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[1] L. Sedger,et al. Characterization of the in vivo function of TNF‐α‐related apoptosis‐inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene‐deficient mice , 2002, European journal of immunology.
[2] S. Lowe,et al. DR5 Knockout Mice Are Compromised in Radiation-Induced Apoptosis , 2005, Molecular and Cellular Biology.
[3] Wen-sheng Sun,et al. Detection of soluble TRAIL in HBV infected patients and its clinical implications. , 2002, World journal of gastroenterology.
[4] L. Hood,et al. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. , 1997, Immunity.
[5] D. Robertson. A possible technique for isolating genic DNA for quantitative traits in plants , 1985 .
[6] L. Ricci-Vitiani,et al. Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction. , 2005, Cancer research.
[7] D. Lawrence,et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. , 1999, The Journal of clinical investigation.
[8] Y. Barrière,et al. Nucleotide diversity of the ZmPox3 maize peroxidase gene: Relationships between a MITE insertion in exon 2 and variation in forage maize digestibility , 2004, BMC Genetics.
[9] Leif Andersson,et al. Domestic-animal genomics: deciphering the genetics of complex traits , 2004, Nature Reviews Genetics.
[10] Takashi Araki,et al. Hd3a, a rice ortholog of the Arabidopsis FT gene, promotes transition to flowering downstream of Hd1 under short-day conditions. , 2002, Plant & cell physiology.
[11] P. Krammer,et al. Death receptors in chemotherapy and cancer , 2004, Oncogene.
[12] M. Yano,et al. Hd1, a Major Photoperiod Sensitivity Quantitative Trait Locus in Rice, Is Closely Related to the Arabidopsis Flowering Time Gene CONSTANS , 2000, Plant Cell.
[13] M. Morgante,et al. From plant genomics to breeding practice. , 2003, Current opinion in biotechnology.
[14] I. Jeremias,et al. TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-κB , 2003, Oncogene.
[15] R. Millikan,et al. Role of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Interferon-Induced Apoptosis in Human Bladder Cancer Cells , 2004, Cancer Research.
[16] E. Dirice,et al. Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells , 2005, BMC Cancer.
[17] D. Lawrence,et al. Molecular Determinants of Kinase Pathway Activation by Apo2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand* , 2005, Journal of Biological Chemistry.
[18] Erwin G. Van Meir,et al. Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells. , 2001, Cancer research.
[19] J. Josse,et al. Quantitative trait loci underlying gene product variation: a novel perspective for analyzing regulation of genome expression. , 1994, Genetics.
[20] J. Lünemann,et al. TNF-related apoptosis inducing ligand (TRAIL) as a potential response marker for interferon-beta treatment in multiple sclerosis , 2003, The Lancet.
[21] M. Hahne,et al. Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Induces Rheumatoid Arthritis Synovial Fibroblast Proliferation through Mitogen-activated Protein Kinases and Phosphatidylinositol 3-Kinase/Akt* , 2005, Journal of Biological Chemistry.
[22] G. Martin,et al. Deductions about the Number, Organization, and Evolution of Genes in the Tomato Genome Based on Analysis of a Large Expressed Sequence Tag Collection and Selective Genomic Sequencing Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.010478. , 2002, The Plant Cell Online.
[23] R. Stoughton,et al. Genetics of gene expression surveyed in maize, mouse and man , 2003, Nature.
[24] R. Plummer,et al. Phase I and pharmacokinetic study of HGS-ETR2, a human monoclonal antibody to TRAIL R2, in patients with advanced solid malignancies , 2005 .
[25] Z. Wang,et al. Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity , 2001, Nature Medicine.
[26] L. Broemeling,et al. Novel in vivo imaging shows up-regulation of death receptors by paclitaxel and correlates with enhanced antitumor effects of receptor agonist antibodies , 2006, Molecular Cancer Therapeutics.
[27] Y. Whang,et al. Regulation of sensitivity to TRAIL by the PTEN tumor suppressor. , 2004, Vitamins and hormones.
[28] P. Sova,et al. A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.
[29] C. Akdis,et al. Decoy receptor-2 small interfering RNA (siRNA) strategy employing three different siRNA constructs in combination defeats adenovirus-transferred tumor necrosis factor-related apoptosis-inducing ligand resistance in lung cancer cells. , 2006, Human gene therapy.
