Körperliche Aktivität und Sport bei Typ-2-Diabetes Physical Activity and Sports in Patients With Type 2 Diabetes

A sufficient amount of physical activity is an important tool to prevent and treat type 2 diabetes. Beside an improvement in glycemic control, beneficial effects of physical activity and exercise training include a reduction of the cardiovascular risk profile, body weight and ectopic fat stores, anti-inflammatory properties and also an increase of physical fitness. In this context, exercise training lowers all-cause and cardiac mortality in type 2 diabetes. Actual recommendations reflect that adults with type 2 diabetes should be advised to perform at least 150min per week of moderate intensive aerobic exercise training (50 – 70% maximum heart rate). The training activity should be spread over at least three sessions during a week, and resting periods between the sessions should not exceed two days. In addition, in the absence of contraindications, adults with type 2 diabetes should be encouraged to perform resistance training at a minimum of twice a week. Moreover, a reduction of sedentary time by breaking up periods of sitting longer than 90 minutes should be realized. Risks during exercise training can arise from a non-optimal glycemic control. Moreover, long-term complications of diabetes such a retinopathy, autonomic neuropathy and coronary heart disease may lower tolerance to exercise. Thus, a pretraining evaluation and clinical judgement should be performed. If necessary, the training regimen has to be adapted to the individual case. To avoid hypoglycemia in patients treated with insulin or secretagogues, the medication dose has to be adapted individually and/or additional carbohydrates supplemented, if pre-exercise plasma glucose is measured below 100mg/dl.

[1]  R. Wing,et al.  Four-Year Physical Activity Levels among Intervention Participants with Type 2 Diabetes. , 2016, Medicine and science in sports and exercise.

[2]  R. MacIsaac,et al.  Does a single bout of resistance or aerobic exercise after insulin dose reduction modulate glycaemic control in type 2 diabetes? A randomised cross-over trial. , 2016, Journal of science and medicine in sport.

[3]  Morten Wang Fagerland,et al.  Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women , 2016, The Lancet.

[4]  S. Zipfel,et al.  Have adults lost their sense of play? An observational study of the social dynamics of physical (in)activity in German and Hawaiian leisure settings , 2016, BMC Public Health.

[5]  P. Schrauwen,et al.  Effects of exercise training on intrahepatic lipid content in humans , 2016, Diabetologia.

[6]  Daniel P. Bailey,et al.  Breaking up prolonged sitting time with walking does not affect appetite or gut hormone concentrations but does induce an energy deficit and suppresses postprandial glycaemia in sedentary adults. , 2016, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[7]  M. Donath Multiple benefits of targeting inflammation in the treatment of type 2 diabetes , 2016, Diabetologia.

[8]  B. Pedersen,et al.  Preview : Published ahead of advance online publication Exercise and type 2 diabetes : Focus on metabolism and inflammation , 2015 .

[9]  Glen P. Kenny,et al.  Body temperature regulation in diabetes , 2016, Temperature.

[10]  H. Häring,et al.  Exercise and diabetes: relevance and causes for response variability , 2015, Endocrine.

[11]  W. Kraus,et al.  The effects of exercise on the lipoprotein subclass profile: A meta-analysis of 10 interventions. , 2015, Atherosclerosis.

[12]  Kamlesh Khunti,et al.  Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study , 2015, Diabetes Care.

[13]  Courtney V. Farland,et al.  The Effects of High Intensity Interval Training vs Steady State Training on Aerobic and Anaerobic Capacity. , 2015, Journal of sports science & medicine.

[14]  M. Laughlin,et al.  Endurance, interval sprint, and resistance exercise training: impact on microvascular dysfunction in type 2 diabetes. , 2015, American journal of physiology. Heart and circulatory physiology.

[15]  M. Pasnoor,et al.  Pilot Study of Exercise Therapy on Painful Diabetic Peripheral Neuropathy. , 2015, Pain medicine.

