Biomimetic nanostructured materials: potential regulators for osteogenesis?

Nanostructured materials are gaining new impetus owing to the advancements in material fabrication techniques and their unique properties (their nanosize, high surface area-to-volume ratio, and high porosity). Such nanostructured materials mimic the subtleties of extracellular matrix (ECM) proteins, creating artifi cial microenvironments which resemble the native niches in the body. On the other hand, the isolation of mesenchymal stem cells (MSCs) from various tissue sources has resulted in the interest to study the multiple differentiation lineages for various therapeutic treatments. In this review, our focus is tailored towards the potential of biomimetic nanostructured materials as osteoinductive scaffolds for bone regeneration to differentiate MSCs towards osteoblastic cell types without the presence of soluble factors. In addition to mimicking the nanostructure of native bone, the supplement of collagen and hydroxyapatite which mimic the main components of the ECM also brings signifi cant advantages to these materials.

[1]  L. Ren,et al.  Modified PHBV scaffolds by in situ UV polymerization: structural characteristic, mechanical properties and bone mesenchymal stem cell compatibility. , 2010, Acta biomaterialia.

[2]  H. Jung,et al.  Control of osteogenic differentiation and mineralization of human mesenchymal stem cells on composite nanofibers containing poly[lactic-co-(glycolic acid)] and hydroxyapatite. , 2010, Macromolecular bioscience.

[3]  Joseph C Wenke,et al.  The design and use of animal models for translational research in bone tissue engineering and regenerative medicine. , 2010, Tissue engineering. Part B, Reviews.

[4]  Matthias P. Lutolf,et al.  Designing materials to direct stem-cell fate , 2009, Nature.

[5]  M. Prabhakaran,et al.  Electrospun nanostructured scaffolds for bone tissue engineering. , 2009, Acta biomaterialia.

[6]  Shuvo Roy,et al.  A three-dimensional scaffold with precise micro-architecture and surface micro-textures. , 2009, Biomaterials.

[7]  Gavin Jell,et al.  Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation. , 2009, Nature materials.

[8]  Casey K Chan,et al.  The fabrication of nano-hydroxyapatite on PLGA and PLGA/collagen nanofibrous composite scaffolds and their effects in osteoblastic behavior for bone tissue engineering. , 2009, Bone.

[9]  Y. Leng,et al.  Study of hydroxyapatite osteoinductivity with an osteogenic differentiation of mesenchymal stem cells. , 2009, Journal of biomedical materials research. Part A.

[10]  Shelly R. Peyton,et al.  ECM Compliance Regulates Osteogenesis by Influencing MAPK Signaling Downstream of RhoA and ROCK , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[11]  G. Daley,et al.  Bone marrow adipocytes as negative regulators of the hematopoietic microenvironment , 2009, Nature.

[12]  Casey K. Chan,et al.  Fabrication of mineralized polymeric nanofibrous composites for bone graft materials. , 2009, Tissue engineering. Part A.

[13]  Sungho Jin,et al.  Stem cell fate dictated solely by altered nanotube dimension , 2009, Proceedings of the National Academy of Sciences.

[14]  S. Ramakrishna,et al.  Remodeling of Three-dimensional Hierarchically Organized Nanofibrous Assemblies , 2008 .

[15]  A. Rowlands,et al.  Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation. , 2008, American journal of physiology. Cell physiology.

[16]  Byung-Soo Kim,et al.  In vivo bone formation following transplantation of human adipose-derived stromal cells that are not differentiated osteogenically. , 2008, Tissue engineering. Part A.

[17]  J. Czernuszka,et al.  Development of specific collagen scaffolds to support the osteogenic and chondrogenic differentiation of human bone marrow stromal cells. , 2008, Biomaterials.

[18]  Y. Tabata,et al.  Proliferation, osteogenic differentiation, and distribution of rat bone marrow stromal cells in nonwoven fabrics by different culture methods. , 2008, Tissue engineering. Part A.

[19]  B. Heng,et al.  Comparison of osteogenesis of human embryonic stem cells within 2D and 3D culture systems , 2008, Scandinavian journal of clinical and laboratory investigation.

[20]  A. Desai,et al.  Midline cleft lip , 2007 .

[21]  K. Takagishi,et al.  Evaluation of Posterolateral Spinal Fusion Using Mesenchymal Stem Cells: Differences With or Without Osteogenic Differentiation , 2007, Spine.

[22]  T. Lim,et al.  Osteo-maturation of adipose-derived stem cells required the combined action of vitamin D3, beta-glycerophosphate, and ascorbic acid. , 2007, Biochemical and biophysical research communications.

[23]  C. Wilkinson,et al.  The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. , 2007, Nature materials.

[24]  Seeram Ramakrishna,et al.  A dynamic liquid support system for continuous electrospun yarn fabrication , 2007 .

[25]  Shelly R. Peyton,et al.  The regulation of osteogenesis by ECM rigidity in MC3T3‐E1 cells requires MAPK activation , 2007, Journal of cellular physiology.

[26]  J. Ong,et al.  Effects of trabecular calcium phosphate scaffolds on stress signaling in osteoblast precursor cells. , 2007, Biomaterials.

[27]  Patrik Schmuki,et al.  Nanosize and vitality: TiO2 nanotube diameter directs cell fate. , 2007, Nano letters.