[30] J. Doebley,et al. teosinte branched1 and the origin of maize: evidence for epistasis and the evolution of dominance. , 1995, Genetics.
[31] J. Tschopp,et al. The Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptors TRAIL-R1 and TRAIL-R2 Have Distinct Cross-linking Requirements for Initiation of Apoptosis and Are Non-redundant in JNK Activation* , 2000, The Journal of Biological Chemistry.
[32] Peter Schow,et al. Tumor-cell resistance to death receptor–induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax , 2002, Nature Medicine.
[33] Guo-Liang Wang,et al. Robust-LongSAGE (RL-SAGE): A Substantially Improved LongSAGE Method for Gene Discovery and Transcriptome Analysis1[w] , 2004, Plant Physiology.
[34] P. O'dwyer,et al. 17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines. , 2005, Biochemical pharmacology.
[35] A. Crosby,et al. Epidemic and Peace, 1918 , 1977 .
[36] C A Smith,et al. Identification and characterization of a new member of the TNF family that induces apoptosis. , 1995, Immunity.
[37] R. Boissy,et al. 4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo. , 2005, The Journal of investigative dermatology.
[38] John W. Keele,et al. Positional candidate gene selection from livestock EST databases using Gene Ontology , 2003, Bioinform..
[39] Joachim Messing,et al. Pattern of diversity in the genomic region near the maize domestication gene tb1. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[40] D. Killingray,et al. The Spanish Influenza Pandemic of 1918-1919 : New Perspectives , 2003 .
[41] E. Alnemri,et al. Natural Killer (NK) Cell–mediated Cytotoxicity: Differential Use of TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells , 1998, The Journal of experimental medicine.
[42] S. Costanzo,et al. Linkage disequilibrium mapping of a Verticillium dahliae resistance quantitative trait locus in tetraploid potato (Solanum tuberosum) through a candidate gene approach , 2004, Theoretical and Applied Genetics.
[43] C. Maliszewski,et al. Monocyte-mediated Tumoricidal Activity via the Tumor Necrosis Factor–related Cytokine, TRAIL , 1999, The Journal of experimental medicine.
[44] G. Luleci,et al. Differential expression of TRAIL and its receptors in benign and malignant prostate tissues. , 2007, The Journal of urology.
[45] T. Rebbeck,et al. Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[46] Salima J Alladina,et al. TRAIL-Induced Apoptosis in Human Vascular Endothelium Is Regulated by Phosphatidylinositol 3-Kinase/Akt through the Short Form of Cellular FLIP and Bcl-2 , 2005, Journal of Vascular Research.
[47] Rithy K. Roth,et al. Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays , 2000, Nature Biotechnology.
[48] A. Eggert,et al. Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression , 2000, Oncogene.
[49] S. Korsmeyer,et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours , 2005, Nature.
[50] Won-Kyung Cho,et al. Adeno‐associated virus‐mediated gene transfer of a secreted form of TRAIL inhibits tumor growth and occurrence in an experimental tumor model , 2006, The journal of gene medicine.
[51] F. Khuri,et al. Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. , 2006, Cancer research.
[52] T. Griffith,et al. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. , 1998, Journal of immunology.
[53] P. Hersey,et al. Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma. , 1999, Cancer research.
[54] P. Valéry. Regards sur le monde actuel , 1932 .
[55] W. El-Deiry,et al. Deficient Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Death Receptor Transport to the Cell Surface in Human Colon Cancer Cells Selected for Resistance to TRAIL-induced Apoptosis* , 2004, Journal of Biological Chemistry.
[56] A. Valleron,et al. Épidémiologie et canicules : analyses de la vague de chaleur 2003 en France , 2004 .
[57] W. McCombie,et al. Sequencing the maize genome. , 2004, Current opinion in plant biology.
[58] C. Qian,et al. Synergistic induction of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying TRAIL , 2007, Molecular and Cellular Biochemistry.
[59] A. Evdokiou,et al. Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy , 2003, British Journal of Cancer.
[60] J. Doebley,et al. The evolution of apical dominance in maize , 1997, Nature.
[61] John Calvin Reed,et al. PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2 , 2003, Oncogene.