[16]  C. Ayers,et al.  Metabolic Effects of Exercise Training Among Fitness-Nonresponsive Patients With Type 2 Diabetes: The HART-D Study , 2015, Diabetes Care.

[17]  D. Alter,et al.  Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults , 2015, Annals of Internal Medicine.

[18]  Stephan C. Bischoff,et al.  Prävention und Therapie der Adipositas , 2014, Diabetologie und Stoffwechsel.

[19]  David Wilkins,et al.  Systematic reviews of and integrated report on the quantitative, qualitative and economic evidence base for the management of obesity in men. , 2014, Health technology assessment.

[20]  A. Farmer,et al.  Resistance Exercise Versus Aerobic Exercise for Type 2 Diabetes: A Systematic Review and Meta-Analysis , 2014, Sports Medicine.

[21]  S. Fukuhara,et al.  Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: a meta-analysis of randomized controlled trials. , 2014, Metabolism: clinical and experimental.

[22]  Jennette P. Moreno,et al.  Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes , 2014, Current Atherosclerosis Reports.

[23]  Ulrik Wisløff,et al.  High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis , 2013, British Journal of Sports Medicine.

[24]  F. Hartgens,et al.  Effect of Moderate-Intensity Exercise Versus Activities of Daily Living on 24-Hour Blood Glucose Homeostasis in Male Patients With Type 2 Diabetes , 2013, Diabetes Care.

[25]  T. Perry,et al.  Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: a randomized crossover trial. , 2013, The American journal of clinical nutrition.

[26]  A. Vinik,et al.  Exercise improves cardiac autonomic function in obesity and diabetes. , 2013, Metabolism: clinical and experimental.

[27]  S. Aunola,et al.  Improved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomised Finnish Diabetes Prevention Study (DPS) , 2013, Diabetologia.

[28]  J. Ribeiro,et al.  Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis , 2013, Diabetologia.

[29]  S. Sisson,et al.  The Potential for High-Intensity Interval Training to Reduce Cardiometabolic Disease Risk , 2012, Sports Medicine.

[30]  S. Fukuhara,et al.  Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. , 2012, Diabetes research and clinical practice.

[31]  U. Ekelund,et al.  Global physical activity levels: surveillance progress, pitfalls, and prospects , 2012, The Lancet.

[32]  K. Häkkinen,et al.  Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence? , 2012, PloS one.

[33]  R. Pop-Busui What Do We Know and We Do Not Know About Cardiovascular Autonomic Neuropathy in Diabetes , 2012, Journal of Cardiovascular Translational Research.

[34]  Edward H Ip,et al.  Lifestyle change and mobility in obese adults with type 2 diabetes. , 2012, The New England journal of medicine.

[35]  H. Kohl,et al.  Long-Term Effects of Changes in Cardiorespiratory Fitness and Body Mass Index on All-Cause and Cardiovascular Disease Mortality in Men: The Aerobics Center Longitudinal Study , 2012 .

[36]  W. Kraus,et al.  Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. , 2011, American journal of physiology. Endocrinology and metabolism.

[37]  H. Fischer Diabetes, Sport und Bewegung , 2011 .

[38]  G. Caimi,et al.  Effects of exercise on inflammation markers in type 2 diabetic subjects , 2011, Acta Diabetologica.

[39]  Jonathan D. Bartlett,et al.  High-intensity interval running is perceived to be more enjoyable than moderate-intensity continuous exercise: Implications for exercise adherence , 2011, Journal of sports sciences.

[40]  J. E. West,et al.  Is Poor Fitness Contagious? Evidence from Randomly Assigned Friends , 2010 .

[41]  K. Courneya,et al.  Protection motivation theory and the prediction of physical activity among adults with type 1 or type 2 diabetes in a large population sample. , 2010, British journal of health psychology.

