Changing Patterns of Drug and Alcohol Use in Fatally Injured Drivers in Washington State

ABSTRACT: We have previously reported on patterns of drug and alcohol use in fatally injured drivers in Washington State. Here we revisit that population to examine how drug use patterns have changed in the intervening 9 years. Blood and serum specimens from drivers who died within 4 h of a traffic accident between February 1, 2001, and January 31, 2002, were analyzed for illicit and therapeutic drugs and alcohol. Drugs when present were quantitated. Samples suitable for testing were obtained from 370 fatally injured drivers. Alcohol was detected above 0.01 g/100 mL in 41% of cases. The mean alcohol concentration for those cases was 0.17 g/100 mL (range 0.02–0.39 g/100 mL). Central nervous system (CNS) active drugs were detected in 144 (39%) cases. CNS depressants including carisoprodol, diazepam, hydrocodone, diphenhydramine, amitriptyline, and others were detected in 52 cases (14.1%), cannabinoids were detected in 47 cases (12.7%), CNS stimulants (cocaine and amphetamines) were detected in 36 cases (9.7%), and narcotic analgesics (excluding morphine which is often administered iatrogenically in trauma cases) were detected in 12 cases (3.2%). For those cases which tested positive for alcohol c. 40% had other drugs present which have the potential to cause or contribute to the driver's impairment. Our report also considers the blood drug concentrations in the context of their interpretability with respect to driving impairment. The data reveal that over the past decade, while alcohol use has declined, some drug use, notably methamphetamine, has increased significantly (from 1.89% to 4.86% of fatally injured drivers) between 1992 and 2002. Combined drug and alcohol use is a very significant pattern in this population and is probably overlooked in DUI enforcement programs.

[1]  R B Voas,et al.  The relationship of alcohol safety laws to drinking drivers in fatal crashes. , 2000, Accident; analysis and prevention.

[2]  B. Logan,et al.  Methamphetamine and driving impairment. , 1996, Journal of forensic sciences.

[3]  J V Moulden,et al.  The prevalence of drugs and alcohol in fatally injured truck drivers. , 1993, Journal of forensic sciences.

[4]  M. Huestis,et al.  Blood cannabinoids. I. Absorption of THC and formation of 11-OH-THC and THCCOOH during and after smoking marijuana. , 1992, Journal of analytical toxicology.

[5]  Joris C Verster,et al.  Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic. , 2004, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[6]  M. C. Del Río,et al.  Alcohol use among fatally injured drivers in Spain. , 1999, Forensic science international.

[7]  R. F. Shaw,et al.  Cocaine- and methamphetamine-related deaths in San Diego County (1987): homicides and accidental overdoses. , 1989, Journal of forensic sciences.

[8]  F. Gengo,et al.  The pharmacodynamics of diphenhydramine‐induced drowsiness and changes in mental performance , 1989, Clinical pharmacology and therapeutics.

[9]  H. Robbe,et al.  Marijuana, alcohol and actual driving performance , 2000, Human psychopharmacology.

[10]  N. Samyn,et al.  Concentrations and ratios of amphetamine, methamphetamine, MDA, MDMA, and MDEA enantiomers determined in plasma samples from clinical toxicology and driving under the influence of drugs cases by GC-NICI-MS. , 2003, Journal of analytical toxicology.

[11]  H. Grabe,et al.  The Influence of Polypharmacological Antidepressive Treatment on Central Nervous Information Processing of Depressed Patients: Implications for Fitness to Drive , 1998, Neuropsychobiology.

[12]  B. Logan,et al.  Cause and manner of death in fatalities involving methamphetamine. , 1998, Journal of forensic sciences.

[13]  B. Sadler,et al.  Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking. , 1989, Drug metabolism and disposition: the biological fate of chemicals.

[14]  P. Swann,et al.  The involvement of drugs in drivers of motor vehicles killed in Australian road traffic crashes. , 2004, Accident; analysis and prevention.

[15]  H Gjerde,et al.  Incidence of alcohol and drugs in fatally injured car drivers in Norway. , 1993, Accident; analysis and prevention.

[16]  G W Mercer,et al.  Alcohol, drugs, and impairment in fatal traffic accidents in British Columbia. , 1995, Accident; analysis and prevention.

[17]  F. Álvarez,et al.  Presence of illegal drugs in drivers involved in fatal road traffic accidents in Spain. , 2000, Drug and alcohol dependence.

[18]  R Hingson,et al.  Lowering state legal blood alcohol limits to 0.08%: the effect on fatal motor vehicle crashes. , 1996, American journal of public health.

[19]  B. Logan,et al.  Carisoprodol, meprobamate, and driving impairment. , 2000, Journal of forensic sciences.

[20]  J F O'Hanlon,et al.  Anxiolytics' effects on the actual driving performance of patients and healthy volunteers in a standardized test. An integration of three studies. , 1995, Neuropsychobiology.

[21]  B. Logan,et al.  Drug and alcohol use in fatally injured drivers in Washington State. , 1996, Journal of forensic sciences.

[22]  B. Logan,et al.  Lorazepam and driving impairment. , 2004, Journal of analytical toxicology.

[23]  F. Couper,et al.  Zolpidem and driving impairment. , 2001, Journal of forensic sciences.

[24]  R L Yolton,et al.  The Drug Evaluation Classification Program: using ocular and other signs to detect drug intoxication. , 1998, Journal of the American Optometric Association.

[25]  Barry K Logan,et al.  Prevalence of drug use in commercial tractor-trailer drivers. , 2002, Journal of forensic sciences.

[26]  F. Couper,et al.  3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) and driving impairment. , 2001, Journal of forensic sciences.

[27]  O. Drummer Benzodiazepines - Effects on Human Performance and Behavior. , 2002, Forensic science review.

[28]  C Dussault,et al.  The role of cocaine in fatal crashes: first results of the Québec drug study. , 2001, Annual proceedings. Association for the Advancement of Automotive Medicine.

[29]  E. Kalso,et al.  The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects. , 1992, British journal of clinical pharmacology.