[62] S. E. F. Tran,et al. MAPK/ERK Overrides the Apoptotic Signaling from Fas, TNF, and TRAIL Receptors* , 2001, The Journal of Biological Chemistry.
[63] G. Screaton,et al. Expression of TRAIL and TRAIL receptors in normal and malignant tissues , 2005, Cell Research.
[64] J. Houghton,et al. Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines. , 2005, Cancer research.
[65] Xiaodong Wang,et al. A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death , 2004, Science.
[66] D. Seol,et al. Generation of a novel proform of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein that can be reactivated by matrix metalloproteinases. , 2006, Experimental cell research.
[67] C. Smith,et al. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. , 1997, Immunity.
[68] A. Ruggeri,et al. A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells , 2003, Leukemia.
[69] B. Coventry,et al. Apo2l/Tumor necrosis factor-related apoptosis-inducing ligand prevents breast cancer-induced bone destruction in a mouse model. , 2006, Cancer research.
[70] H. Friess,et al. Effects and expression of TRAIL and its apoptosis-promoting receptors in human pancreatic cancer. , 2001, Cancer letters.
[71] Masayuki Takahashi,et al. Role of phosphatidylinositol‐3 kinase/Akt pathway in bladder cancer cell apoptosis induced by tumor necrosis factor‐related apoptosis‐inducing ligand , 2006, Cancer science.
[72] S. Salvi,et al. Mapping QTLs regulating morpho-physiological traits and yield: case studies, shortcomings and perspectives in drought-stressed maize. , 2002, Annals of botany.
[73] T. Rocheford,et al. Dissection of Maize Kernel Composition and Starch Production by Candidate Gene Association , 2004, The Plant Cell Online.
[74] R. Dubose,et al. Cloning and Characterization of TRAIL-R3, a Novel Member of the Emerging TRAIL Receptor Family , 1997, The Journal of experimental medicine.
[75] C. Belka,et al. Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis , 2005, BMC Cancer.
[76] T. Sayers,et al. TNF‐related apoptosis‐inducing ligand as a therapeutic agent in autoimmunity and cancer , 2006, Immunology and cell biology.
[77] J. Thoday,et al. Location of Polygenes , 1961, Nature.
[78] G. Cohen,et al. Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1 , 2005, Cell Death and Differentiation.
[79] E. Buckler,et al. Structure of linkage disequilibrium in plants. , 2003, Annual review of plant biology.
[80] G. Screaton,et al. Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[81] M. Tanimoto,et al. Activated human umbilical cord blood dendritic cells kill tumor cells without damaging normal hematological progenitor cells , 2005, Cancer science.
[82] G. Charmet,et al. Colocation between a gene encoding the bZip factor SPA and an eQTL for a high-molecular-weight glutenin subunit in wheat (Triticum aestivum). , 2004, Genome.
[83] K. Sax,et al. The Association of Size Differences with Seed-Coat Pattern and Pigmentation in PHASEOLUS VULGARIS. , 1923, Genetics.
[84] A. Musani,et al. Differential Expression of TRAIL and TRAIL Receptors in Allergic Asthmatics Following Segmental Antigen Challenge: Evidence for a Role of TRAIL in Eosinophil Survival1 , 2002, The Journal of Immunology.
[85] Joseph H. Nadeau,et al. The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs , 2000, Nature Genetics.
[86] K. Totpal,et al. Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety. , 2001, The Journal of pharmacology and experimental therapeutics.
[87] R. Gentz,et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. , 1997, Science.
[88] M. V. D. van den Brink,et al. Nature's TRAIL--on a path to cancer immunotherapy. , 2003, Immunity.
[89] B. Hylander,et al. The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice , 2005, Journal of Translational Medicine.
[90] C. Dinney,et al. Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT-mediated X-linked inhibitor of apoptosis protein expression. , 2007, Cancer research.
[91] S. Fulda,et al. 5-Aza-2′-deoxycytidine and IFN-γ cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8 , 2006, Oncogene.
[92] M. Smyth,et al. Eradication of established tumors in mice by a combination antibody-based therapy , 2006, Nature Medicine.
[93] Ron Korstanje,et al. From QTL to gene: the harvest begins , 2002, Nature Genetics.
