Distinct modes of functional connectivity induced by movie-watching

&NA; A fundamental question in systems neuroscience is how endogenous neuronal activity self‐organizes during particular brain states. Recent neuroimaging studies have demonstrated systematic relationships between resting‐state and task‐induced functional connectivity (FC). In particular, continuous task studies, such as movie watching, speak to alterations in coupling among cortical regions and enhanced fluctuations in FC compared to the resting‐state. This suggests that FC may reflect systematic and large‐scale reorganization of functionally integrated responses while subjects are watching movies. In this study, we characterized fluctuations in FC during resting‐state and movie‐watching conditions. We found that the FC patterns induced systematically by movie‐watching can be explained with a single principal component. These condition‐specific FC fluctuations overlapped with inter‐subject synchronization patterns in occipital and temporal brain regions. However, unlike inter‐subject synchronization, condition‐specific FC patterns were characterized by increased correlations within frontal brain regions and reduced correlations between frontal‐parietal brain regions. We investigated these condition‐specific functional variations as a shorter time scale, using time‐resolved FC. The time‐resolved FC showed condition‐specificity over time; notably when subjects watched both the same and different movies. To explain self‐organisation of global FC through the alterations in local dynamics, we used a large‐scale computational model. We found that condition‐specific reorganization of FC could be explained by local changes that engendered changes in FC among higher‐order association regions, mainly in frontal and parietal cortices. HighlightsThe variations of functional connectivity during movie‐watching condition are explained by a single principal component.The topography of condition‐specific principal component is similar to inter‐subject synchronization in occipital and temporal brain regions, but it exhibits distinct patterns expressed in frontal brain regions.Time‐resolved functional connectivity shows that the condition‐specific functional states are continuous across time.A whole‐brain computational model shows that the changes in local dynamical properties in higher‐order association regions can explain the condition‐specific changes in FC.

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