) Essential Oil , 2017 .

[33]  A. Jäger,et al.  Exploring Pharmacological Mechanisms of Lavender (Lavandula angustifolia) Essential Oil on Central Nervous System Targets , 2017, Front. Pharmacol..

[34]  C. Dias,et al.  Antibacterial potential of Urtica dioica and Lavandula angustifolia extracts against methicillin resistant Staphylococcus aureus isolated from diabetic foot ulcers , 2017 .

[35]  S. Ghasemi,et al.  Comparison of the Effects of Aromatherapy with Rose and Lavender on Physiological Parameters of Patients Undergoing Open Heart Surgery: A Clinical Trial , 2017 .

[36]  S. Moja,et al.  Synergistic antimicrobial activity of two binary combinations of marjoram, lavender, and wild thyme essential oils , 2017 .

[37]  Ceren Daşkaya-Dikmen,et al.  Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants , 2017, Nutrients.

[38]  Xin Liu,et al.  Three new arylbenzofurans from Lavandula angustifolia and their bioactivities , 2017 .

[39]  H. Shokri,et al.  Antifungal effects of Lavandula binaludensis and Cuminum cyminum essential oils against Candida albicans strains isolated from patients with recurrent vulvovaginal candidiasis. , 2017, Journal de mycologie medicale.

[40]  P. Liu,et al.  Effect of SOX2 on osteogenic differentiation of dental pulp stem cells. , 2017, Cellular and molecular biology.

[41]  A. Bandegi,et al.  Lavandula Reduces Heart Injury via Attenuating Tumor Necrosis Factor-Alpha and Oxidative Stress in A Rat Model of Infarct-Like Myocardial Injury , 2016, Cell journal.

[42]  Ran Chen,et al.  In Vitro and In Vivo Efficacy Studies of Lavender angustifolia Essential Oil and Its Active Constituents on the Proliferation of Human Prostate Cancer , 2016, Integrative cancer therapies.

[43]  B. Salehi,et al.  Chemical composition and functional properties of essential oils from Nepeta schiraziana Boiss , 2017 .

[44]  Z. Selamoğlu Polyphenolic Compounds in Human Health with Pharmacological Properties , 2017 .

[45]  H. Zeraati,et al.  Comparison of the effects of lavender and diazepam on the anxiety level of patients before orthopedic surgery , 2016 .

[46]  N. Tzortzakis,et al.  Effects of water stress on lavender and sage biomass production, essential oil composition and biocidal properties against Tetranychus urticae (Koch) , 2016 .

[47]  A. Mohammadpoorasl,et al.  Comparing the effects of aromatherapy massage and inhalation aromatherapy on anxiety and pain in burn patients: A single-blind randomized clinical trial. , 2016, Burns : journal of the International Society for Burn Injuries.

[48]  A. Viljoen,et al.  The In Vitro Antimicrobial Effects of Lavandula angustifolia Essential Oil in Combination with Conventional Antimicrobial Agents , 2016, Evidence-based complementary and alternative medicine : eCAM.

[49]  G. Nikolova,et al.  Protective effect of two essential oils isolated from Rosa damascena Mill. and Lavandula angustifolia Mill, and two classic antioxidants against L-dopa oxidative toxicity induced in healthy mice. , 2016, Regulatory toxicology and pharmacology : RTP.

[50]  A. Nasiri,et al.  Effect of aromatherapy massage with lavender essential oil on pain in patients with osteoarthritis of the knee: A randomized controlled clinical trial. , 2016, Complementary therapies in clinical practice.

[51]  E. Ammar,et al.  Antioxidant and wound healing activity of Lavandula aspic L. ointment. , 2016, Journal of tissue viability.

[52]  D. Díez,et al.  Antibacterial and antioxidant activity of Portuguese Lavandula luisieri (Rozeira) Rivas-Martinez and its relation with their chemical composition , 2016, SpringerPlus.

[53]  M. Sharifi-Rad,et al.  Antibacterial activities of essential oils from Iranian medicinal plants on extended-spectrum β-lactamase-producing Escherichia coli. , 2016, Cellular and molecular biology.

