Pain management in patients with opioid induced constipation – case report

Opioid induced constipation may be caused by any opioid analgesics, in spite of their type and route of administration. In this paper, there was reported a case of a patient with opioid-induced constipation induced by transdermal fentanyl. Its switch to oxycodone/naloxone controlled release tablets provided analgesic effectiveness and restored proper bowel function.

[1]  Karolin Baecker.  Handbook Of Opioid Bowel Syndrome , 2016 .

[2]  T. Dzierżanowski,et al.  Behavioral risk factors of constipation in palliative care patients , 2014, Supportive Care in Cancer.

[3]  P. Stone,et al.  Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC. , 2012, The Lancet. Oncology.

[4]  Diana Gosálvez Prados.  The European Association for Palliative Care (EAPC) , 2010 .

[5]  G. Pasternak,et al.  Opioid receptors and opioid pharmacodynamics , 2009 .

[6]  C. Sweeney,et al.  Assessment and management of opioid side effects , 2009 .

[7]  C. Aurilio,et al.  Buprenorphine in long-term control of chronic pain in cancer patients. , 2007, Frontiers in bioscience : a journal and virtual library.

[8]  M. Ueberall,et al.  656 OPIOID‐INDUCED CONSTIPATION — A FREQUENT AND DISTRESSING SIDE EFFECT IN DAILY PRACTICE AFFECTING ORAL AND TRANSDERMAL OPIOID APPLICATIONS , 2006 .

[9]  R. Williams,et al.  (960): Constipation is a predominant side effect of opioid treatment for persistent pain , 2006 .

[10]  T. Bell,et al.  (959): The incidence and impact of gastrointestinal adverse events (GIAEs) associated with opioid analgesic use: A review of the literature , 2006 .

[11]  S. Ahmedzai,et al.  Efficacy and safety of transdermal fentanyl and sustained-release oral morphine in patients with cancer and chronic non-cancer pain , 2004, Current medical research and opinion.

[12]  P. Staats,et al.  Incidence of Constipation Associated with Long-acting Opioid Therapy: A Comparative Study , 2004, Southern medical journal.

[13]  C. Wilder-Smith,et al.  Effect of Tramadol and Morphine on Pain and Gastrointestinal Motor Function in Patients with Chronic Pancreatitis , 1999, Digestive Diseases and Sciences.

[14]  D. Sessler,et al.  Opioid-induced bowel dysfunction: pathophysiology and potential new therapies. , 2003, Drugs.

[15]  M Pappagallo,et al.  Incidence, prevalence, and management of opioid bowel dysfunction. , 2001, American journal of surgery.

[16]  M. Storr,et al.  Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum , 2000, Neuropeptides.

[17]  L. Radbruch,et al.  High-dose tramadol in comparison to low-dose morphine for cancer pain relief. , 1999, Journal of pain and symptom management.

[18]  M. Citron,et al.  Controlled‐release oxycodone compared with controlled‐release morphine in the treatment of cancer pain: A randomized, double‐blind, parallel‐group study , 1998, European journal of pain.

[19]  R. Williams,et al.  Quality of life and cancer pain: satisfaction and side effects with transdermal fentanyl versus oral morphine. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[20]  E. Kalso,et al.  Epidural and subcutaneous morphine in the management of cancer pain: a double-blind cross-over study , 1996, Pain.

[21]  A. Dzien,et al.  Treatment of severe cancer pain by low-dose continuous subcutaneous morphine , 1989, Pain.

[22]  B. Krevsky,et al.  Role of opiate receptors in the regulation of colonic transit. , 1988, Gastroenterology.