[42]  J. Duarte,et al.  Is exercise training an effective therapy targeting endothelial dysfunction and vascular wall inflammation? , 2010, International journal of cardiology.

[43]  S. Blair,et al.  Long-Term Trends in Cardiorespiratory Fitness and the Incidence of Type 2 Diabetes , 2010, Diabetes Care.

[44]  J. Laitinen,et al.  Barriers to regular exercise among adults at high risk or diagnosed with type 2 diabetes: a systematic review. , 2009, Health promotion international.

[45]  M. Fortier,et al.  Understanding physical activity in adults with type 2 diabetes after completing an exercise intervention trial: A mediation model of self-efficacy and autonomous motivation , 2009, Psychology, health & medicine.

[46]  F. Schick,et al.  High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease , 2008, Gut.

[47]  U. Wisløff,et al.  Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome: A Pilot Study , 2008, Circulation.

[48]  Christoph Handschin,et al.  The role of exercise and PGC1α in inflammation and chronic disease , 2008, Nature.

[49]  Eve Roelker,et al.  Screening for Coronary Artery Disease in Patients With Diabetes , 2008 .

[50]  D. Stewart,et al.  Physical Activity Behavior, Motivational Readiness and Self-Efficacy among Ontarians with Cardiovascular Disease and Diabetes , 2007, Journal of Behavioral Medicine.

[51]  J. Wojtaszewski,et al.  Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise , 2006, The Journal of physiology.

[52]  J. Adams,et al.  High-intensity interval training for intermittent claudication in a vascular rehabilitation program. , 2006, Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing.

[53]  David M Nathan,et al.  Psychological predictors of physical activity in the diabetes prevention program. , 2006, Journal of the American Dietetic Association.

[54]  J. Tuomilehto,et al.  Physical activity, cardiovascular risk factors, and mortality among Finnish adults with diabetes. , 2005, Diabetes care.

[55]  S. Fowler,et al.  Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program. , 2005, Diabetes care.

[56]  M. Stumvoll,et al.  Reduced skeletal muscle oxygen uptake and reduced beta-cell function: two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes. , 2003, Diabetes care.

[57]  Alison Kirk,et al.  Increasing physical activity in people with type 2 diabetes. , 2003, Diabetes care.

[58]  V. Ricca,et al.  Adherence to structured physical exercise in overweight and obese subjects: A review of psychological models , 2003, Eating and weight disorders : EWD.

[59]  Edward J Boyko,et al.  Diet and exercise among adults with type 2 diabetes: findings from the third national health and nutrition examination survey (NHANES III). , 2002, Diabetes care.

[60]  E. Henriksen Invited review: Effects of acute exercise and exercise training on insulin resistance. , 2002, Journal of applied physiology.

[61]  C. Bouchard,et al.  Individual differences in response to regular physical activity. , 2001, Medicine and science in sports and exercise.

[62]  Carol Ewing Garber,et al.  ACSM Position Stand: The Recommended Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory and Muscular Fitness, and Flexibility in Healthy Adults , 1998 .

[63]  G. Schuler,et al.  Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease. , 2010, European heart journal.

[64]  L. Goodyear,et al.  Exercise, MAPK, and NF-kappaB signaling in skeletal muscle. , 2007, Journal of applied physiology.

[65]  Y. Jang,et al.  Standards of Medical Care in Diabetes-2010 by the American Diabetes Association: Prevention and Management of Cardiovascular Disease , 2010 .

[66]  S. Blair,et al.  Exercise capacity and body composition as predictors of mortality among men with diabetes. , 2004, Diabetes care.

[67]  J. Hawley,et al.  Improvements in insulin resistance with aerobic exercise training: a lipocentric approach. , 2004, Medicine and science in sports and exercise.

[68]  I. Piña,et al.  Resistance Exercise in Individuals With and Without Cardiovascular Disease Benefits, Rationale, Safety, and Prescription An Advisory From the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association , 2000 .