The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
暂无分享,去创建一个
David A. Agard | Andrew K. Shiau | D. Agard | P. Loria | G. Greene | A. Shiau | D. Barstad | Lin Cheng | P. Kushner | Geoffrey L. Greene | Danielle Barstad | Peter J. Kushner | Paula M. Loria | Lin Cheng
[1] R J Fletterick,et al. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors. , 1998, Science.
[2] R. Evans,et al. Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300 , 1997, Cell.
[3] R. Read,et al. Cross-validated maximum likelihood enhances crystallographic simulated annealing refinement. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[4] B. O’Malley,et al. Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily , 1995, Science.
[5] C. Glass,et al. Nuclear receptor coactivators. , 1997, Current opinion in cell biology.
[6] K. Korach. Insights from the study of animals lacking functional estrogen receptor. , 1994, Science.
[7] C. Nolan,et al. Monoclonal antibodies to human estrogen receptor. , 1980, Proceedings of the National Academy of Sciences of the United States of America.
[8] V. Jordan. Antiestrogenic action of raloxifene and tamoxifen: today and tomorrow. , 1998, Journal of the National Cancer Institute.
[9] P. Chambon,et al. The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. , 1989, The EMBO journal.
[10] T. Willson,et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ , 1998, Nature.
[11] P. Chambon,et al. TIF2, a 160 kDa transcriptional mediator for the ligand‐dependent activation function AF‐2 of nuclear receptors. , 1996, The EMBO journal.
[12] E. Kalkhoven,et al. AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors , 1997, Molecular and cellular biology.
[13] Thorsten Heinzel,et al. A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors , 1996, Cell.
[14] Z. Otwinowski,et al. [20] Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.
[15] H. Gronemeyer,et al. The nuclear receptor ligand-binding domain: structure and function. , 1998, Current opinion in cell biology.
[16] R Langridge,et al. Conic: a fast renderer for space-filling molecules with shadows. , 1991, Journal of molecular graphics.
[17] Miguel Beato,et al. Steroid hormone receptors: Many Actors in search of a plot , 1995, Cell.
[18] K. Sharp,et al. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons , 1991, Proteins.
[19] B. Katzenellenbogen,et al. Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast. , 1993, The Journal of biological chemistry.
[20] M L Welton,et al. Receptors , 2004, American journal of surgery.
[21] K. Korach,et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. , 1994, The New England journal of medicine.
[22] J. Katzenellenbogen,et al. Molecular characterization by mass spectrometry of the human estrogen receptor ligand-binding domain expressed in Escherichia coli. , 1995, Molecular endocrinology.
[23] E. Baulieu,et al. Steroid hormone receptors. , 1975, Vitamins and hormones.
[24] M. Stallcup,et al. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities. , 1998, Molecular Endocrinology.
[25] H. Gronemeyer,et al. The coactivator TIF2 contains three nuclear receptor‐binding motifs and mediates transactivation through CBP binding‐dependent and ‐independent pathways , 1998, The EMBO journal.
[26] M. Stallcup,et al. Enhancement of Estrogen Receptor Transcriptional Activity by the Coactivator GRIP-1 Highlights the Role of Activation Function 2 in Determining Estrogen Receptor Pharmacology* , 1998, The Journal of Biological Chemistry.
[27] R M Esnouf,et al. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. , 1997, Journal of molecular graphics & modelling.
[28] W. Gradishar,et al. Clinical potential of new antiestrogens. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[29] P. Chambon,et al. Role of the two activating domains of the oestrogen receptor in the cell‐type and promoter‐context dependent agonistic activity of the anti‐oestrogen 4‐hydroxytamoxifen. , 1990, The EMBO journal.
[30] P. Meltzer,et al. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. , 1997, Science.
[31] F. S. Grebbell. Shadows. , 1987, The Ulster medical journal.
[32] Collaborative Computational,et al. The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.
[33] David M. Heery,et al. A signature motif in transcriptional co-activators mediates binding to nuclear receptors , 1997, Nature.
[34] K. Grandien,et al. Printed in U.S.A. Copyright © 1997 by The Endocrine Society Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors � and � , 2022 .
[35] M. Stallcup,et al. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[36] William Bourguet,et al. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α , 1995, Nature.
[37] F. Jeanmougin,et al. A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. , 1996, The EMBO journal.
[38] Daniel Metzger,et al. Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase , 1995, Science.
[39] P B Sigler,et al. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[40] R J Fletterick,et al. Structure and specificity of nuclear receptor-coactivator interactions. , 1998, Genes & development.
[41] Christopher K. Glass,et al. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function , 1997, Nature.
[42] J. Direnzo,et al. p300 is a component of an estrogen receptor coactivator complex. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[43] V. Jordan,et al. Importance of the alkylaminoethoxy side-chain for the estrogenic and antiestrogenic actions of tamoxifen and trioxifene in the immature rat uterus , 1982, Molecular and Cellular Endocrinology.
[44] C. D. Jones,et al. Molecular determinants of tissue selectivity in estrogen receptor modulators. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[45] B. Katzenellenbogen,et al. Antiestrogen basicity--activity relationships: a comparison of the estrogen receptor binding and antiuterotrophic potencies of several analogues of (Z)-1,2-diphenyl-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-butene (tamoxifen, Nolvadex) having altered basicity. , 1982, Journal of medicinal chemistry.
[46] J M Thornton,et al. LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. , 1995, Protein engineering.
[47] E A Merritt,et al. Raster3D Version 2.0. A program for photorealistic molecular graphics. , 1994, Acta crystallographica. Section D, Biological crystallography.
[48] Hui Li,et al. RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[49] K. Horwitz,et al. Nuclear receptor coactivators and corepressors. , 1996, Molecular endocrinology.
[50] K. Smigel. Breast Cancer Prevention Trial shows major benefit, some risk. , 1998, Japanese journal of clinical oncology.
[51] William Bourguet,et al. A canonical structure for the ligand-binding domain of nuclear receptors , 1996, Nature Structural Biology.
[52] B. O’Malley,et al. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. , 1994, Annual review of biochemistry.
[53] H. Witkowska,et al. Carboxymethylation of the human estrogen receptor ligand-binding domain-estradiol complex: HPLC/ESMS peptide mapping shows that cysteine 447 does not react with iodoacetic acid , 1996, Steroids.
[54] Zbigniew Dauter,et al. Molecular basis of agonism and antagonism in the oestrogen receptor , 1997, Nature.
[55] Jean-Paul Renaud,et al. Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid , 1995, Nature.
[56] C. Nolan,et al. Purification of T47D human progesterone receptor and immunochemical characterization with monoclonal antibodies. , 1988, Molecular endocrinology.
[57] P. Chambon,et al. Functional domains of the human estrogen receptor , 1987, Cell.
[58] G. Kleywegt,et al. Halloween ... Masks and Bones , 1994 .
[59] G. Murshudov,et al. Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.
[60] J. Lees,et al. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. , 1992, The EMBO journal.
[61] D. Grainger,et al. Tamoxifen: Teaching an old drug new tricks? , 1996, Nature Medicine.