[94] K. Matsushima,et al. Regulation of tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and TRAIL receptor expression in human neutrophils , 2004, Immunology.
[95] P. Donnelly,et al. Association mapping in structured populations. , 2000, American journal of human genetics.
[96] C. Rauch,et al. Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo , 1999, Nature Medicine.
[97] W I Wood,et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. , 1997, Science.
[98] Daniel R. Richards,et al. Dissecting the architecture of a quantitative trait locus in yeast , 2002, Nature.
[99] M. Smyth,et al. Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Contributes to Interferon γ–Dependent Natural Killer Cell Protection from Tumor Metastasis , 2001, The Journal of experimental medicine.
[100] Christoph H Emmerich,et al. TRAIL signalling: decisions between life and death. , 2007, The international journal of biochemistry & cell biology.
[101] Xiangwei Wu,et al. Bypass NF-κB-mediated survival pathways by TRAIL and Smac , 2007 .
[102] R. K Srivastava,et al. Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer , 2001, Oncogene.
[103] Michael Weller,et al. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo , 2002, Nature Medicine.
[104] S. Belinsky,et al. 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway. , 2006, Cancer research.
[105] K. Schooley,et al. Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) , 1999, The Journal of experimental medicine.
[106] M. Fiscella,et al. HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo , 2005, British Journal of Cancer.
[107] Xuetao Cao,et al. Involvement of tumour necrosis factor‐α‐related apoptosis‐inducing ligand in enhanced cytotoxicity of lipopolysaccharide‐stimulated dendritic cells to activated T cells , 2002, Immunology.
[108] E. Khavkin,et al. Mapped genomic locations for developmental functions and QTLs reflect concerted groups in maize (Zea mays L.) , 1997, Theoretical and Applied Genetics.
[109] M. Won,et al. Complestatin prevents apoptotic cell death: inhibition of a mitochondrial caspase pathway through AKT/PKB activation. , 2004, Biochemical and biophysical research communications.
[110] S. Shankar,et al. Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: Intracellular mechanisms , 2004, The Prostate.
[111] S. Marsters,et al. Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family* , 1996, The Journal of Biological Chemistry.
[112] Thomas Mitchell-Olds,et al. Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[113] A. Gurney,et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain , 1997, Current Biology.
[114] Kazuyuki Doi,et al. Ehd1, a B-type response regulator in rice, confers short-day promotion of flowering and controls FT-like gene expression independently of Hd1. , 2004, Genes & development.
[115] Yong J. Lee,et al. TRAIL apoptosis is enhanced by quercetin through Akt dephosphorylation , 2007, Journal of cellular biochemistry.
[116] T L Chenevert,et al. Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[117] T. Sayers,et al. Induction of Tumor-specific T Cell Immunity by Anti-DR5 Antibody Therapy , 2004, The Journal of experimental medicine.
[118] Y. Yoo,et al. Antitumor Activity of TRAIL Recombinant Adenovirus in Human Malignant Glioma Cells , 2005, Journal of Korean medical science.
[119] Cécile Viboud,et al. Multinational impact of the 1968 Hong Kong influenza pandemic: evidence for a smoldering pandemic. , 2005, The Journal of infectious diseases.
[120] B. Gliniak,et al. Tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo is enhanced by the chemotherapeutic agent CPT-11. , 1999, Cancer research.
[121] L. Cardon,et al. Association study designs for complex diseases , 2001, Nature Reviews Genetics.
[122] S. Ray,et al. S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11–induced apoptosis of prostate cancer cells , 2007, Molecular Cancer Therapeutics.
[123] S. Henikoff,et al. Efficient discovery of DNA polymorphisms in natural populations by Ecotilling. , 2004, The Plant journal : for cell and molecular biology.
[124] Andreas Untergasser,et al. Preclinical Differentiation between Apparently Safe and Potentially Hepatotoxic Applications of TRAIL Either Alone or in Combination with Chemotherapeutic Drugs , 2006, Clinical Cancer Research.
[125] Michael T. Fisher,et al. Molecular determinants of response to TRAIL in killing of normal and cancer cells. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[126] Afshin Samali,et al. TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt , 2006, British Journal of Cancer.
[127] L. Andĕra,et al. Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo , 2007, British Journal of Cancer.
