A 2‐year follow‐up study of cigarette smoking and risk of dementia

The report focused on investigating the relationship between cigarette smoking and dementia in elderly people through prospective studies. We did a 2‐year follow‐up study of elderly people. A total of 2820 participants aged 60 years old and over from six communities of Chongqing agreed to take part. Dementia was diagnosed with MMSE (Mini‐Mental State Examination) and DSM‐III‐R (Diagnostic and Statistical Manual of Mental Disorders). Participants were classified as never smokers, past smokers, and current smokers. During follow‐up, we recorded incident cases of dementia. The association of smoking and dementia was investigated using proportional hazards regression analysis. A total of 121 incident cases of dementia were detected, of which 84 (69%) were Alzheimer's disease, 17 (14%) were vascular dementia, and 21(17%) were other dementia. Compared with never smokers, current smokers had an increased risk of Alzheimer's disease (RR = 2.72; 95% CI = 1.63–5.42) and vascular dementia (RR = 1.98; 95% CI = 1.53–3.12) adjusting for age, sex, education, blood pressure, and alcohol intake. Compared with light smokers, the adjusted risk of Alzheimer's disease was significantly increased among smokers with a medium level of exposure (RR = 2.56; 95% CI = 1.65–5.52), with an even higher risk of Alzheimer's disease in the heavy smoking group (RR = 3.03; 95% CI = 1.25–4.02). Smoking was associated with the risk of dementia. This study suggests that both smoking status and amount is associated with dementia.

[1]  W. Mack,et al.  Environmental tobacco smoke and carotid arterial stiffness. , 2003, Preventive medicine.

[2]  P. Mecocci,et al.  Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challenge , 2003, British Journal of Nutrition.

[3]  L. Tune.  Great progress in diagnosis and treatment of dementia. , 2003, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[4]  D. Foley,et al.  Mid-life smoking and late-life dementia: the Honolulu-Asia Aging Study , 2003, Neurobiology of Aging.

[5]  J. Demirovic,et al.  Prevalence of dementia in three ethnic groups: the South Florida program on aging and health. , 2003, Annals of epidemiology.

[6]  G. Frisoni,et al.  The diagnosis of Alzheimer disease before it is Alzheimer dementia. , 2003, Archives of Neurology.

[7]  E. Englund,et al.  Predictors of mortality in frontotemporal dementia: a retrospective study of the prognostic influence of pre‐diagnostic features , 2003, International journal of geriatric psychiatry.

[8]  J. Gaugler,et al.  The onset of dementia caregiving and its longitudinal implications. , 2003, Psychology and aging.

[9]  E. Nanba,et al.  The effect of cigarette smoke exposure and ascorbic acid intake on gene expression of antioxidant enzymes and other related enzymes in the livers and lungs of Shionogi rats with osteogenic disorders. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[10]  C. Tsioufis,et al.  Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers , 2003, Thrombosis and Haemostasis.

[11]  J. Pankow,et al.  Risk of atherosclerosis: interaction of smoking and glutathione S-transferase genes. , 2003, Epidemiology.

[12]  H. Bernstein,et al.  Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. , 2003, Chemico-biological interactions.

[13]  H. Sauer,et al.  Pentosidine and N ε-(carboxymethyl)-lysine in Alzheimer’s disease and vascular dementia , 2003, Neurobiology of Aging.

[14]  Huadong Zhou,et al.  Study of the relationship between cigarette smoking, alcohol drinking and cognitive impairment among elderly people in China. , 2003, Age and ageing.

[15]  I. Graham,et al.  Smoking and plasma homocysteine , 2002, European heart journal.

[16]  R. Hébert,et al.  Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. , 2002, American journal of epidemiology.

[17]  G. Leo,et al.  Nicotine and neurodegeneration in ageing. , 2002, Toxicology letters.

[18]  I. Price,et al.  Effects of Transdermal Nicotine on Learning, Memory, Verbal Fluency, Concentration, and General Health in a Healthy Sample at Risk for Dementia , 2001, International Psychogeriatrics.

[19]  A. Mann,et al.  Smoking, drinking, and incident cognitive impairment: a cohort community based study included in the Gospel Oak project , 2000, Journal of neurology, neurosurgery, and psychiatry.

[20]  L. Jason,et al.  Gender and smoking behavior in a worksite smoking cessation program. , 2000, Addictive behaviors.

[21]  Zsuzsanna Nagy,et al.  Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease , 1999, The Lancet.

[22]  A. Hofman,et al.  Rates and risk factors for dementia and Alzheimer’s disease , 1999, Neurology.

[23]  G. Schumock.  Economic considerations in the treatment and management of Alzheimer's disease. , 1998, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[24]  R Brookmeyer,et al.  Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. , 1998, American journal of public health.

[25]  J. Gardin,et al.  Health care access and seven-year change in cigarette smoking. The CARDIA Study. , 1998, American journal of preventive medicine.

[26]  A. Hofman,et al.  Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study , 1998, The Lancet.

[27]  A. Hofman,et al.  Incidence and risk of dementia. The Rotterdam Study. , 1998, American journal of epidemiology.

[28]  I. Skoog.  Status of Risk Factors for Vascular Dementia , 1998, Neuroepidemiology.

[29]  E. Levin,et al.  Nicotinic System Involvement in Alzheimer’s and Parkinson’s Diseases , 1997, Drugs & aging.

[30]  J. Riggs.  Smoking and Alzheimer's disease: protective effect or differential survival bias? , 1993, The Lancet.

[31]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[32]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[33]  H. Sauer,et al.  Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia. , 2003, Neurobiology of aging.

[34]  C. Thompson.  Pharmacists must seek recognition on primary care team , 1998 .

[35]  P. Lee,et al.  Smoking and Alzheimer's disease: a review of the epidemiological evidence. , 1994, Neuroepidemiology.

[36]  A Hofman,et al.  Interaction between genetic and environmental risk factors for Alzheimer's disease: A reanalysis of case‐control studies , 1994, Genetic epidemiology.

[37]  J. Samet.  The health benefits of smoking cessation. , 1991, The Medical clinics of North America.