Different DMRT3 Genotypes Are Best Adapted for Harness Racing and Riding in Finnhorses.

Previous studies showed a positive effect of the DMRT3 "gait keeper" mutation on harness racing performance in Standardbreds, French-, and Nordic trotters. The mutation has also been shown to influence riding traits in multiple breeds. This study investigated the effect of the DMRT3 mutation on harness racing performance and riding traits in Finnhorses. Finnhorses used for harness racing (n = 180) and for riding (n = 59) were genotyped for the DMRT3 mutation. For the trotters the genotypes were evaluated for association with racing performance (number of starts, victories, placings, earnings, and race times). At 3-6 years of age the AA genotype was superior compared with the CA and CC genotypes. The AA horses had a significantly higher proportion of victories (P = 1.4×10(-6)) and placings (P = 4.1×10(-7)), better race times (P = 0.01), and earned more money (P = 0.009) compared with C-horses. For the Finnhorses used for riding the owners answered a questionnaire to score how well the horse performed the gaits walk, trot, and canter on a scale from 1 to 6. These scores were tested for association with the DMRT3 genotypes. Although AA horses were more successful as racehorses, the CC and CA horses appear more adapted for classical riding disciplines. The AA horses received significantly lower gait scores compared with C-horses for the majority of gaits. Except for rhythm in extended canter (P = 0.05), there were no significant differences between CA and CC horses. This study shows that there are different optimal genotypes for different disciplines and the DMRT3 mutation clearly influences gaits and performance in Finnhorses.

[1]  L. Andersson,et al.  The importance of the DMRT3 ‘Gait keeper’ mutation on riding traits and gaits in Standardbred and Icelandic horses , 2015 .

[2]  S. Brooks,et al.  DMRT3 is associated with gait type in Mangalarga Marchador horses, but does not control gait ability. , 2015, Animal genetics.

[3]  A. Ricard.  Does heterozygosity at the DMRT3 gene make French trotters better racers? , 2015, Genetics Selection Evolution.

[4]  L. Andersson,et al.  Gaitedness is associated with the DMRT3 'Gait keeper' mutation in Morgan and American Curly horses. , 2014, Animal genetics.

[5]  L. Andersson,et al.  The effect of the 'Gait keeper' mutation in the DMRT3 gene on gaiting ability in Icelandic horses. , 2014, Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie.

[6]  L. Andersson,et al.  The DMRT3 'Gait keeper' mutation affects performance of Nordic and Standardbred trotters. , 2014, Journal of animal science.

[7]  E. G. Cothran,et al.  Worldwide frequency distribution of the 'Gait keeper' mutation in the DMRT3 gene. , 2014, Animal genetics.

[8]  E. G. Cothran,et al.  Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds , 2013, PLoS genetics.

[9]  K. Kullander,et al.  Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice , 2012, Nature.

[10]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[11]  T. Kikusui,et al.  Assessment of equine temperament by a questionnaire survey to caretakers and evaluation of its reliability by simultaneous behavior test , 2003 .

[12]  J. Maccluer,et al.  Inbreeding and pedigree structure in Standardbred horses , 1983 .

[13]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[14]  C. S. Baker.  Journal of heredity adopts joint data archiving policy. , 2013, The Journal of heredity.

[15]  T. Árnason.  The importance of different traits in genetic improvement of trotters. , 1994 .