Dynamic preictal relations in FCD type II: Potential for early seizure detection in focal epilepsy

In focal epilepsy, power imbalance between spike-related high frequency oscillations (HFOs) with 80-200 Hz and post-spike slow waves (PSS) in the spike and slow waves selectively occurs within the seizure onset zone (SOZ) before seizure onset. The aim of this study was to elucidate when this preictal power imbalance could occur in the SOZ. We analyzed intracranial EEG data from 6 patients with focal cortical dysplasia. During preictal 3-min period, which was divided into three intervals: 0-1 min, 1-2 min 2-3 min before seizure onset, we performed correlation (Spearman's coefficient) and simple linear regression analyses comparing power of spike-related HFOs and PSS. We analyzed 719 ± 57 (mean ± SD) spike and slow waves per patient, which were obtained from three seizures. In the SOZ, the positive correlation between spike-related HFO and PSS power was drastically reduced during preictal 3-min period, and the slope of regression line (ΔPSS power/ΔHFO power) decreased significantly during 0-1 min before seizure onset (p < 0.05, Steel-Dwass test). The present results indicate that the preictal dynamics of HFO and PSS power in the SOZ may have utility for early seizure detection.

[1]  Jeffery A. Hall,et al.  Interictal high‐frequency oscillations (80–500 Hz) are an indicator of seizure onset areas independent of spikes in the human epileptic brain , 2008, Epilepsia.

[2]  F. Mormann,et al.  Seizure prediction: the long and winding road. , 2007, Brain : a journal of neurology.

[3]  C. Bénar,et al.  Pitfalls of high-pass filtering for detecting epileptic oscillations: A technical note on “false” ripples , 2010, Clinical Neurophysiology.

[4]  Simeon M. Wong,et al.  Preictal surrender of post–spike slow waves to spike‐related high‐frequency oscillations (80–200 Hz) is associated with seizure initiation , 2014, Epilepsia.

[5]  Jean Gotman,et al.  Erratum: High-frequency intracerebral EEG activity (100-500 Hz) following interictal spikes (Epilepsia (2006) 47, (1465-1476)) , 2006 .

[6]  I. Osorio,et al.  Correlation dimension and integral do not predict epileptic seizures. , 2005, Chaos.

[7]  C. Cepeda,et al.  Enhanced GABAergic network and receptor function in pediatric cortical dysplasia Type IIB compared with Tuberous Sclerosis Complex , 2012, Neurobiology of Disease.

[8]  Ayako Ochi,et al.  Focal resection of fast ripples on extraoperative intracranial EEG improves seizure outcome in pediatric epilepsy , 2011, Epilepsia.

[9]  H. Lüders,et al.  Presurgical evaluation of epilepsy. , 2001, Brain : a journal of neurology.

[10]  Klaus Lehnertz,et al.  Seizure Anticipation: Do Mathematical Measures Correlate with Video‐EEG Evaluation? , 2005, Epilepsia.

[11]  Pierre LeVan,et al.  High‐Frequency Intracerebral EEG Activity (100–500 Hz) Following Interictal Spikes , 2006, Epilepsia.

[12]  C. A. Marsan,et al.  CORTICAL CELLULAR PHENOMENA IN EXPERIMENTAL EPILEPSY: INTERICTAL MANIFESTATIONS. , 1964, Experimental neurology.

[13]  J. Martinerie,et al.  Preictal state identification by synchronization changes in long-term intracranial EEG recordings , 2005, Clinical Neurophysiology.

[14]  M. Steriade,et al.  Contribution of intrinsic neuronal factors in the generation of cortically driven electrographic seizures. , 2004, Journal of neurophysiology.

[15]  F. Mormann,et al.  Epileptic seizures are preceded by a decrease in synchronization , 2003, Epilepsy Research.

[16]  F. Mormann,et al.  Nonlinear EEG analysis in epilepsy: its possible use for interictal focus localization, seizure anticipation, and prevention. , 2001, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[17]  J. Parra,et al.  Epilepsies as Dynamical Diseases of Brain Systems: Basic Models of the Transition Between Normal and Epileptic Activity , 2003, Epilepsia.

[18]  H. Blumenfeld Cellular and Network Mechanisms of Spike‐Wave Seizures , 2005, Epilepsia.

[19]  H. Lüders,et al.  The epileptogenic zone: general principles. , 2006, Epileptic disorders : international epilepsy journal with videotape.

[20]  J P Lieb,et al.  Temporo-spatial patterns of pre-ictal spike activity in human temporal lobe epilepsy. , 1983, Electroencephalography and clinical neurophysiology.

[21]  J. Engel,et al.  Intracerebral recordings: organization of the human epileptogenic region. , 1993, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[22]  A. Schulze-Bonhage,et al.  The seizure prediction characteristic: a general framework to assess and compare seizure prediction methods , 2003, Epilepsy & Behavior.

[23]  J. Drake,et al.  Neurosurgical management of intractable rolandic epilepsy in children: role of resection in eloquent cortex. Clinical article. , 2009, Journal of neurosurgery. Pediatrics.

[24]  J. Klimo Neurosurgical management of intractable rolandic epilepsy in children: role of resection in eloquent cortex , 2010 .