[54]  M. Sharifi-Rad,et al.  Anti-bacterial effect of essential oil from Xanthium strumarium against shiga toxin-producing Escherichia coli. , 2016, Cellular and molecular biology.

[55]  M. Mohammadi,et al.  Total phenolic and flavonoid contents and antioxidant activity of extracts from different populations of lavandin , 2016 .

[56]  T. Blanck,et al.  Both lavender fleur oil and unscented oil aromatherapy reduce preoperative anxiety in breast surgery patients: a randomized trial. , 2016, Journal of clinical anesthesia.

[57]  M. Sharifi-Rad,et al.  Plants of the genus Allium as antibacterial agents: From tradition to pharmacy. , 2016, Cellular and molecular biology.

[58]  J. Sharifi‐Rad,et al.  Potential of Ocimum basilicum L. and Salvia officinalis L. essential oils against biofilms of P. aeruginosa clinical isolates. , 2016, Cellular and molecular biology.

[59]  M. Sharifi-Rad,et al.  Anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of Rubiaceae, Fabaceae and Poaceae plants: A search for new sources of useful alternative antibacterials against MRSA infections. , 2016, Cellular and molecular biology.

[60]  M. Sharifi-Rad,et al.  A comparison between PLGA-PEG and NIPAAm-MAA nanocarriers in curcumin delivery for hTERT silencing in lung cancer cell line. , 2016, Cellular and molecular biology.

[61]  M. Sharifi-Rad,et al.  Tordylium persicum Boiss. & Hausskn extract: A possible alternative for treatment of pediatric infectious diseases. , 2016, Cellular and molecular biology.

[62]  María del Mar Contreras,et al.  Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L. , 2016, Journal of ethnopharmacology.

[63]  J. Sharifi‐Rad,et al.  Cytotoxic and Antioxidant Activities of Alstonia scholaris , Alstonia venenata and Moringa oleifera Plants From India , 2016 .

[64]  J. Kister,et al.  Identification of metabolomic markers of lavender and lavandin essential oils using mid-infrared spectroscopy , 2016 .

[65]  F. Chemat,et al.  Water as a green solvent combined with different techniques for extraction of essential oil from lavender flowers , 2016 .

[66]  E. Sendra Essential Oils in Foods: From Ancient Times to the 21st Century , 2016, Foods.

[67]  Motokuni Aoki,et al.  Wound healing potential of lavender oil by acceleration of granulation and wound contraction through induction of TGF-β in a rat model , 2016, BMC Complementary and Alternative Medicine.

[68]  Z. Kaya,et al.  Evaluating the efficacy of lavender aromatherapy on peripheral venous cannulation pain and anxiety: A prospective, randomized study. , 2016, Complementary therapies in clinical practice.

[69]  J. Paolini,et al.  Chemical Composition and Anti-MRSAActivity of Essential Oil and Ethanol Extract of Lavandula multifida L. from Algeria , 2016 .

[70]  Hua Zhang,et al.  Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects , 2016 .

[71]  M. K. Swamy,et al.  Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance , 2016, Molecules.

[72]  Giuseppe Cristiano,et al.  Compositional Analysis of Lavandula pinnata Essential Oils , 2016, Natural product communications.

[73]  M. Viuda‐Martos,et al.  Chemical Composition, Antioxidant and Antimicrobial Activity of Essential Oils from Organic Fennel, Parsley, and Lavender from Spain , 2016, Foods.

[74]  A. Meghea,et al.  The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates , 2016, Korean Journal of Chemical Engineering.

[75]  S. H. Sadraie,et al.  Assessment of the Neuroprotective Effects of Lavandula angustifolia Extract on the Contusive Model of Spinal Cord Injury in Wistar Rats , 2016, Front. Neurosci..

[76]  D. Giovannini,et al.  Lavandula angustifolia Mill. Essential Oil Exerts Antibacterial and Anti-Inflammatory Effect in Macrophage Mediated Immune Response to Staphylococcus aureus , 2016, Immunological investigations.