[128] M. Andreeff,et al. Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL‐R1 and TRAIL‐R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin‐ and bortezomib‐induced cell death , 2005, British journal of haematology.
[129] I. Pollack,et al. Direct stimulation of apoptotic signaling by soluble Apo2l/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[130] T. Okanoue,et al. Soluble TRAIL gene and actinomycin D synergistically suppressed multiple metastasis of TRAIL-resistant colon cancer in the liver. , 2007, Cancer letters.
[131] E. Henson,et al. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFκB activation in epithelial derived cell lines , 2002, Apoptosis.
[132] H. Leung,et al. Tagging quantitative loci controlling pathogenicity in Magnaporthe grisea by insertional mutagenesis , 2002 .
[133] S. Toyooka,et al. Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types , 2004, International journal of cancer.
[134] T. C. Nesbitt,et al. fw2.2: a quantitative trait locus key to the evolution of tomato fruit size. , 2000, Science.
[135] R. Schwabe,et al. TRAIL‐mediated apoptosis requires NF‐kB inhibition and the mitochondrial permeability transition in human hepatoma cells , 2002 .
[136] K. Mather. Variation and selection of polygenic characters , 2008, Journal of Genetics.
[137] A. Levy,et al. Transcriptional activation of retrotransposons alters the expression of adjacent genes in wheat , 2003, Nature Genetics.
[138] J. Herman,et al. Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation. , 2002, Cancer research.
[139] J. Cleveland,et al. Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels. , 2007, Cancer research.
[140] R. Zeillinger,et al. Contribution of Epigenetic Silencing of Tumor Necrosis Factor–Related Apoptosis Inducing Ligand Receptor 1 (DR4) to TRAIL Resistance and Ovarian Cancer , 2005, Molecular Cancer Research.
[141] K. Okumura,et al. Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs , 1999, The Journal of experimental medicine.
[142] S. Shankar,et al. Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo. , 2003, Cancer research.
[143] W. El-Deiry,et al. Death Domain Mutagenesis of KILLER/DR5 Reveals Residues Critical for Apoptotic Signaling* , 2001, The Journal of Biological Chemistry.
[144] M. Manns,et al. Telomerase-dependent virotherapy overcomes resistance of hepatocellular carcinomas against chemotherapy and tumor necrosis factor-related apoptosis-inducing ligand by elimination of Mcl-1. , 2005, Cancer research.
[145] M. Sporn,et al. Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL , 2003, Leukemia.
[146] K. Tyler,et al. Reovirus-Induced Apoptosis Is Mediated by TRAIL , 2000, Journal of Virology.
[147] B. Hylander,et al. Multiple mechanisms underlie resistance of leukemia cells to Apo2 Ligand/TRAIL , 2006, Molecular Cancer Therapeutics.
[148] Lifen Gao,et al. Hepatitis B Virus Sensitizes Hepatocytes to TRAIL-Induced Apoptosis through Bax1 , 2007, The Journal of Immunology.
[149] S. Tanksley,et al. Advanced backcross QTL analysis: a method for the simultaneous discovery and transfer of valuable QTLs from unadapted germplasm into elite breeding lines , 1996, Theoretical and Applied Genetics.
[150] M. Zivy,et al. Genetics of proteome variation for QTL characterization: application to drought-stress responses in maize , 1999 .
[151] S. Curley,et al. Antitumor activity and bystander effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene. , 2001, Cancer research.
[152] Peter M. Waterhouse,et al. Exploring plant genomes by RNA-induced gene silencing , 2003, Nature Reviews Genetics.
[153] J. Tschopp,et al. Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes , 2003, Cell.
[154] N. Mitsiades,et al. Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5. , 2001, Cancer research.
[155] C. Belka,et al. Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo , 2006, Oncogene.
[156] Rachel B. Brem,et al. The landscape of genetic complexity across 5,700 gene expression traits in yeast. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[157] Tae-Jin Lee,et al. Acquired TRAIL resistance in human breast cancer cells are caused by the sustained cFLIP(L) and XIAP protein levels and ERK activation. , 2006, Biochemical and biophysical research communications.
[158] Henning Walczak,et al. TRAIL‐R2: a novel apoptosis‐mediating receptor for TRAIL , 1997, The EMBO journal.
