Phospho-proteomics reveals that RSK signaling is required for proliferation of natural killer cells stimulated with IL-2 or IL-15
暂无分享,去创建一个
[1] T. Leonard,et al. Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation , 2021, Proceedings of the National Academy of Sciences.
[2] M. Babu,et al. Bioinformatic Analysis of Temporal and Spatial Proteome Alternations During Infections , 2021, Frontiers in Genetics.
[3] Ryan Cronin,et al. The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance , 2021, Oncogene.
[4] E. Ullrich,et al. Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany , 2021, Gene Therapy.
[5] M. Acevedo-Duncan,et al. Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion , 2021, Cell adhesion & migration.
[6] T. Sauter,et al. L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness , 2020, Cell communication and signaling : CCS.
[7] Ying Yang,et al. Immunomodulatory Effects of IL-2 and IL-15; Implications for Cancer Immunotherapy , 2020, Cancers.
[8] Haojie Lu,et al. O-GlcNAcylation of MEK2 promotes the proliferation and migration of breast cancer cells. , 2020, Glycobiology.
[9] Philippe P Roux,et al. RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit , 2020, bioRxiv.
[10] K. Davis,et al. RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit , 2020, Oncotarget.
[11] M. McGargill,et al. Drak2 contributes to autoimmunity by negatively regulating IL-2 signaling and altering regulatory T cell development , 2020, Journal of Immunology.
[12] V. Sexl,et al. JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation , 2019, Front. Immunol..
[13] N. Graham,et al. Quantitative Proteomics and Metabolomics Reveal Biomarkers of Disease as Potential Immunotherapy Targets and Indicators of Therapeutic Efficacy , 2019, Theranostics.
[14] J. Taunton,et al. Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals: Implications for Atherogenesis , 2019, Circulation.
[15] E. Munari,et al. Human NK cells: surface receptors, inhibitory checkpoints, and translational applications , 2019, Cellular & Molecular Immunology.
[16] Ling Lin,et al. Role of p90RSK in Kidney and Other Diseases , 2019, International journal of molecular sciences.
[17] Jill P. Mesirov,et al. A Curated Resource for Phosphosite-specific Signature Analysis* , 2018, Molecular & Cellular Proteomics.
[18] J. Babon,et al. The molecular details of cytokine signaling via the JAK/STAT pathway , 2018, Protein science : a publication of the Protein Society.
[19] P. A. Harris,et al. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. , 2018, Cancer cell.
[20] Stacey D. Finley,et al. Enhancing network activation in natural killer cells: predictions from in silico modeling , 2018, bioRxiv.
[21] Chao Yang,et al. Natural Killer Cells: Development, Maturation, and Clinical Utilization , 2018, Front. Immunol..
[22] D. Cantrell,et al. Signaling and Function of Interleukin-2 in T Lymphocytes. , 2018, Annual review of immunology.
[23] Laura L. Elo,et al. A systematic evaluation of normalization methods in quantitative label-free proteomics , 2016, Briefings Bioinform..
[24] Depei Wu,et al. Erratum: First-in-man clinical trial of CAR NK-92 cells: safety test of CD33-CAR NK-92 cells in patients with relapsed and refractory acute myeloid leukemia. , 2018, American journal of cancer research.
[25] G. Lal,et al. The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy , 2017, Front. Immunol..
[26] Z. Tian,et al. Developmental and Functional Control of Natural Killer Cells by Cytokines , 2017, Front. Immunol..
[27] D. Wolters,et al. Angiotensin II regulates phosphorylation of actin‐associated proteins in human podocytes , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[28] M. Mohsenzadegan,et al. The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells , 2017, Cell Communication and Signaling.
[29] I. Leray,et al. Cutting Edge: Differential Fine-Tuning of IL-2– and IL-15–Dependent Functions by Targeting Their Common IL-2/15Rβ/γc Receptor , 2017, The Journal of Immunology.
[30] K. Uzawa,et al. Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer , 2017, Scientific Reports.
[31] F. Khuri,et al. RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis , 2016, Oncogene.
[32] D. Tang,et al. Polo-like Kinase 1 Regulates Vimentin Phosphorylation at Ser-56 and Contraction in Smooth Muscle* , 2016, The Journal of Biological Chemistry.
[33] P. Hawkins,et al. Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8+ T Cells , 2016, Immunity.