[77]  K. Dušek,et al.  Postharvest changes in essential oil content and quality of lavender flowers , 2016 .

[78]  M. Miguel,et al.  Comparative study of GC‐MS characterization, antioxidant activity and hyaluronidase inhibition of different species of Lavandula and Thymus essential oils , 2016 .

[79]  B. Herrero,et al.  Variability in essential oil composition of wild populations of Labiatae species collected in Spain , 2016 .

[80]  H. Sahraei,et al.  Analgesic and anti-inflammatory activities of hydro-alcoholic extract of Lavandula officinalis in mice: possible involvement of the cyclooxygenase type 1 and 2 enzymes , 2016 .

[81]  M. Duda,et al.  Changes in major bioactive compounds with antioxidant activity of Agastache foeniculum, Lavandula angustifolia, Melissa officinalis and Nepeta cataria: Effect of harvest time and plant species , 2015 .

[82]  M. Terentjeva,et al.  Application of lavender and rosemary essential oils improvement of the microbiological quality of chicken quarters , 2015 .

[83]  F. Katiraee,et al.  Phytochemical and antimicrobial properties of Lavender angustifolia and Eucalyptus camaldulensis essential oils , 2015 .

[84]  T. Tuttolomondo,et al.  Composition and Variability of the Essential Oil of the Flowers of Lavandula stoechas from Various Geographical Sources , 2015, Natural product communications.

[85]  Alejandro Carrasco,et al.  Lavandula stoechas essential oil from Spain: Aromatic profile determined by gas chromatography–mass spectrometry, antioxidant and lipoxygenase inhibitory bioactivities. , 2015 .

[86]  A. Moghadamnia,et al.  Antifungal Effect of Lavender Essential Oil (Lavandula angustifolia) and Clotrimazole on Candida albicans: An In Vitro Study , 2015, Scientifica.

[87]  M. Esen,et al.  The Effect of Lavender Oil in Patients with Renal Colic: A Prospective Controlled Study Using Objective and Subjective Outcome Measurements. , 2015, Journal of alternative and complementary medicine.

[88]  R. Ruseckaite,et al.  Oregano and lavender essential oils as antioxidant and antimicrobial additives of biogenic gelatin films , 2015 .

[89]  C. Toniolo,et al.  Evaluation of a Three-Component Plant Derived Extract asPreservative for Fresh Retail Meat , 2015 .

[90]  T. Marzouk,et al.  RETRACTED ARTICLE: Lavender-thymol as a new topical aromatherapy preparation for episiotomy: A randomized clinical trial , 2015, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.

[91]  L. Panjai,et al.  Effects of Increasing Doses of UV-B on Main Phenolic Acids Content, Antioxidant Activity and Estimated Biomass in Lavandin (Lavandula x intermedia) , 2015, Natural product communications.

[92]  Tengfei Ji,et al.  Evaluation on bioactivities of total flavonoids from Lavandula angustifolia. , 2015, Pakistan journal of pharmaceutical sciences.

[93]  Sasaki,et al.  Antibacterial Effect of Lavender (Lavandula) Flavor (Volatile) , 2015 .

[94]  J. Gostner,et al.  Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC , 2014, BMC Complementary and Alternative Medicine.

[95]  K. Smigielski,et al.  Composition, biological properties and therapeutic effects of lavender (Lavandula angustifolia L). A review , 2014 .

[96]  M. Rafieian-kopaei,et al.  Neuroprotective effect of pretreatment with Lavandula officinalis ethanolic extract on blood-brain barrier permeability in a rat stroke model. , 2014, Asian Pacific journal of tropical medicine.

[97]  M. Tanimoto,et al.  Lavender essential oil inhalation suppresses allergic airway inflammation and mucous cell hyperplasia in a murine model of asthma. , 2014, Life sciences.

[98]  K. Koike,et al.  Anxiolytic-like Effect of Inhalation of Essential Oil from Lavandula officinalis: Investigation of Changes in 5-HT Turnover and Involvement of Olfactory Stimulation , 2014, Natural product communications.