[159] S. Salvi,et al. Validation and characterization of a major QTL affecting leaf ABA concentration in maize , 2005, Molecular Breeding.
[160] P. Secchiero,et al. Tumour necrosis factor‐related apoptosis‐inducing ligand sequentially activates pro‐survival and pro‐apoptotic pathways in SK‐N‐MC neuronal cells , 2003, Journal of neurochemistry.
[161] M. Smyth,et al. Cutting Edge: TRAIL Deficiency Accelerates Hematological Malignancies1 , 2005, The Journal of Immunology.
[162] P. Richardson,et al. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. , 2001, Blood.
[163] K. Selmaj,et al. TRAIL‐induced death of human adult oligodendrocytes is mediated by JNK pathway , 2006, Glia.
[164] J. Vose,et al. Results of a Phase 2 Trial of HGS-ETR1 (Agonistic Human Monoclonal Antibody to TRAIL Receptor 1) in Subjects with Relapsed/Refractory Non-Hodgkin’s Lymphoma (NHL). , 2005 .
[165] Trudy F C Mackay,et al. The genetic architecture of quantitative traits: lessons from Drosophila. , 2004, Current opinion in genetics & development.
[166] D. Pental,et al. Molecular tagging of erucic acid trait in oilseed mustard (Brassica juncea) by QTL mapping and single nucleotide polymorphisms in FAE1 gene , 2004, Theoretical and Applied Genetics.
[167] K. Okumura,et al. Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity. , 1999, Journal of immunology.
[168] M. Smyth,et al. Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice1 , 2002, The Journal of Immunology.
[169] V. Cryns,et al. Peroxisome Proliferator-activated Receptor γ Agonists Promote TRAIL-induced Apoptosis by Reducing Survivin Levels via Cyclin D3 Repression and Cell Cycle Arrest* , 2005, Journal of Biological Chemistry.
[170] K. D. Patterson,et al. Pandemic influenza, 1700-1900 : a study in historical epidemiology , 1986 .
[171] S. Kaeppler,et al. Tissue culture-induced DNA methylation variation in maize. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[172] B. Bonavida,et al. X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: sensitization by overexpression of second mitochondria-derived activator of caspase/direct IAP-bi , 2002, Molecular cancer therapeutics.
[173] Emad S. Alnemri,et al. Temperature-sensitive Differential Affinity of TRAIL for Its Receptors , 2000, The Journal of Biological Chemistry.
[174] S. Tanksley,et al. A new class of regulatory genes underlying the cause of pear-shaped tomato fruit , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[175] G. An,et al. Gene tagging in rice: a high throughput system for functional genomics. , 2001, Plant science : an international journal of experimental plant biology.
[176] L. Kruglyak,et al. Genetic Dissection of Transcriptional Regulation in Budding Yeast , 2002, Science.
[177] John Calvin Reed,et al. FLIP protein and TRAIL-induced apoptosis. , 2004, Vitamins and hormones.
[178] D. McCarty,et al. Molecular analysis of high-copy insertion sites in maize. , 2004, Nucleic acids research.
[179] N. Andrews,et al. Original Contribution Investigation of the Temporal Association of Guillain-Barré Syndrome With Influenza Vaccine and Influenzalike Illness Using the United Kingdom General Practice Research Database , 2009 .
[180] J. Burrow. A History of Histories: Epics, Chronicles, Romances and Inquiries from Herodotus and Thucydides to the Twentieth Century , 2007 .
[181] M. Smyth,et al. Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development , 2002, The Journal of experimental medicine.
[182] T. Sayers,et al. Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy , 2005, Cancer Immunology, Immunotherapy.
[183] H. Joo,et al. Expression of TRAIL (TNF-related apoptosis-inducing ligand) receptors in cervical cancer. , 2000, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.
[184] F. Martinon,et al. Activation of a pro‐apoptotic amplification loop through inhibition of NF‐κB‐dependent survival signals by caspase‐mediated inactivation of RIP , 2000, FEBS letters.
[185] W. Stremmel,et al. Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs , 2004, Cell Death and Differentiation.
[186] P. Hersey,et al. The histone deacetylase inhibitor suberic bishydroxamate: a potential sensitizer of melanoma to TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis. , 2003, Biochemical pharmacology.
