Systematic review: evidence‐based management of hepatocellular carcinoma – an updated analysis of randomized controlled trials

The treatment strategy of hepatocellular carcinoma applied following scientific guidelines is only supported by 77 randomized controlled trials published so far, a figure that clearly pinpoints hepatocellular carcinoma as an ‘orphan’ cancer in terms of clinical research when compared with other high‐prevalent cancers worldwide.

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[31]  T. Mok,et al.  Results of a phase 2/3 open-label, randomized trial of T138067 versus doxorubicin (DOX) in chemotherapy-naïve, unresectable hepatocellular carcinoma (HCC). , 2005 .

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[33]  Yi-Cheng Chen,et al.  Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma < or =4 cm. , 2004, Gastroenterology.

[34]  J. Bruix,et al.  Initial response to percutaneous ablation predicts survival in patients with hepatocellular carcinoma , 2004, Hepatology.

[35]  S. Fan,et al.  A randomized placebo‐controlled study of long‐acting octreotide for the treatment of advanced hepatocellular carcinoma , 2002, Hepatology.

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[41]  John Wong,et al.  Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma , 2002, Hepatology.

[42]  D. Guyader,et al.  Prospective randomized trial of chemoembolization versus intra‐arterial injection of 131I‐labeled–iodized oil in the treatment of hepatocellular carcinoma , 1997, Hepatology.