Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum

[1]  S. Horvath,et al.  Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients , 2015, Aging.

[2]  S. Horvath,et al.  Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring , 2015, Aging.

[3]  M. Levine,et al.  Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning , 2015, Aging.

[4]  J. Vaupel,et al.  University of Southern Denmark DNA methylation age is associated with mortality in a longitudinal Danish twin study , 2015 .

[5]  A. Brunet,et al.  Epigenetic regulation of ageing: linking environmental inputs to genomic stability , 2015, Nature Reviews Molecular Cell Biology.

[6]  S. Horvath,et al.  HIV-1 Infection Accelerates Age According to the Epigenetic Clock , 2015, The Journal of infectious diseases.

[7]  Jennifer S. Woo,et al.  The cerebellum ages slowly according to the epigenetic clock , 2015, Aging.

[8]  B. Morris,et al.  FOXO3: A Major Gene for Human Longevity - A Mini-Review , 2015, Gerontology.

[9]  Michael C O'Donovan,et al.  Methylomic trajectories across human fetal brain development , 2015, Genome research.

[10]  Steve Horvath,et al.  Accelerated epigenetic aging in Down syndrome , 2015, Aging cell.

[11]  Manolis Kellis,et al.  Large-scale epigenome imputation improves data quality and disease variant enrichment , 2015, Nature Biotechnology.

[12]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[13]  S. Horvath,et al.  DNA methylation age of blood predicts all-cause mortality in later life , 2015, Genome Biology.

[14]  Steve Horvath,et al.  The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 , 2015, International journal of epidemiology.

[15]  Gustavo Turecki,et al.  Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia , 2014, Genome Biology.

[16]  Steve Horvath,et al.  Obesity accelerates epigenetic aging of human liver , 2014, Proceedings of the National Academy of Sciences.

[17]  A. Singleton,et al.  Genetic variability in the regulation of gene expression in ten regions of the human brain , 2014, Nature Neuroscience.

[18]  D. Bennett,et al.  Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease , 2014, Nature Neuroscience.

[19]  L. Siever,et al.  A unique gene expression signature associated with serotonin 2C receptor RNA editing in the prefrontal cortex and altered in suicide. , 2014, Human molecular genetics.

[20]  Naomi R. Wray,et al.  Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples , 2014, PLoS genetics.

[21]  Ross M. Fraser,et al.  A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness , 2014, PLoS genetics.

[22]  Jutta Gampe,et al.  Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age , 2014, Human molecular genetics.

[23]  Nick C Fox,et al.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.

[24]  S. Horvath.  DNA methylation age of human tissues and cell types , 2013, Genome Biology.

[25]  Ulf Gyllensten,et al.  Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan , 2013, PloS one.

[26]  Gabriëlle H S Buitendijk,et al.  Seven New Loci Associated with Age-Related Macular Degeneration , 2013, Nature Genetics.

[27]  Lan Ye,et al.  Rapalogs and mTOR inhibitors as anti-aging therapeutics. , 2013, The Journal of clinical investigation.

[28]  P. Rabinovitch,et al.  mTOR is a key modulator of ageing and age-related disease , 2013, Nature.

[29]  J. Marchini,et al.  Fast and accurate genotype imputation in genome-wide association studies through pre-phasing , 2012, Nature Genetics.

[30]  Raymond K. Auerbach,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[31]  G. Satten,et al.  Age-associated DNA methylation in pediatric populations. , 2012, Genome research.

[32]  J. Kleinman,et al.  DNA methylation signatures in development and aging of the human prefrontal cortex. , 2012, American journal of human genetics.

[33]  Howard Y. Chang,et al.  Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock , 2012, Cell.

[34]  A. Uitterlinden,et al.  Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited , 2011, Aging cell.

[35]  Mark R Cookson,et al.  Distinct DNA methylation changes highly correlated with chronological age in the human brain. , 2011, Human molecular genetics.

[36]  P. Visscher,et al.  Estimating missing heritability for disease from genome-wide association studies. , 2011, American journal of human genetics.

[37]  Timothy J. Durham,et al.  "Systematic" , 1966, Comput. J..

[38]  Ayellet V. Segrè,et al.  Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits , 2010, PLoS genetics.

[39]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[40]  Luigi Ferrucci,et al.  Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain , 2010, PLoS genetics.

[41]  Wolfgang Wagner,et al.  Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. , 2010, Genome research.

[42]  Owen T McCann,et al.  Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. , 2010, Genome research.

[43]  Lijun Cheng,et al.  Genetic control of individual differences in gene-specific methylation in human brain. , 2010, American journal of human genetics.

[44]  Sonja W. Scholz,et al.  Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease , 2009, Nature Genetics.

[45]  Marco Pahor,et al.  Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.

[46]  P. Donnelly,et al.  A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies , 2009, PLoS genetics.

[47]  Stefan Schreiber,et al.  Association of FOXO3A variation with human longevity confirmed in German centenarians , 2009, Proceedings of the National Academy of Sciences.

[48]  S. Horvath,et al.  WGCNA: an R package for weighted correlation network analysis , 2008, BMC Bioinformatics.

[49]  Katsuhiko Yano,et al.  FOXO3A genotype is strongly associated with human longevity , 2008, Proceedings of the National Academy of Sciences.

[50]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[51]  Manel Esteller,et al.  Epigenetics and aging: the targets and the marks. , 2007, Trends in genetics : TIG.

[52]  D. Reich,et al.  Principal components analysis corrects for stratification in genome-wide association studies , 2006, Nature Genetics.

[53]  Kaare Christensen,et al.  The quest for genetic determinants of human longevity: challenges and insights , 2006, Nature Reviews Genetics.

[54]  Matt Kaeberlein,et al.  Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients , 2005, Science.

[55]  Tibor Vellai,et al.  Genetics: Influence of TOR kinase on lifespan in C. elegans , 2003, Nature.

[56]  Tanya M. Teslovich,et al.  LocusZoom: regional visualization of genome-wide association scan results , 2010, Bioinform..

[57]  I. Ial,et al.  Nature Communications , 2010, Nature Cell Biology.