Pityriasis lichenoides et varioliformis acuta: a disease spectrum

Pityriasis lichenoides et varioliformis acuta (PLEVA), or Mucha–Habermann disease (MHD), is a cutaneous disorder evident with crops of erythematous macules and papules, usually on the trunk and flexural areas of the extremities. Its etiology remains unknown. PLEVA is speculated to be an inflammatory reaction triggered by certain infectious agents, an inflammatory response secondary to T‐cell dyscrasia, or an immune complex‐mediated hypersensitivity. Histologic examination of a skin biopsy specimen is the standard for the identification of PLEVA, but definitive diagnosis may be difficult. Apart from the febrile ulcerative variant, which may be fatal, PLEVA tends to be self‐limited in its course. Treatment is targeted mainly at the symptomatic relief of pruritus.

[1]  R. Schwartz,et al.  Chapter 15. Cutaneous Lymphoma, Leukemia, and Related Disorders , 2008 .

[2]  R. Skinner,et al.  Rapid resolution of pityriasis lichenoides et varioliformis acuta with azithromycin. , 2008, Journal of the American Academy of Dermatology.

[3]  A. Monabati,et al.  Triggering of pityriasis lichenoides et varioliformis acuta by radiocontrast iodide , 2008, The Journal of dermatological treatment.

[4]  S. Wahie,et al.  Pityriasis lichenoides: the differences between children and adults , 2007, The British journal of dermatology.

[5]  M. Akiyama,et al.  An infantile case of pityriasis lichenoides et varioliformis acuta , 2007, The British journal of dermatology.

[6]  P. S. Nair A clinical and histopathological study of pityriasis lichenoides. , 2007, Indian Journal of Dermatology, Venereology and Leprology.

[7]  A. Paller,et al.  Pityriasis lichenoides in childhood: a retrospective review of 124 patients. , 2007, Journal of the American Academy of Dermatology.

[8]  Hs Kim,et al.  A case of febrile ulceronecrotic Mucha‐Habermann's disease successfully treated with oral cyclosporin , 2007, Journal of the European Academy of Dermatology and Venereology : JEADV.

[9]  E. Warshaw,et al.  Pityriasis lichenoides and its subtypes. , 2006, Journal of the American Academy of Dermatology.

[10]  J. Szepietowski,et al.  Erythema multiforme after terbinafine intake , 2006 .

[11]  B. Cavelier-Balloy [Pityriasis lichenoides]. , 2006, Annales de dermatologie et de venereologie.

[12]  D. Slater,et al.  The new World Health Organization–European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants , 2005, The British journal of dermatology.

[13]  R. Schwartz,et al.  Pityriasis rosea: An important papulosquamous disorder , 2005, International journal of dermatology.

[14]  P. Hoeger,et al.  Transition of pityriasis lichenoides et varioliformis acuta to febrile ulceronecrotic Mucha–Habermann disease is associated with elevated serum tumour necrosis factor‐α , 2005, The British journal of dermatology.

[15]  V. Mucha Über einen der Parakeratosis variegata (Unna) bzw. Pityriasis lichenoides chronica (Neisser-Juliusberg) nahestehenden eigentümlichen Fall , 1916, Archiv für Dermatologie und Syphilis.

[16]  F. Juliusberg Ueber die Pityriasis lichenoides chronica , 1899, Archiv für Dermatologie und Syphilis.

[17]  G. Burg,et al.  Febrile ulceronecrotic Mucha-Habermann disease with clonality: a cutaneous T-cell lymphoma entity? , 2004, Journal of the American Academy of Dermatology.

[18]  N. Esterly,et al.  Lichenoid eruptions in children. , 2004, Journal of the American Academy of Dermatology.

[19]  T. Miyamoto,et al.  Febrile ulceronecrotic Mucha–Habermann disease: a case report and a review of the literature , 2003, Journal of clinical pathology.

[20]  J. Rodríguez-Peralto,et al.  Febrile ulceronecrotic pityriasis lichenoides et varioliformis acuta with atypical cells , 2003, International journal of dermatology.

[21]  A. Kovatich,et al.  Pityriasis lichenoides: a clonal T-cell lymphoproliferative disorder. , 2002, Human pathology.

[22]  S. Lessin,et al.  The clonal nature of pityriasis lichenoides. , 2002, Archives of dermatology.

[23]  M. Eskandar Pityriasis lichenoides et varioliformis acuta in pregnancy. , 2001, Saudi Medical Journal.

[24]  R. Schwartz,et al.  Insect Bite Reactions: An Update , 2001, Dermatology.

[25]  O. Dereure,et al.  T-Cell clonality in pityriasis lichenoides et varioliformis acuta: a heteroduplex analysis of 20 cases. , 2000, Archives of dermatology.

[26]  T. Tsuji,et al.  Mucha‐Habermann Disease‐like Eruptions Due to Tegafur , 1999, The Journal of dermatology.

[27]  H. Skelton,et al.  Pityriasis lichenoides et varioliformis acuta in HIV‐1 + patients: a marker of early stage disease , 1997 .

[28]  K. Smith,et al.  Pityriasis lichenoides et varioliformis acuta in HIV-1+ patients: a marker of early stage disease. The Military Medical Consortium for the Advancement of Retroviral Research (MMCARR). , 1997, International journal of dermatology.

[29]  R. Schwartz,et al.  Mucha-Habermann disease and its febrile ulceronecrotic variant. , 1996, Cutis.

[30]  R. Schwartz,et al.  Congenital and acquired early childhood syphilis. , 1995, Cutis.

[31]  W. Lambert,et al.  Dermatitic Precursors of Mycosis Fungoides , 1988 .

[32]  H. Zackheim Cutaneous Lymphoma, Leukemia, and Related Disorders , 1988 .

[33]  J. Sklar,et al.  Clonal T-cell populations in pityriasis lichenoides et varioliformis acuta (Mucha-Habermann disease). , 1987, The American journal of pathology.

[34]  R. Willemze,et al.  Clinical and histologic differentiation between lymphomatoid papulosis and pityriasis lichenoides. , 1985, Journal of the American Academy of Dermatology.

[35]  J. C. Santos Sánchez,et al.  [Papular acrodermatitis of childhood as Gianotti-Crosti syndrome]. , 1985, Anales espanoles de pediatria.

[36]  M. Mihm,et al.  Immunopathology of pityriasis lichenoides acuta. , 1984, Journal of the American Academy of Dermatology.

[37]  A. Hollander Udo Julius Wile. , 1984, Journal of the American Academy of Dermatology.

[38]  Ro Bk,et al.  A Case of Pityriasis Lichenoides et Varioliformis Acuta. , 1983 .

[39]  J. Cassidy,et al.  Mucha-Habermann disease in children -- the association with rheumatic diseases. , 1982, The Journal of rheumatology.

[40]  M. A. Everett,et al.  The nosology of parapsoriasis. , 1981, Journal of the American Academy of Dermatology.

[41]  F. J. Szymanski Pityriasis lichenoides et varioliformis acuta: histopathological evidence that it is an entity distinct from parapsoriasis. , 1959, A.M.A. archives of dermatology.

[42]  E. Habermann VIII. Über die akut verlaufende, nekrotisierende Unterart der Pityriasis lichenoides (Pityriasis lichenoides et varioliformis acuta) , 1925 .