[34] R. Kiessling,et al. IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells. , 2016, Blood.
[35] Xin Hu,et al. The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis. , 2016, Cancer letters.
[36] Marco Y. Hein,et al. The Perseus computational platform for comprehensive analysis of (prote)omics data , 2016, Nature Methods.
[37] L. Cesaro,et al. Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies , 2016, Oncotarget.
[38] Yu-Chao Wang,et al. Temporal Phosphoproteome Dynamics Induced by an ATP Synthase Inhibitor Citreoviridin* , 2015, Molecular & Cellular Proteomics.
[39] G. Hajj,et al. Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner. , 2015, Cellular signalling.
[40] Jean Yee Hwa Yang,et al. Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data , 2015, PLoS Comput. Biol..
[41] Xin Hu,et al. Stathmin and phospho-stathmin protein signature is associated with survival outcomes of breast cancer patients , 2015, Oncotarget.
[42] Jamie B. Spangler,et al. Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps. , 2015, Immunity.
[43] B. Viollet,et al. Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate. , 2015, Cellular signalling.
[44] E. Pozo-Guisado,et al. Phospho-STIM1 is a downstream effector that mediates the signaling triggered by IGF-1 in HEK293 cells. , 2015, Cellular signalling.
[45] T. Waldmann. The Shared and Contrasting Roles of IL2 and IL15 in the Life and Death of Normal and Neoplastic Lymphocytes: Implications for Cancer Therapy , 2015, Cancer Immunology Research.
[46] G. Müller-Newen,et al. Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction , 2015, Cell Communication and Signaling.
[47] C. Bourque,et al. RSK1 activation promotes invasion in nodular melanoma , 2015, Journal of Translational Medicine.
[48] Bin Zhang,et al. PhosphoSitePlus, 2014: mutations, PTMs and recalibrations , 2014, Nucleic Acids Res..
[49] E. Pozo-Guisado,et al. STIM1 phosphorylation triggered by epidermal growth factor mediates cell migration. , 2015, Biochimica et biophysica acta.
[50] Henk W. P. van den Toorn,et al. Characterization of biases in phosphopeptide enrichment by Ti(4+)-immobilized metal affinity chromatography and TiO2 using a massive synthetic library and human cell digests. , 2014, Analytical chemistry.
[51] Fella Tamzalit,et al. IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells , 2014, Proceedings of the National Academy of Sciences.
[52] Laura A. Sullivan,et al. Molecular Pathways Molecular Pathways : Interleukin-15 Signaling in Health and in Cancer , 2014 .
[53] Seung-Hwan Lee,et al. The Critical Role of IL-15–PI3K–mTOR Pathway in Natural Killer Cell Effector Functions , 2014, Front. Immunol..
[54] D. Lauffenburger,et al. Qualitatively Different T Cell Phenotypic Responses to IL-2 versus IL-15 Are Unified by Identical Dependences on Receptor Signal Strength and Duration , 2013, The Journal of Immunology.
[55] A. Upadhyaya,et al. N-WASP Is Essential for the Negative Regulation of B Cell Receptor Signaling , 2013, PLoS biology.
[56] Patricia Tomas-Martin,et al. Phosphorylation of STIM1 at ERK1/2 target sites regulates interaction with the microtubule plus-end binding protein EB1 , 2013, Journal of Cell Science.
[57] S. Mohammed,et al. Robust phosphoproteome enrichment using monodisperse microsphere–based immobilized titanium (IV) ion affinity chromatography , 2013, Nature Protocols.
[58] S. Ikemizu,et al. IL-2 and IL-15 signaling complexes: different but the same , 2012, Nature Immunology.
[59] V. Pande,et al. Mechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15 , 2012, Nature Immunology.
[60] Wen Jiang,et al. Natural killer cell lines in tumor immunotherapy , 2012, Frontiers of Medicine.
[61] H. Ljunggren,et al. Kinome Analysis of Receptor-Induced Phosphorylation in Human Natural Killer Cells , 2012, PloS one.
[62] D. Gillespie,et al. Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency. , 2011, Biochemical and biophysical research communications.
[63] Isabelle M. Mansuy,et al. Protein Phosphatase 1 (PP1) Is a Post-Translational Regulator of the Mammalian Circadian Clock , 2011, PloS one.
[64] Ji-shuai Zhang,et al. P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. , 2011, Carcinogenesis.