[99]  H. Akbari,et al.  Investigation of the effectiveness of Syzygium aromaticum, Lavandula angustifolia and Geranium robertianum essential oils in the treatment of acute external otitis: a comparative trial with ciprofloxacin. , 2014, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[100]  D. Lakušić,et al.  Seasonal Variations in the Composition of the Essential Oils of Lavandula angustifolia (Lamiacae) , 2014, Natural product communications.

[101]  R. Pagán,et al.  Chemical composition, antioxidant and antimicrobial properties of Mentha pulegium, Lavandula stoechas and Satureja calamintha Scheele essential oils and an evaluation of their bactericidal effect in combined processes , 2014 .

[102]  Ana M. Rosa da Costa,et al.  Antioxidant and anti-cholinesterase activities of Lavandula viridis L’Hér extracts after in vitro gastrointestinal digestion , 2014 .

[103]  S. Stea,et al.  Essential Oils for Complementary Treatment of Surgical Patients: State of the Art , 2014, Evidence-based complementary and alternative medicine : eCAM.

[104]  A. Bandegi,et al.  Effect of lavender oil (Lavandula angustifolia) on cerebral edema and its possible mechanisms in an experimental model of stroke , 2014, Brain Research.

[105]  J. Charati,et al.  The effects of lavender aromatherapy on pain following needle insertion into a fistula in hemodialysis patients. , 2014, Complementary therapies in clinical practice.

[106]  M. Rafieian-kopaei,et al.  The effect of pretreatment with different doses of Lavandula officinalis ethanolic extract on memory, learning and nociception , 2014 .

[107]  J. Bocianowski,et al.  YIELDING AND QUALITY OF LAVENDER FLOWERS (Lavandula angustifolia Mill.) FROM ORGANIC CULTIVATION , 2014 .

[108]  D. Adamović,et al.  Investigation of cultivated lavender (Lavandula officinalis L.) extraction and its extracts , 2014 .

[109]  Karen K. Davis,et al.  Effect of lavender aromatherapy on vital signs and perceived quality of sleep in the intermediate care unit: a pilot study. , 2014, American journal of critical care : an official publication, American Association of Critical-Care Nurses.

[110]  Chi-Mei Ku,et al.  Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes. , 2013, Food chemistry.

[111]  M. Grãos,et al.  A necrodane monoterpenoid from Lavandula luisieri essential oil as a cell‐permeable inhibitor of BACE‐1, the β‐secretase in Alzheimer's disease , 2013 .

[112]  V. Rodrigues,et al.  Chemical composition, antischistosomal and cytotoxic effects of the essential oil of Lavandula angustifolia grown in Southeastern Brazil , 2013 .

[113]  Jalal Jalali Sendi,et al.  Toxicity, development and physiological effect of Thymus vulgaris and Lavandula angustifolia essential oils on Xanthogaleruca luteola (Coleoptera: Chrysomelidae) , 2013 .

[114]  A. Romano,et al.  Protective effects of Lavandula viridis L’Hér extracts and rosmarinic acid against H2O2-induced oxidative damage in A172 human astrocyte cell line , 2013 .

[115]  A. Aliakbar,et al.  Effect of Lavandula angustifolia essential oil against lesser mulberry pyralid Glyphodes pyloalis Walker (Lep: Pyralidae) and identification of its major derivatives , 2013 .

[116]  V. Hajhashemi,et al.  Evaluation of the effect of aromatherapy with lavender essential oil on post-tonsillectomy pain in pediatric patients: a randomized controlled trial. , 2013, International journal of pediatric otorhinolaryngology.

[117]  F. Chemat,et al.  A comparison of essential oils obtained from lavandin via different extraction processes: Ultrasound, microwave, turbohydrodistillation, steam and hydrodistillation. , 2013, Journal of chromatography. A.

[118]  P. Tarantilis,et al.  Polyphenol composition and antioxidant and metal chelating activities of the solid residues from the essential oil industry , 2013 .

