Concurrent occurrence of chronic lymphocytic thyroiditis with hypothyroidism and growth hormone deficiency in a Turner’s syndrome patient

Background: Concurrent defi ciencies of three hormones in patients with Turner’s syndrome (TS) have rarely been reported. Here, we describe a case of a young girl who had Turner ’ s syndrome with concomitant chronic lymphocytic thyroiditis, growth hormone defi ciency, and hypothyroidism with cardiopericarditis. Case: An 11-year-old girl was referred to the outpatient clinic because of short stature, ochriasis, and cardiopalmus. Her ultrasound revealed absence of ovarian tissue. Karyotype examination suggested Turner ’ s syndrome with sex hormone defi ciency. She was found to have an abnormal thyroid gland and elevated thyroid stimulating hormone (TSH). A positive thyroid autoantibody titer confi rmed the diagnosis of chronic lymphocytic thyroiditis with hypothyroidism. Furthermore, her growth hormone levels were well below normal. Diagnosis : A multi-endocrine disorder, i.e., Turner ’ s syndrome with chronic lymphocytic thyroiditis, growth hormone defi ciency, and hypothyroidism with cardiopericarditis was diagnosed. Growth hormone and thyroxin substitution therapy was suggested.