Interobserver variability in radiation therapy plan output: Results of a single-institution study.

PURPOSE We investigated the sources of variability in radiation therapy treatment plan output between planners within a single institution. METHODS AND MATERIALS Forty treatment planners across 5 campuses of an institution created a plan on the same thoracic esophagus patient computed tomography scan and structure set. Plans were scored and ranked based on the planner's adherence to an ordered list of target dose coverage and normal tissue evaluation criteria. A runs test was used to identify whether any of the studied planner qualities influenced the ranking. Spearman rank correlation was used to investigate whether plan score correlated with years of experience or planned monitor units. RESULTS The distribution of scores, ranging from 80.24 to 135.89, was negatively skewed (mean, 128.7; median, 131.5). No statistically significant relationship between plan score and campus (P = .193), job title (P = .174), previous outside experience (P = .611), or number of gantry angles (P = .156) was discovered. No statistical correlation between plan score and monitor unit or years of experience was found. CONCLUSIONS Despite clear and established critical organ dose criteria and well-documented planning guidelines, planning variation still occurs, even among members of the same institution. Because plan consistency does not seem to significantly correlate with experience, career path, or campus, investigation into alternate methods beyond additional education and training to reduce this variation, such as knowledge-based planning or advanced optimization techniques, is necessary.

[1]  T. Hashimoto,et al.  Analysis of dose-volume histogram parameters for radiation pneumonitis after definitive concurrent chemoradiotherapy for esophageal cancer. , 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[2]  P E Metcalfe,et al.  Multicentre quality assurance of intensity-modulated radiation therapy plans: a precursor to clinical trials. , 2007, Australasian radiology.

[3]  D. Low,et al.  Experience-based quality control of clinical intensity-modulated radiotherapy planning. , 2011, International Journal of Radiation Oncology, Biology, Physics.

[4]  Adam P Dicker,et al.  Radiotherapy protocol deviations and clinical outcomes: a meta-analysis of cooperative group clinical trials. , 2013, Journal of the National Cancer Institute.

[5]  Michael G Jameson,et al.  How important is dosimetrist experience for intensity modulated radiation therapy? A comparative analysis of a head and neck case. , 2013, Practical radiation oncology.

[6]  Sasa Mutic,et al.  Quantifying Unnecessary Normal Tissue Complication Risks due to Suboptimal Planning: A Secondary Study of RTOG 0126. , 2015, International journal of radiation oncology, biology, physics.

[7]  J. V. Bradley Distribution-Free Statistical Tests , 1968 .

[8]  D. Followill,et al.  Does quality of radiation therapy predict outcomes of multicenter cooperative group trials? A literature review. , 2013, International journal of radiation oncology, biology, physics.

[9]  B. Farrús,et al.  Primary small cell carcinoma of the esophagus , 1997, Cancer.

[10]  James Wheeler,et al.  Variation in external beam treatment plan quality: An inter-institutional study of planners and planning systems. , 2012, Practical radiation oncology.

[11]  Russell H. Taylor,et al.  Data-driven approach to generating achievable dose-volume histogram objectives in intensity-modulated radiotherapy planning. , 2011, International journal of radiation oncology, biology, physics.

[12]  Debra H Brinkmann,et al.  Incidence of radiation pneumonitis after thoracic irradiation: Dose-volume correlates. , 2007, International journal of radiation oncology, biology, physics.

[13]  Christopher G Willett,et al.  Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas. , 2012, International journal of radiation oncology, biology, physics.

[14]  Masahiro Endo,et al.  Predictive value of dose-volume histogram parameters for predicting radiation pneumonitis after concurrent chemoradiation for lung cancer. , 2003, International journal of radiation oncology, biology, physics.

[15]  Fernando Alonso,et al.  Intensity-modulated radiotherapy – a large scale multi-criteria programming problem , 2003, OR Spectr..

[16]  J. Lo,et al.  A knowledge-based approach to improving and homogenizing intensity modulated radiation therapy planning quality among treatment centers: an example application to prostate cancer planning. , 2013, International journal of radiation oncology, biology, physics.

[17]  Nicholas G Zaorsky,et al.  Radiotherapy and chemotherapy are associated with improved outcomes over surgery and chemotherapy in the management of limited-stage small cell esophageal carcinoma. , 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[18]  Marta Paiusco,et al.  IMRT treatment planning:- a comparative inter-system and inter-centre planning exercise of the ESTRO QUASIMODO group. , 2005, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[19]  D. McShan,et al.  Lexicographic ordering: intuitive multicriteria optimization for IMRT , 2007, Physics in medicine and biology.

[20]  J. Reason Human error: models and management , 2000, BMJ : British Medical Journal.

[21]  Joe Y. Chang,et al.  The prevalence of myocardial ischemia after concurrent chemoradiation therapy as detected by gated myocardial perfusion imaging in patients with esophageal cancer. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[22]  Y. Ge,et al.  Quantitative analysis of the factors which affect the interpatient organ-at-risk dose sparing variation in IMRT plans. , 2012, Medical physics.

[23]  David L Craft,et al.  Approximating convex pareto surfaces in multiobjective radiotherapy planning. , 2006, Medical physics.

[24]  T Kairn,et al.  Examination of the properties of IMRT and VMAT beams and evaluation against pre-treatment quality assurance results , 2015, Physics in medicine and biology.

[25]  Joseph O Deasy,et al.  IMRT treatment planning based on prioritizing prescription goals , 2007, Physics in medicine and biology.

[26]  G. Gualco,et al.  [Primary small cell carcinoma of the esophagus]. , 1995, Acta gastroenterologica Latinoamericana.