A Rapid Approach for the Optimisation of Polymer Supported Reagents in Synthesis

The technique of Design of Experiments (DoE) was em- ployed to facilitate the rapid automated optimisation of amide for- mation using a polymer supported carbodiimide system. Using an optimised set of reaction conditions, an array of 80 compounds was synthesised in a 96-well plate with the reagent being delivered via an IRORI‰ kan to each individual well.