[28]  A. Minamide,et al.  The Effects of Bone Morphogenetic Protein and Basic Fibroblast Growth Factor on Cultured Mesenchymal Stem Cells for Spine Fusion , 2007, Spine.

[29]  Clemens A van Blitterswijk,et al.  A rapid and efficient method for expansion of human mesenchymal stem cells. , 2007, Tissue engineering.

[30]  Rui L Reis,et al.  Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engineering applications: Scaffold design and its performance when seeded with goat bone marrow stromal cells. , 2006, Biomaterials.

[31]  Shiao-Wen Tsai,et al.  Growth of Mesenchymal Stem Cells on Electrospun Type I Collagen Nanofibers , 2006, Stem cells.

[32]  Dietmar W Hutmacher,et al.  Co-culture of bone marrow fibroblasts and endothelial cells on modified polycaprolactone substrates for enhanced potentials in bone tissue engineering. , 2006, Tissue engineering.

[33]  S. Sen,et al.  Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.

[34]  Casey K Chan,et al.  Biomimetic nanocomposites for bone graft applications. , 2006, Nanomedicine.

[35]  S. Ramakrishna,et al.  A review on electrospinning design and nanofibre assemblies , 2006, Nanotechnology.

[36]  David L Kaplan,et al.  Electrospun silk-BMP-2 scaffolds for bone tissue engineering. , 2006, Biomaterials.

[37]  Dhirendra S Katti,et al.  Nanofibers and their applications in tissue engineering , 2006, International journal of nanomedicine.

[38]  H. Ohgushi,et al.  Tissue engineering approach to the treatment of bone tumors: three cases of cultured bone grafts derived from patients' mesenchymal stem cells. , 2006, Artificial organs.

[39]  Jeffrey C. Wang,et al.  Demineralized bone matrix and spinal arthrodesis. , 2005, The spine journal : official journal of the North American Spine Society.

[40]  Benjamin M. Wu,et al.  In vitro response of MC3T3-E1 pre-osteoblasts within three-dimensional apatite-coated PLGA scaffolds. , 2005, Journal of biomedical materials research. Part B, Applied biomaterials.

[41]  M. Kotaki,et al.  Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers. , 2005, Biomaterials.

[42]  Chun-Chieh Huang,et al.  Mesenchymal Stem Cells in the Wharton's Jelly of the Human Umbilical Cord , 2004, Stem cells.

[43]  Xuebin B. Yang,et al.  Biomimetic collagen scaffolds for human bone cell growth and differentiation. , 2004, Tissue engineering.

[44]  Farshid Guilak,et al.  Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. , 2004, Biomaterials.

[45]  J. Gimble,et al.  Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. , 2004, Current opinion in pharmacology.

[46]  N. Jørgensen,et al.  Dexamethasone, BMP-2, and 1,25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype: validation of an in vitro model for human bone marrow-derived primary osteoblasts , 2004, Steroids.

[47]  Peter X Ma,et al.  Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment. , 2003, Journal of biomedical materials research. Part A.

[48]  F. Cui,et al.  Lumbar Spinal Fusion With a Mineralized Collagen Matrix and rhBMP-2 in a Rabbit Model , 2003, Spine.

[49]  Cato T. Laurencin,et al.  Bone-Graft Substitutes: Facts, Fictions, and Applications , 2001, The Journal of bone and joint surgery. American volume.

[50]  Yoshinori Kuboki,et al.  Type I collagen‐induced osteoblastic differentiation of bone‐marrow cells mediated by collagen‐α2β1 integrin interaction , 2000 .

[51]  C. Damsky,et al.  Collagen Integrin Receptors Regulate Early Osteoblast Differentiation Induced by BMP‐2 , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[52]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[53]  D J Mooney,et al.  Development of biocompatible synthetic extracellular matrices for tissue engineering. , 1998, Trends in biotechnology.

[54]  J. Thomson,et al.  Embryonic stem cell lines derived from human blastocysts. , 1998, Science.

[55]  A. Reddi,et al.  Role of morphogenetic proteins in skeletal tissue engineering and regeneration , 1998, Nature Biotechnology.

[56]  H N Herkowitz,et al.  Pseudarthrosis of the spine. , 1992, Clinical orthopaedics and related research.

[57]  A. Bradley,et al.  Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines , 1984, Nature.

[58]  G. Martin,et al.  Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[59]  M. Kaufman,et al.  Establishment in culture of pluripotential cells from mouse embryos , 1981, Nature.

[60]  L. Xiang,et al.  Mesenchymal stem cells: a promising candidate in regenerative medicine. , 2008, The international journal of biochemistry & cell biology.

[61]  Anja Lode,et al.  Mineralised collagen—an artificial, extracellular bone matrix—improves osteogenic differentiation of bone marrow stromal cells , 2008, Journal of materials science. Materials in medicine.

[62]  Peter X Ma,et al.  Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. , 2007, Biomaterials.

[63]  D. Deligianni,et al.  Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength. , 2001, Biomaterials.

[64]  Y. Kuboki,et al.  Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction. , 2000, Journal of cellular physiology.

[65]  J. A. Cooper,et al.  Tissue engineering: orthopedic applications. , 1999, Annual review of biomedical engineering.

[66]  M. Sefton,et al.  Tissue engineering. , 1998, Journal of cutaneous medicine and surgery.