[119]  A. Romano,et al.  Accumulation of phenolic compounds in in vitro cultures and wild plants of Lavandula viridis L'Hér and their antioxidant and anti-cholinesterase potential. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[120]  K. Smigielski,et al.  Comparison of qualitative and quantitative chemical composition of hydrolate and essential oils of lavender (Lavandula angustifolia) , 2013 .

[121]  S. Kasper An orally administered lavandula oil preparation (Silexan) for anxiety disorder and related conditions: an evidence based review , 2013, International journal of psychiatry in clinical practice.

[122]  M. Roghani,et al.  Anti-epileptogenic and antioxidant effect of Lavandula officinalis aerial part extract against pentylenetetrazol-induced kindling in male mice. , 2013, Journal of ethnopharmacology.

[123]  M. Ferro,et al.  Anosmia does not impair the anxiolytic-like effect of lavender essential oil inhalation in mice. , 2013, Life sciences.

[124]  P. Roncalés,et al.  Use of Essential Oils as Natural Food Preservatives: Effect on the Growth of Salmonella Enteritidis in Liquid Whole Eggs Stored Under Abuse Refrigerated Conditions , 2013 .

[125]  H. Tsang,et al.  Neurophysiological and behavioural effects of lavender oil in rats with experimentally induced anxiety , 2013 .

[126]  U. Fuhr,et al.  Drug Cocktail Interaction Study on the Effect of the Orally Administered Lavender Oil Preparation Silexan on Cytochrome P450 Enzymes in Healthy Volunteers , 2013, Drug Metabolism and Disposition.

[127]  M. Mihăşan,et al.  Neuroprotective effects of inhaled lavender oil on scopolamine-induced dementia via anti-oxidative activities in rats. , 2013, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[128]  M. J. Cocero,et al.  Antimicrobial activity of lavandin essential oil formulations against three pathogenic food-borne bacteria , 2013 .

[129]  V. Gaware,et al.  Aromatherapy: Art or science , 2013 .

[130]  A. Romano,et al.  In vitro culture of lavenders (Lavandula spp.) and the production of secondary metabolites. , 2013, Biotechnology advances.

[131]  A. Zalacain,et al.  Potential application of aromatic plant extracts to prevent cheese blowing , 2013, World journal of microbiology & biotechnology.

[132]  R. Sánchez‐Vioque,et al.  Chemical characterization of Lavandula latifolia Medik. essential oil from Spanish wild populations , 2013 .

[133]  M. Cruz,et al.  Antifungal and anti-inflammatory potential of Lavandula stoechas and Thymus herba-barona essential oils , 2013 .

[134]  G. Pop,et al.  Chemical composition and antimicrobial activity of essential oils of lavender (Lavendula angustifolia) and lavandin (Lavandula x intermedia) grown in western Romania , 2013 .

[135]  K. Pilkington,et al.  Lavender and sleep: A systematic review of the evidence , 2012 .

[136]  P. Roncalés,et al.  Antioxidant and antibacterial effects of Lavandula and Mentha essential oils in minced beef inoculated with E. coli O157:H7 and S. aureus during storage at abuse refrigeration temperature. , 2012, Meat science.

[137]  M. Cruz,et al.  Lavandula luisieri essential oil as a source of antifungal drugs. , 2012, Food chemistry.

[138]  A. Romano,et al.  Supercritical fluid extraction and hydrodistillation for the recovery of bioactive compounds from Lavandula viridis L’Hér , 2012 .

[139]  N. Foster,et al.  Antioxidant activity, yield and chemical composition of lavender essential oil extracted by supercritical CO2 , 2012 .

[140]  M. Boussaid,et al.  Chemical composition and antioxidant activities of essential oils and methanol extracts of three wild Lavandula L. species , 2012, Natural product research.

[141]  Xuan Yuan,et al.  Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice , 2012, Molecules.

[142]  Yang Wang,et al.  Effect of lavender essential oil on LPS-stimulated inflammation. , 2012, The American journal of Chinese medicine.

