sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

[1]  Eugenia G. Giannopoulou,et al.  Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH , 2015, Science.

[2]  A. Weeraratna,et al.  The Wnts of change: How Wnts regulate phenotype switching in melanoma. , 2015, Biochimica et biophysica acta.

[3]  Chang Ming Li,et al.  Involvement of superoxide and nitric oxide in BRAF(V600E) inhibitor PLX4032-induced growth inhibition of melanoma cells. , 2014, Integrative biology : quantitative biosciences from nano to macro.

[4]  K. Owzar,et al.  Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration , 2014, Genes & development.

[5]  J. Mesirov,et al.  A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors. , 2014, Cancer discovery.

[6]  N. Dhomen,et al.  Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53 , 2014, Nature.

[7]  D. Schadendorf,et al.  Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma , 2014, Nature.

[8]  J. Issa Aging and epigenetic drift: a vicious cycle. , 2014, The Journal of clinical investigation.

[9]  A. Weeraratna,et al.  Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2. , 2013, Cancer discovery.

[10]  G. Garçon,et al.  Mitochondrial oxidative stress is the achille's heel of melanoma cells resistant to Braf-mutant inhibitor , 2013, Oncotarget.

[11]  L. Ferrucci,et al.  Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy , 2013, The Journal of experimental medicine.

[12]  Kajia Cao,et al.  Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape , 2013, Genes & development.

[13]  H. Park Biological Aging and Social Characteristics: Gerontology, the Baltimore City Hospitals, and the National Institutes of Health , 2012, Journal of the history of medicine and allied sciences.

[14]  R. Moon,et al.  Wnt/β-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma , 2012, Science Signaling.

[15]  M. Herlyn,et al.  Fibroblasts contribute to melanoma tumor growth and drug resistance. , 2011, Molecular pharmaceutics.

[16]  R. Dummer,et al.  In melanoma, beta-catenin is a suppressor of invasion. , 2011, Oncogene.

[17]  K. Hoek MITF: the power and the glory , 2011, Pigment cell & melanoma research.

[18]  J. Campisi,et al.  The senescence-associated secretory phenotype: the dark side of tumor suppression. , 2010, Annual review of pathology.

[19]  R. DePinho,et al.  BRafV600E cooperates with Pten silencing to elicit metastatic melanoma , 2009, Nature Genetics.

[20]  Yan Fu,et al.  MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1. , 2009, The Journal of investigative dermatology.

[21]  R. Moon,et al.  Activated Wnt/ß-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model , 2009, Proceedings of the National Academy of Sciences.

[22]  R. Dummer,et al.  In vivo switching of human melanoma cells between proliferative and invasive states. , 2008, Cancer research.

[23]  M. Herlyn,et al.  Melanoma development and progression: a conspiracy between tumor and host. , 2002, Differentiation; research in biological diversity.

[24]  M. Herlyn,et al.  Cell-surface proteolysis, growth factor activation and intercellular communication in the progression of melanoma , 2002, Critical Reviews in Oncology/Hematology.

[25]  Stephen L. Lessnick,et al.  β-Catenin–induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor , 2002, The Journal of Cell Biology.

[26]  M. Herlyn,et al.  Dynamics of cell interactions and communications during melanoma development. , 2002, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[27]  D. Elder,et al.  Melanoma-stroma interactions: structural and functional aspects. , 2002, The Lancet. Oncology.

[28]  C. Berking,et al.  Human skin reconstruct models: a new application for studies of melanocyte and melanoma biology. , 2001, Histology and histopathology.

[29]  Issa Jp CpG-island methylation in aging and cancer. , 2000 .

[30]  J. Issa,et al.  CpG-island methylation in aging and cancer. , 2000, Current topics in microbiology and immunology.

[31]  J. Campisi The role of cellular senescence in skin aging. , 1998, The journal of investigative dermatology. Symposium proceedings.