[187] Robin Foà,et al. TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL. , 2005, Haematologica.
[188] J. Bruner,et al. TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation , 2005, Apoptosis.
[189] J. Partanen,et al. c‐Myc primed mitochondria determine cellular sensitivity to TRAIL‐induced apoptosis , 2007, The EMBO journal.
[190] S. S. Strom,et al. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions , 2001, Nature Medicine.
[191] M. Shin,et al. Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma , 2001, Oncogene.
[192] C. Voelkel-Johnson. An Antibody Against DR4 (TRAIL-R1) in Combination with Doxorubicin Selectively Kills Malignant but not Normal Prostate Cells , 2003, Cancer biology & therapy.
[193] H. Hollema,et al. Expression of TRAIL (TNF‐related apoptosis‐inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas , 2003, The Journal of pathology.
[194] H. Friess,et al. The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract , 1999, Oncogene.
[195] D. Zamir. Improving plant breeding with exotic genetic libraries , 2001, Nature Reviews Genetics.
[196] H. Koeppen,et al. Isotype-Dependent Inhibition of Tumor Growth In Vivo by Monoclonal Antibodies to Death Receptor 4 , 2001, The Journal of Immunology.
[197] P. Hersey,et al. Differential Localization and Regulation of Death and Decoy Receptors for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Human Melanoma Cells1 , 2000, The Journal of Immunology.
[198] A. Younes,et al. Emerging Applications of the Tumor Necrosis Factor Family of Ligands and Receptors in Cancer Therapy , 2003 .
[199] T. Shiraishi,et al. Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells. , 2005, Cancer research.
[200] Karen Billeci,et al. Receptor-selective Mutants of Apoptosis-inducing Ligand 2/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Reveal a Greater Contribution of Death Receptor (DR) 5 than DR4 to Apoptosis Signaling* , 2005, Journal of Biological Chemistry.
[201] J. Nadeau,et al. Finding Genes That Underlie Complex Traits , 2002, Science.
[202] C. Calatozzolo,et al. In vitro effects of topotecan and ionizing radiation on TRAIL/Apo2L-mediated apoptosis in malignant glioma , 2004, Journal of Neuro-Oncology.
[203] M. Fiscella,et al. Monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) induces apoptosis in primary renal cell carcinoma cells in vitro and inhibits tumor growth in vivo. , 2006, International journal of oncology.
[204] Wafik S El-Deiry,et al. Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[205] Yeon-Woo Ryu,et al. Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors. , 2005, Biochemical and biophysical research communications.
[206] Y. Mizutani,et al. Gene therapy with TRAIL against renal cell carcinoma , 2006, Molecular Cancer Therapeutics.
[207] Ronald W. Lewis,et al. Sensitization of TRAIL–resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin , 2006, Molecular Cancer Therapeutics.
[208] R. Schmidt. Synteny: recent advances and future prospects. , 2000, Current opinion in plant biology.
[209] T. Whiteside,et al. Innate Direct Anticancer Effector Function of Human Immature Dendritic Cells. II. Role of TNF, Lymphotoxin-α1β2, Fas Ligand, and TNF-Related Apoptosis-Inducing Ligand1 , 2002, The Journal of Immunology.
[210] M Koornneef,et al. Naturally occurring variation in Arabidopsis: an underexploited resource for plant genetics. , 2000, Trends in plant science.
[211] P. Hersey,et al. Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types , 2000, FEBS letters.
[212] B. Vandenbunder,et al. Rel/NF-κB Transcription Factors Protect against Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by Up-regulating the TRAIL Decoy Receptor DcR1* , 2001, The Journal of Biological Chemistry.
[213] T. Sayers,et al. Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer. , 2003, Cancer research.
[214] H. Hollema,et al. Tissue Distribution of the Death Ligand TRAIL and Its Receptors , 2004, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[215] R. Mauricio. Mapping quantitative trait loci in plants: uses and caveats for evolutionary biology , 2001, Nature Reviews Genetics.
[216] M. Biffoni,et al. A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells. , 2007, Gynecologic oncology.
[217] C. Hardtke,et al. Natural genetic variation in Arabidopsis identifies BREVIS RADIX , a novel regulator of cell proliferation and elongation in the root , 2004 .