[143]  H. Nazem,et al.  Antimicrobial Activity of Alcohol and Aqueous Extract of Lavandula angustifolia Leaves and Flowers on Staphylococcus pyogenes and Staphylococcus aureus , 2012 .

[144]  A. Raina,et al.  Comparative Essential Oil Composition of Lavendula species from India , 2012 .

[145]  D. Baldwin,et al.  Clinically relevant drug interactions in anxiety disorders , 2012, Human psychopharmacology.

[146]  Mohsen Foroughipour,et al.  Lavender Essential Oil in the Treatment of Migraine Headache: A Placebo-Controlled Clinical Trial , 2012, European Neurology.

[147]  O. Cioancă,et al.  Effects of lavender oil inhalation on improving scopolamine-induced spatial memory impairment in laboratory rats. , 2012, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[148]  Altaei Dt Topical lavender oil for the treatment of recurrent aphthous ulceration. , 2012 .

[149]  H. Haghani,et al.  Episiotomy pain relief: Use of Lavender oil essence in primiparous Iranian women. , 2012, Complementary therapies in clinical practice.

[150]  D. Missiakas,et al.  Recurrent infections and immune evasion strategies of Staphylococcus aureus. , 2012, Current opinion in microbiology.

[151]  V. Rowshan,et al.  Essential Oil Content and Composition of Lavandula Angustifolia Mill. as Affected by Drying Method and Extraction Time , 2012 .

[152]  K. Msaada,et al.  Essential Oil Composition of Lavandula dentata, L. stoechas and L. multifida Cultivated in Tunisia , 2012 .

[153]  D. T. Altaei Topical lavender oil for the treatment of recurrent aphthous ulceration. , 2012, American journal of dentistry.

[154]  J. Saxena,et al.  FLAVONOIDS AND PHENOLIC ACIDS AS ANTIOXIDANTS IN PLANTS AND HUMAN HEALTH Review Article , 2012 .

[155]  M. Tsuro,et al.  Changes in morphological phenotypes and essential oil components in lavandin (Lavandula × intermedia Emeric ex Loisel.) transformed with wild-type strains of Agrobacterium rhizogenes , 2011 .

[156]  Myeong Soo Lee,et al.  Self-aromatherapy massage of the abdomen for the reduction of menstrual pain and anxiety during menstruation in nurses: A placebo-controlled clinical trial , 2011 .

[157]  A. Romano,et al.  Inhibitory effect of Lavandula viridis on Fe(2+)-induced lipid peroxidation, antioxidant and anti-cholinesterase properties. , 2011, Food chemistry.

[158]  J. Canhoto,et al.  Chemical composition and antifungal activity of the essential oils of Lavandula viridis L'Her. , 2011, Journal of medical microbiology.

[159]  R. Bekhradi,et al.  Healing advantages of lavender essential oil during episiotomy recovery: a clinical trial. , 2011, Complementary therapies in clinical practice.

[160]  A. Hassani,et al.  Essential oil constituents of Lavandula officinalis Chaix. from Northwest Iran , 2011 .

[161]  Y. Sultanbawa Plant antimicrobials in food applications: Minireview , 2011 .

[162]  Zerihun A. Demissie,et al.  Biosynthesis and Therapeutic Properties of Lavandula Essential Oil Constituents , 2010, Planta medica.

[163]  J. Canhoto,et al.  Trichomes, essential oils and in vitro propagation of Lavandula pedunculata (Lamiaceae) , 2010 .

[164]  K. Allaf,et al.  Instant controlled pressure drop extraction of lavandin essential oils: fundamentals and experimental studies. , 2010, Journal of chromatography. A.

[165]  P. Tarantilis,et al.  Etherio, a new variety of Lavandula angustifolia with improved essential oil production and composition from natural selected genotypes growing in Greece , 2010 .

[166]  H. Möller,et al.  Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, double-blind, placebo controlled trial , 2010, International Clinical Psychopharmacology.