[65] M. Caligiuri,et al. Innate or Adaptive Immunity? The Example of Natural Killer Cells , 2011, Science.
[66] Yong-Yeon Cho,et al. RSK2 mediates NF‐κB activity through the phosphorylation of IκBα in the TNF‐R1 pathway , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[67] J. Thèze,et al. A Programmed Switch from IL-15- to IL-2-Dependent Activation in Human NK Cells1 , 2009, The Journal of Immunology.
[68] Sandhya Rani,et al. Human Protein Reference Database—2009 update , 2008, Nucleic Acids Res..
[69] M. Inagaki,et al. Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation. , 2008, Biochemical and biophysical research communications.
[70] Hubing Shi,et al. Voltage‐dependent anion channel 1 is involved in endostatin‐induced endothelial cell apoptosis , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[71] S. Gygi,et al. Ran-Binding Protein 3 Phosphorylation Links the Ras and PI3-Kinase Pathways to Nucleocytoplasmic Transport. , 2023, Molecular cell.
[72] J. Tobias,et al. Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells. , 2008, Cancer research.
[73] Jian-xin Lin,et al. Critical role for Rsk2 in T-lymphocyte activation. , 2008, Blood.
[74] Tony Pawson,et al. NetworKIN: a resource for exploring cellular phosphorylation networks , 2007, Nucleic Acids Res..
[75] J. Dayer,et al. The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors , 2007, Arthritis research & therapy.
[76] Lokesh Kumar,et al. Mfuzz: A software package for soft clustering of microarray data , 2007, Bioinformation.
[77] M. Mann,et al. Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips , 2007, Nature Protocols.
[78] Yow-Ming C Wang,et al. c-Jun N-Terminal Kinases Mediate Reactivation of Akt and Cardiomyocyte Survival After Hypoxic Injury In Vitro and In Vivo , 2005, Circulation research.
[79] D. Lauffenburger,et al. A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis , 2005, Science.
[80] E. Milford,et al. Signaling T‐Cell Survival and Death by IL‐2 and IL‐15 , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
[81] J. O’Shea,et al. Tyrosine 813 Is a Site of JAK2 Autophosphorylation Critical for Activation of JAK2 by SH2-Bβ , 2004, Molecular and Cellular Biology.
[82] J. Blenis,et al. Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity , 2003, Molecular and Cellular Biology.
[83] David M. Rocke,et al. Approximate Variance-stabilizing Transformations for Gene-expression Microarray Data , 2003, Bioinform..
[84] L. Blanchoin,et al. Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. , 2003, Molecular cell.
[85] M. Vitale,et al. Role of CREB transcription factor in c‐fos activation in natural killer cells , 2002, European journal of immunology.
[86] Matthew B. Wilson,et al. The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells , 2002, The EMBO journal.
[87] T. Waldmann,et al. The contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for the immunotherapy of rheumatological diseases , 2002, Arthritis research.
[88] L. Rodella,et al. Interleukin 2 and interleukin 15 differentially predispose natural killer cells to apoptosis mediated by endothelial and tumour cells , 2001, British journal of haematology.
[89] C. Feighery,et al. Selective Expansion and Partial Activation of Human NK Cells and NK Receptor-Positive T Cells by IL-2 and IL-151 , 2001, The Journal of Immunology.
[90] C. Kinnon,et al. Defective expression of the interleukin-2/interleukin-15 receptor beta subunit leads to a natural killer cell-deficient form of severe combined immunodeficiency. , 2001, Blood.
[91] Pavel Kovarik,et al. Serine phosphorylation of STATs , 2000, Oncogene.
[92] A. Ma,et al. The Pleiotropic Functions of Interleukin 15 , 2000, The Journal of experimental medicine.
[93] E. Gelfand,et al. Activation of p42erk2MAPK and p90rskby IL-2 Occurs Independently of Protein Kinase C , 1996 .
[94] E. Gelfand,et al. Activation of p42erk2 MAPK and p90rsk by IL-2 occurs independently of protein kinase C. , 1996, Clinical immunology and immunopathology.
[95] M. Greenberg,et al. Interleukin 2 signaling involves the phosphorylation of Stat proteins. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[96] P. Dent,et al. Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation , 1994, Molecular and cellular biology.
[97] John Calvin Reed,et al. Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line. , 1993, Proceedings of the National Academy of Sciences of the United States of America.