Randomized controlled trial of postoperative radiotherapy and short‐term time‐scheduled 5‐fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer

Background The purpose of the present study was to investigate whether a 1‐month regimen of postoperative radiotherapy combined with 5‐fluorouracil could reduce the local recurrence rate and improve survival in patients with Dukes B and C rectal cancer.

[1]  R. Aitken,et al.  Mesorectal excision for rectal cancer , 1996, The British journal of surgery.

[2]  H. Johansson,et al.  The Stockholm I trial of preoperative short term radiotherapy in operable rectal carcinoma , 1995, Cancer.

[3]  H. Wieand,et al.  Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. , 1994, The New England journal of medicine.

[4]  G. Duchesne.  Chemoradiation. An Integrated Approach to Cancer Treatment , 1994, British Journal of Cancer.

[5]  J. Macfarlane,et al.  Mesorectal excision for rectal cancer , 1993, The Lancet.

[6]  A. Chen,et al.  Antimetabolites , 1992, Cancer chemotherapy and biological response modifiers.

[7]  G. Murray,et al.  Statistical aspects of research methodology , 1991, The British journal of surgery.

[8]  W. Meyers,et al.  Effective surgical adjuvant therapy for high-risk rectal carcinoma. , 1991, The New England journal of medicine.

[9]  B. Kimler,et al.  5-Fluorouracil modulation of radiosensitivity in cultured human carcinoma cells. , 1991, International journal of radiation oncology, biology, physics.

[10]  A. Horn,et al.  Low‐dose preoperative radiation postpones recurrences in operable rectal cancer: Results of a randomized multicenter trial in western norway , 1990, Cancer.

[11]  B. Trock,et al.  Randomized trials of adjuvant radiation therapy for rectal carcinoma: A review , 1990, Diseases of the colon and rectum.

[12]  D. Galloway,et al.  Adjuvant multimodality treatment of rectal cancer , 1989, The British journal of surgery.

[13]  M. Buyse,et al.  Preoperative Radiotherapy as Adjuvant Treatment in Rectal Cancer: Final Results of a Randomized Study of the European Organization for Research and Treatment of Cancer (EORTC) , 1988, Annals of surgery.

[14]  W. P. Dixon,et al.  BMPD statistical software manual , 1988 .

[15]  M. Buyse,et al.  Adjuvant therapy of colorectal cancer. Why we still don't know. , 1988, JAMA.

[16]  H. Rockette,et al.  Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01. , 1988, Journal of the National Cancer Institute.

[17]  D. Stablein,et al.  Survival after postoperative combination treatment of rectal cancer. , 1986, The New England journal of medicine.

[18]  J. Overgaard,et al.  Postoperative radiotherapy in Dukes' B and C carcinoma of the rectum and rectosigmoid: A randomized multicenter study , 1986, Cancer.

[19]  J. Byfield,et al.  Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-Fluorouracil or ftorafur and X rays. , 1982, International journal of radiation oncology, biology, physics.

[20]  Y. Nakajima,et al.  Enhancement of mammalian cell killing by 5-fluorouracil in combination with X-rays. , 1979, Cancer research.

[21]  M. Pike,et al.  Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. , 1977, British Journal of Cancer.

[22]  B. Kimler,et al.  Mammalian cell heterogeneity to modulation of radiosensittvity by 5-flracil , 1990 .

[23]  Prolongation of the disease-free interval in surgically treated rectal carcinoma. , 1985, The New England journal of medicine.

[24]  G. Steel,et al.  Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. , 1979, International journal of radiation oncology, biology, physics.

[25]  D. Cox.  Regression Models and Life-Tables , 1972 .

[26]  D.,et al.  Regression Models and Life-Tables , 2022 .