[167]  J. Tillett,et al.  The Uses of Aromatherapy in Women's Health , 2010, The Journal of perinatal & neonatal nursing.

[168]  Murray B Stein,et al.  The pharmacologic treatment of anxiety disorders: a review of progress. , 2010, The Journal of clinical psychiatry.

[169]  Milen I Georgiev,et al.  Volatile metabolic profiles of cell suspension cultures of Lavandula vera, Nicotiana tabacum and Helianthus annuus, cultivated under different regimes , 2010 .

[170]  Archana Singh,et al.  Essential oil composition of Lavandula angustifolia Mill. cultivated in the mid hills of Uttarakhand, India , 2010 .

[171]  M. Halm,et al.  The use of the essential oil lavandin to reduce preoperative anxiety in surgical patients. , 2009, Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses.

[172]  N. Gomes,et al.  Plants with neurobiological activity as potential targets for drug discovery , 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[173]  I. Bazos,et al.  Essential Oil Composition and Enantiomeric Distribution of Fenchone and Camphor of Lavandula cariensis and L. stoechas subsp. stoechas grown in Greece , 2009, Natural product communications.

[174]  B. Demirci,et al.  Chemical Composition and Antimicrobial Activity of the Essential Oils of Lavandula Stoechas L. Ssp. Stoechas Growing Wild in Turkey , 2009, Natural product communications.

[175]  K. Muthukumarappan,et al.  Application of natural antimicrobials for food preservation. , 2009, Journal of agricultural and food chemistry.

[176]  E. Caramão,et al.  Inhaled linalool-induced sedation in mice. , 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[177]  S. Roller,et al.  The antimicrobial activity of high-necrodane and other lavender oils on methicillin-sensitive and -resistant Staphylococcus aureus (MSSA and MRSA). , 2009, Journal of alternative and complementary medicine.

[178]  Ireneo Kikic,et al.  Flavour compounds of Lavandula angustifolia L. to use in food manufacturing: Comparison of three different extraction methods , 2009 .

[179]  Samim Saner,et al.  Review of Methods to Determine Antioxidant Capacities , 2009 .

[180]  K. Smigielski,et al.  Chemical Composition of the Essential Oil of Lavandula angustifolia Cultivated in Poland , 2009 .

[181]  E. Perry,et al.  Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti‐agitation properties: focus on ligand‐gated channels , 2008 .

[182]  Soheil S. Mahmoud,et al.  Composition of Essential Oil from Lavandula Angustifolia and L. Intermedia Varieties Grown in British Columbia, Canada , 2008 .

[183]  J. F. Arteaga,et al.  Cultivars of Lavandula Lanata Boiss., a Good Source of Lavandulol , 2008 .

[184]  A. Karlberg,et al.  Autoxidation of linalyl acetate, the main component of lavender oil, creates potent contact allergens , 2007, Contact dermatitis.

[185]  J. Abrini,et al.  Antibacterial and antioxidant activities of Origanum compactum essential oil , 2008 .

[186]  Paramvir Singh Ahuja,et al.  Economics of Lavender (Lavandula officinalis L.) in Himachal Pradesh , 2007, Journal of Non-Timber Forest Products.

[187]  A. Edris Therapeutic Potential of Essential Oils 1 Pharmaceutical and Therapeutic Potentials of Essential Oils and Their Individual Volatile Constituents: a Review , 2022 .

[188]  K. Korach,et al.  Prepubertal gynecomastia linked to lavender and tea tree oils. , 2007, The New England journal of medicine.

[189]  A. Dönmez,et al.  Constituents from the leaves of Crataegus davisii Browicz , 2006 .

[190]  M. Serralheiro,et al.  The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. , 2006, Journal of ethnopharmacology.

[191]  Shekhar Saxena,et al.  Epilepsy Care in the World: Results of an ILAE/IBE/WHO Global Campaign Against Epilepsy Survey , 2006, Epilepsia.

[192]  L. Craker,et al.  Medicinal and Aromatic Plants , 2006 .

