Associations of autozygosity with a broad range of human phenotypes

Peter K. Joshi | M. P. Concas | May E. Montasser | Cassandra N. Spracklen | Annelot M. Dekker | Blair H. Smith | P. Elliott | M. Nalls | C. Gieger | M. Waldenberger | I. Deary | J. Pankow | R. Mägi | D. Lawlor | T. Lumley | D. Gudbjartsson | U. Thorsteinsdóttir | K. Stefánsson | H. Hakonarson | S. Grant | E. Boerwinkle | J. Rioux | V. Salomaa | M. Perola | C. Rotimi | A. Adeyemo | C. Wijmenga | L. Groop | M. Laakso | F. Collins | Z. Kutalik | M. Johannesson | M. Boehnke | M. Kanai | Y. Kamatani | Y. Okada | P. Ridker | D. Chasman | P. Munroe | M. Caulfield | N. Timpson | W. Sheu | I. Lee | D. Bennett | V. Gudnason | D. Shriner | M. Schulze | C. Bouchard | F. Grodstein | S. Chanock | John Wright | J. Jonas | A. Zonderman | M. Evans | E. Tai | T. Merriman | J. Whitfield | K. Matsuda | F. Rivadeneira | P. Sulem | Gardar Sveinbjornsson | G. Másson | G. Thorleifsson | S. Kardia | J. Kaprio | J. Erdmann | T. Meitinger | D. Tregouet | W. Lieb | H. Schunkert | C. Haiman | P. Kraft | A. Stanton | S. Wild | H. Huikuri | N. Sattar | A. Metspalu | T. Esko | A. Doumatey | G. Montgomery | L. Milani | K. Fischer | S. London | C. Meisinger | L. Scott | K. Mohlke | A. Doney | T. Tuomi | K. Taylor | J. Rotter | J. Bradfield | C. Aguilar-Salinas | W. März | P. Jousilahti | C. Ober | T. Harris | I. Rudan | D. Posthuma | M. Swertz | Jian-Min Yuan | W. Koh | J. Brody | N. Sotoodehnia | D. Porteous | A. Pattie | J. Starr | M. Germain | P. Morange | L. H. van den Berg | J. Veldink | D. Becker | D. Nyholt | S. Berndt | L. Bielak | P. Peyser | N. Wareham | Jianjun Liu | A. Mahajan | A. Hamsten | P. Magnusson | L. Franke | C. Haley | A. Helgason | D. Bharadwaj | P. D. De Jager | Xiuqing Guo | C. Sabanayagam | J. Jukema | R. Schmidt | H. Schmidt | G. Matullo | C. Schurmann | A. Teumer | U. Völker | S. Medland | K. North | M. Ikram | J. Corley | S. Harris | C. Heng | A. Franke | R. Lea | L. Griffiths | L. Orozco | L. Straker | I. Jansen | S. Carmi | J. van Setten | Patrick Deelen | K. Ong | J. Kooner | E. Bottinger | S. Rich | S. Hunt | C. A. Rietveld | N. Amin | C. Hayward | P. Joshi | I. Kolčić | J. Lahti | O. Polašek | Jennifer A. Smith | V. Vitart | H. Campbell | J. Faul | L. Launer | K. Räikkönen | F. V. van Rooij | P. Vollenweider | D. Weir | James F. Wilson | D. Cesarini | L. Pérusse | G. Smith | B. Zemel | M. Feitosa | N. Franceschini | Ching-Yu Cheng | X. Sim | A. Bentley | T. Bartz | R. Dorajoo | S. Tajuddin | A. Campbell | Jin-Fang Chai | J. Luan | N. Matoba | I. Nolte | S. Padmanabhan | A. Robino | A. Stančáková | P. J. van der Most | H. Warren | L. Yanek | T. Aung | M. Brumat | R. de Mutsert | E. Evangelou | Y. Friedlander | I. Gandin | He Gao | S. Hagenaars | M. Hirata | C. Khor | J. Kuusisto | C. Langenberg | B. Lehne | M. Loh | Y. Momozawa | J. O'connell | N. Poulter | W. Scott | Yuan Shi | Yih-Chung Tham | Lihua Wang | Y. X. Wang | J. Chambers | B. Freedman | P. Gasparini | A. Oldehinkel | P. van der Harst | R. V. van Dam | D. Mook-Kanamori | W. Palmas | A. Morrison | T. Kacprowski | M. Laudes | A. Shuldiner | Anuradha Jagadeesan | S. Ebenesersdóttir | R. Strawbridge | M. Cornelis | B. Sennblad | C. Palmer | K. Khaw | Å. Johansson | M. Kleber | M. Goodarzi | A. Hicks | Y. Hung | M. Kumari | J. Zhao | M. Bochud | U. Gyllensten | C. Hsiung | P. Pramstaller | D. Sanghera | I. Tzoulaki | Zhengming Chen | Yu Guo | Liming Li | F. Day | P. Goyette | D. Ellinghaus | D. V. van Heel | C. Fuchsberger | M. Mezzavilla | F. Azizi | H. Boeing | K. Dhana | V. Jaddoe | M. Nauck | M. Lerch | M. Dörr | R. Ewert | E. Salvi | D. Cusi | B. Feenstra | C. Medina-Gomez | S. Trompet | S. W. van der Laan | G. Delgado | J. Junttila | Yingchang Lu | N. Verweij | S. Bakker | H. D. den Ruijter | P. Manunta | G. Pasterkamp | F. Asselbergs | M. Graff | M. Allison | L. Broer | M. Cocca | G. D. de Borst | G. Girotto | Yucheng Jia | F. Karpe | R. Li-Gao | K. Meidtner | M. Neville | C. Pennell | Kevin Sandow | Carol A. Wang | T. Polderman | Jinyan Huang | P. Sever | S. Guarrera | A. Murray | R. Prasad | K. V. van Eijk | L. Quintana-Murci | M. Bixley | G. Chandak | H. Moreno-Macías | A. Manichaikul | N. Dzimiri | N. Kerrison | E. Hofer | B. Krämer | M. Hedayati | R. Tracy | M. Albert | E. Patin | M. Gögele | C. Pattaro | W. Meng | D. Toniolo | Y. Bao | M. Smart | Y. Chiu | J. Mychaleckyj | M. Akiyama | Guanjie Chen | W. van Rheenen | Jié Zhou | D. Cousminer | L. Skotte | N. Pirastu | Y. Murakami | T. Nutile | M. Chee | T. Corre | J. Felix | H. Mattsson | M. Sabater-Lleal | F. Rizzi | C. Viberti | M. Pirastu | R. Karlsson | C. Sala | Wen-Jane Lee | D. D. de Kleijn | A. Halevy | M. Concas | M. Ciullo | D. Ruggiero | G. Biino | D. Mason | N. Small | E. Vuoksimaa | G. Cugliari | Adele M Taylor | Clicerio Gonzalez | S. Loomis | C. Baumbach | Jingyun Yang | Bjarni Gunnarsson | S. Vaccargiu | D. Eccles | I. Millwood | R. Walters | A. Damulina | R. Wootton | A. Huerta-Chagoya | T. Muka | Kuang Lin | Constance Turman | B. Meyer | J. Vangipurapu | T. Kessler | Lingyao Zeng | M. Daneshpour | T. Palviainen | M. Munz | Y. Saba | H. D. de Haan | C. Yajnik | J. Borja | Annika Tillander | B. Sapkota | C. Spracklen | H. Hochner | Catriona L. K. Barnes | A. van der Spek | C. Igartua | S. Foisy | Jennifer A. Brody | Smeeta Shrestha | Tallapragada Divya Sri Priyanka | G. Wander | S. Ralhan | Rebecca Rohde | S. Wakil | N. Terzikhan | N. Yousri | Peter J. van der Most | Traci M. Bartz | Shengchao A Li | Liang Zhang | J. Singh | L. Stefánsdóttir | J. Elliott | E. Granot-Hershkovitz | K. H. Moore | Kamran Guity | J. Yao | Gauri Prasad | X. Mei | S. Shukla | Amy Moore | Maris Alver | S. Afaq | Franco Giulianini | Y. Chen | D. Clark | J. Sigurdsson | G. Pálsson | Timo Tõnis Sikka | B. Sedaghati-khayat | Imo Höfer | Lei Yu | A. Smith | T. Karlsson | Weihua Zhang | A. Uitterlinden | Teresa Tusié-Luna | Wei Zhao | D. Rao | A. Goel | M. Kubo | J. Eriksson | C. V. van Duijn | J. Perry | S. Gordon | B. Psaty | Trevor A. Mori | R. Loos | R. Scott | M. McCarthy | T. Wong | N. Martin | S. Harris | R. Scott | N. Martin | M. McCarthy | R. Schmidt | Wei Zhao | Hannele Mattsson | A. Campbell | D. Clark | C. Palmer | Rebecca R. Rohde | Jennifer A. Smith | K. Taylor | I. Höfer | T. Wong | Martin Gögele | Jeffery R O'connell | D. Bennett | Alicia Huerta-Chagoya | Einat Granot-Hershkovitz | K. Moore | Ruifang Li-Gao

