Boundary condition generating large strain on breast tumor for nonlinear elasticity estimation

We describe a robotic palpation system that determines whether a breast tumor is benign or malignant by measuring its nonlinear elasticity. Two indenters compress the breast from different directions to generate sufficient strain on the inner tumor, which simply represents clinical dynamic testing. The nonlinear elasticity of the inner tumor is estimated by correcting the reaction force data of the surrounding soft tissue. Here, we present the basic concept of our study and simulation results considering geometric conditions of the indenters using a finite element breast model. Indenters with variable width are applied to the breast at several contact positions in a simulation for comparison. Our results indicate that when the spring stiffness between the contact position of one indenter and the center of the tumor equals the spring stiffness between the contact position of the other indenter and the center of the tumor, a larger contact area (i.e., larger spring stiffness) provides larger strain acting on the inner tumor.

[1]  Masakatsu G. Fujie,et al.  Nonlinear Reaction Force Analysis for Characterization of Breast Tissues , 2011, ACCAS.

[2]  J. Bamber,et al.  Quantitative elasticity imaging: what can and cannot be inferred from strain images. , 2002, Physics in medicine and biology.

[3]  T. Krouskop,et al.  Elastic Moduli of Breast and Prostate Tissues under Compression , 1998, Ultrasonic imaging.

[4]  M. Tsukune,et al.  Evaluation and comparison of the nonlinear elastic properties of the soft tissues of the breast , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[5]  R. Howe,et al.  Breast Tissue Stiffness in Compression is Correlated to Histological Diagnosis , 1999 .

[6]  Tsuyoshi Shiina,et al.  Estimation of Nonlinear Elasticity Parameter of Tissues by Ultrasound , 2002 .

[7]  Masakatsu G. Fujie,et al.  Development and validation of a viscoelastic and nonlinear liver model for needle insertion , 2008, International Journal of Computer Assisted Radiology and Surgery.

[8]  Yi Liu,et al.  Elastography Method for Reconstruction of Nonlinear Breast Tissue Properties , 2009, Int. J. Biomed. Imaging.

[9]  Masakatsu G. Fujie,et al.  Geometry effect of preloading probe on accurate needle insertion for breast tumor treatment , 2012, 2012 IEEE International Conference on Robotics and Automation.

[10]  W. Marsden I and J , 2012 .

[11]  Jung Kim,et al.  Measurement and characterization of soft tissue behavior with surface deformation and force response under large deformations , 2010, Medical Image Anal..

[12]  Joseph J O'Hagan,et al.  Measurement of the hyperelastic properties of 44 pathological ex vivo breast tissue samples , 2009, Physics in medicine and biology.