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An analgetic composition which comprises, as an active ingredient, a therapeutically effective amount of a synergistic mixture of an indole-3-acetic acid derivative of the formula, wherein R is a halobenzoyl, piperonylcyl or cinnamoyl group and R1 is a 5-methoxy or 5,6-methylenedioxy group; and a narcotic or anti-narcotic analgesic selected from the group consisting of a compound of the formula, wherein R2 and R3 are each a C1 - C3 alkyl group and R4 is a 4-(4-fluorophenyl)-4-oxobutyl, cyclopropylmethyl or 3-methyl-2-butenyl group; a compound of the formula, wherein R5 is a hydrogen atom or a C1 - C3 alkyl group; a compound of the formula, and a compound of the formula, wherein R6 is a C1 - C3 alkyl group; and a pharmaceutically acceptable carrier or diluent and its preparation and a method of obtaining analgesia which comprises administering the same to a patient.