[1]  M. Keller,et al.  Relationships between estimated autozygosity and complex traits in the UK Biobank , 2018, bioRxiv.

[2]  P. Hedrick,et al.  How should we compare different genomic estimates of the strength of inbreeding depression? , 2018, Proceedings of the National Academy of Sciences.

[3]  Peter K. Joshi,et al.  Runs of homozygosity: windows into population history and trait architecture , 2018, Nature Reviews Genetics.

[4]  Naomi R. Wray,et al.  Detection and quantification of inbreeding depression for complex traits from SNP data , 2017, Proceedings of the National Academy of Sciences.

[5]  David Reich,et al.  The promise of disease gene discovery in South Asia , 2017, Nature Genetics.

[6]  Daniel G. MacArthur,et al.  Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity , 2017, Nature.

[7]  Andrew P Morris,et al.  Guidance for the utility of linear models in meta-analysis of genetic association studies of binary phenotypes , 2016, European Journal of Human Genetics.

[8]  Jonathan P. Beauchamp,et al.  Genome-wide association study identifies 74 loci associated with educational attainment , 2016, Nature.

[9]  L. Kruuk,et al.  Inbreeding depression across the lifespan in a wild mammal population , 2016, Proceedings of the National Academy of Sciences.

[10]  Harry Hemingway,et al.  Health and population effects of rare gene knockouts in adult humans with related parents , 2015, Science.

[11]  Laura J. Scott,et al.  Directional dominance on stature and cognition in diverse human populations , 2015, Nature.

[12]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[13]  P. Sullivan,et al.  Educational Attainment Influences Levels of Homozygosity through Migration and Assortative Mating , 2015, PloS one.

[14]  P. Elliott,et al.  UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.

[15]  T. Berra,et al.  Darwin was right: inbreeding depression on male fertility in the Darwin family , 2015 .

[16]  Carson C Chow,et al.  Second-generation PLINK: rising to the challenge of larger and richer datasets , 2014, GigaScience.

[17]  E. Génin,et al.  Inbreeding Coefficient Estimation with Dense SNP Data: Comparison of Strategies and Application to HapMap III , 2014, Human Heredity.

[18]  P. Sullivan,et al.  Association Between Autozygosity and Major Depression: Stratification Due to Religious Assortment , 2013, Behavior genetics.

[19]  Yurii S. Aulchenko,et al.  Region-Based Association Analysis of Human Quantitative Traits in Related Individuals , 2013, PloS one.

[20]  Richard M Myers,et al.  Genomic patterns of homozygosity in worldwide human populations. , 2012, American journal of human genetics.

[21]  Lorna M. Lopez,et al.  Evidence of Inbreeding Depression on Human Height , 2012, PLoS genetics.

[22]  P. Visscher,et al.  Quantification of Inbreeding Due to Distant Ancestors and Its Detection Using Dense Single Nucleotide Polymorphism Data , 2011, Genetics.

[23]  P. Visscher,et al.  GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.

[24]  Harry Campbell,et al.  Genomic Runs of Homozygosity Record Population History and Consanguinity , 2010, PloS one.

[25]  Josyf Mychaleckyj,et al.  Robust relationship inference in genome-wide association studies , 2010, Bioinform..

[26]  Wolfgang Viechtbauer,et al.  Conducting Meta-Analyses in R with the metafor Package , 2010 .

[27]  A. Bittles,et al.  Evolution in health and medicine Sackler colloquium: Consanguinity, human evolution, and complex diseases. , 2010, Proceedings of the National Academy of Sciences of the United States of America.

[28]  D. Charlesworth,et al.  The genetics of inbreeding depression , 2009, Nature Reviews Genetics.

[29]  B. Toupance,et al.  Impact of inbreeding on fertility in a pre-industrial population , 2009, European Journal of Human Genetics.

[30]  Igor Rudan,et al.  Runs of homozygosity in European populations. , 2008, American journal of human genetics.

[31]  K. Stefánsson,et al.  An Association Between the Kinship and Fertility of Human Couples , 2008, Science.

[32]  Todd Lencz,et al.  Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia , 2007, Proceedings of the National Academy of Sciences.

[33]  J. Weber,et al.  Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits. , 2007, Human molecular genetics.

[34]  D. Buss,et al.  Strategies of Human Mating , 2006 .

[35]  N. Morton,et al.  Extended tracts of homozygosity in outbred human populations. , 2006, Human molecular genetics.

[36]  L. Keller,et al.  Inbreeding effects in wild populations. , 2002 .

[37]  R. Hussain,et al.  Does inbreeding lead to decreased human fertility? , 2002, Annals of human biology.

[38]  J. Slate,et al.  Comparing molecular measures for detecting inbreeding depression , 2002 .

[39]  J. Slate,et al.  MICROSATELLITE LOCI REVEAL SEX‐DEPENDENT RESPONSES TO INBREEDING AND OUTBREEDING IN RED DEER CALVES , 1999, Evolution; international journal of organic evolution.

[40]  J. Weber,et al.  Long homozygous chromosomal segments in reference families from the centre d'Etude du polymorphisme humain. , 1999, American journal of human genetics.

[41]  J. Bashi Effects of inbreeding on cognitive performance , 1977, Nature.

[42]  E. C. Fieller SOME PROBLEMS IN INTERVAL ESTIMATION , 1954 .

[43]  W. Hauck,et al.  Inbreeding effects on fertility in humans: evidence for reproductive compensation. , 1999, American journal of human genetics.

[44]  D. Buss The Evolution Of Desire: Strategies of Human Mating , 1994 .

[45]  Jay L. Lush,et al.  The genetics of populations , 1948 .