Diversity‐Oriented Synthesis of Various Enantiopure Heterocycles by Coupling Organocatalysis with Multicomponent Reactions

Chiral, enantiopure 1,3-aminoalcohols, obtained through an organocatalytic Mannich reaction, have been used as inputs in a concise sequence involving diastereoselective Ugi reaction followed by various types of SN2 cyclization. In this way, different enantiopure heterocycles have been prepared, exploring both scaffold and decoration diversity (up to 4 diversity inputs).

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