PATTERN VEP IN TWO IMMUNOCHEMICAL SUBTYPES OF OPTIC NEURITIS

Visual functions and visual evoked potentials (VEP) were compared in 2 groups of patients with optic neuritis (ON). The subdivision was based on the occurrence of oligoclonal IgG in the cerebrospinal fluid in some patients [the ON (+) group] but not in others [the ON (‐) group]. At the onset of ON there were no other signs of neurological disease in these patients. Later the majority of those in the ON (+) group had developed multiple sclerosis but only one patient in the ON (‐) group. Recovery after the acute optic inflammation was the same in both groups with respect to visual acuity and fields, but better in the ON (‐) than in the ON (+) group with respect to colour vision and pattern VEP. A closer correlation between colour vision defects and VEP latency changes was found for the ON (+) than the ON (‐) group, suggesting demyelinating disease as a more probable cause of the optic nerve inflammation in the former than in the latter group.

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