[193]  L. Lizzani-Cuvelier,et al.  Necrodane monoterpenoids from Lavandula luisieri. , 2005, Phytochemistry.

[194]  D. Baldwin,et al.  Evidence-based pharmacotherapy of Generalized Anxiety Disorder. , 2005, The international journal of neuropsychopharmacology.

[195]  S. Sosa,et al.  Extracts and constituents of Lavandula multifida with topical anti-inflammatory activity. , 2005, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[196]  D. Agrawal,et al.  Allergic airway inflammation , 2005, Current allergy and asthma reports.

[197]  V. Cavrini,et al.  Chemical Composition of the Essential Oil from Different Aerial Parts of Lavender (Lavandula coronopofolia Poiert) (Lamiaceae) Grown in Jordan , 2005 .

[198]  Pamela M Geisel,et al.  Lavenders for California Gardens , 2004 .

[199]  M. Nogueras,et al.  Chemical Composition and Seasonal Variations of Spike Lavender Oil from Southern Spain , 2004 .

[200]  S. Andrews,et al.  The Genus Lavandula , 2004 .

[201]  G. Pauletti,et al.  The effect of growth regulators on shoot propagation and rooting of common lavender (Lavandula vera DC) , 1999, Plant Cell, Tissue and Organ Culture.

[202]  J. Segura,et al.  Plant regeneration from cultured leaves of Lavandula latifolia Medicus: Influence of growth regulators and illumination conditions , 1989, Plant Cell, Tissue and Organ Culture.

[203]  Ankush Gosain,et al.  Aging and Wound Healing , 2004, World Journal of Surgery.

[204]  A. Ghannadi,et al.  Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. , 2003, Journal of ethnopharmacology.

[205]  M. Lis‐Balchin Lavender : the genus Lavandula , 2003 .

[206]  M. Oktay,et al.  The effects of aqueous extract of Lavandula angustifolia flowers in glutamate-induced neurotoxicity of cerebellar granular cell culture of rat pups. , 2003, Journal of ethnopharmacology.

[207]  J. Wilkinson,et al.  Biological activities of Lavender essential oil , 2002, Phytotherapy research : PTR.

[208]  C. Holmes,et al.  Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study , 2002, International journal of geriatric psychiatry.

[209]  A. Gilani,et al.  Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas L. , 2000, Journal of ethnopharmacology.

[210]  Sharon L. Merritt,et al.  Efficacy and safety of herbal stimulants and sedatives in sleep disorders. , 2000, Sleep medicine reviews.

[211]  B. Cooke,et al.  Aromatherapy: a systematic review. , 2000, The British journal of general practice : the journal of the Royal College of General Practitioners.

[212]  A. K. Kukreja,et al.  Potential of lavender oil industry in Kashmir. , 2000 .

[213]  T. Onisei,et al.  Somatic embryogenesis in Lavender tissue culture : II. Influence of medium composition and gamma irradiation on embryo development , 1999 .

[214]  P. Venskutonis,et al.  Composition of the Essential Oil of Lavender (Lavandula angustifolia Mill.) from Lithuania , 1997 .

[215]  N. Kumar,et al.  EFFECT OF GROWTH REGULATOR ON THE ROOTING ABILITY OF LAVENDER (LAVANDULA ANGUSTIFOLIA MILL.) , 1996 .

[216]  O. Gamborg,et al.  Plant Cell, Tissue and Organ Culture , 1995, Springer Lab Manual.

[217]  K. Oki,et al.  Germination characteristics of herb seeds in labiatae , 1990 .

[218]  A. R. Wallace,et al.  Effects of harvest time and postharvest drying on oil from lavandin (Lavandula × intermedia) , 1989 .

[219]  B. M. Lawrence A review of the world production of essential oils (1984) , 1985 .

[220]  P. Bedoukian Perfumery and flavor materials: 42 nd annual review , 1985 .

[221]  C. R. Metcalfe The “Shab” disease of lavender , 1931 .

[222]  T. Minh,et al.  Micropropagation of lavender ( Lavandula angustifolia ) , 2022 .