Residual Radiation Risk Disparities Across Sex and Race or Ethnic Groups for Lifetime Never-Smokers on Lunar Missions

In the current decade missions to the Earths moon are of scientific and societal interest, however pose the problem of risks of late effects for returning crew persons, most importantly cancer and circulatory diseases. In this paper, we discuss NSCR-2022 model risk estimates for lunar missions for US racial and ethnic groups comparing never-smokers to US averages for each group and sex. We show that differences within groups between men and women are largely reduced for NS compared to the average population. Race and ethnic group dependent cancer and circulatory disease risks are reduced by 10% to 40% for NS with the largest decrease for Whites. Circulatory disease risks are changed by less than 10% for NS and in several cases modestly increased due to increased lifespan for NS. Asian-Pacific Islander (API) and Hispanics NS are at lower risk compared to Whites and Blacks. Differences between groups is narrowed for NS compared to predictions for average populations, however disparities remain especially for Blacks and to a lesser extent Whites compared to API or Hispanic NS groups.

[1]  F. Cucinotta Non-Targeted Effects and Space Radiation Risks for Astronauts on Multiple International Space Stations and Lunar Missions , 2023, medRxiv.

[2]  A. Einstein,et al.  Ionising radiation and cardiovascular disease: systematic review and meta-analysis , 2023, BMJ.

[3]  N. Freedman,et al.  Mortality Relative Risks by Smoking, Race/Ethnicity, and Education. , 2023, American journal of preventive medicine.

[4]  Alana D. Steffen,et al.  Associations in Cigarette Smoking and Health Conditions by Race/Ethnicity Among a Diverse Sample of Patients Receiving Treatment in a Federally Qualified Health Care Setting in Chicago , 2023, Health equity.

[5]  A. Jemal,et al.  Association Between Smoking, Smoking Cessation, and Mortality by Race, Ethnicity, and Sex Among US Adults , 2022, JAMA network open.

[6]  Ahmed Jamal,et al.  Tobacco Product Use Among Adults — United States, 2020 , 2022, MMWR. Morbidity and mortality weekly report.

[7]  Francis A Cucinotta,et al.  A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection. , 2021, Life sciences in space research.

[8]  F. Cucinotta Flying without a Net: Space Radiation Cancer Risk Predictions without a Gamma-ray Basis , 2021, medRxiv.

[9]  H. Sugiyama,et al.  Radiation Risk of Ovarian Cancer in Atomic Bomb Survivors: 1958–2009 , 2020, Radiation Research.

[10]  H. Sugiyama,et al.  Risk of Prostate Cancer Incidence among Atomic Bomb Survivors: 1958–2009 , 2020, Radiation Research.

[11]  Sam S. Chang Re: Smoking Cessation: A Report of the Surgeon General. , 2020, The Journal of urology.

[12]  H. Sugiyama,et al.  Radiation risk of central nervous system tumors in the Life Span Study of atomic bomb survivors, 1958–2009 , 2020, European Journal of Epidemiology.

[13]  H. Sugiyama,et al.  Radiation-Related Risk of Cancers of the Upper Digestive Tract among Japanese Atomic Bomb Survivors. , 2019, Radiation research.

[14]  H. Sugiyama,et al.  Radiation and Risk of Liver, Biliary Tract, and Pancreatic Cancers among Atomic Bomb Survivors in Hiroshima and Nagasaki: 1958-2009. , 2019, Radiation research.

[15]  H. Sugiyama,et al.  Radiation risk of incident colorectal cancer by anatomical site among atomic bomb survivors: 1958–2009 , 2019, International journal of cancer.

[16]  H. Sugiyama,et al.  Incidence of Breast Cancer in the Life Span Study of Atomic Bomb Survivors: 1958–2009 , 2018, Radiation Research.

[17]  J. Clayton,et al.  Applying the new SABV (sex as a biological variable) policy to research and clinical care , 2017, Physiology & Behavior.

[18]  F. Cucinotta,et al.  Non-Targeted Effects Models Predict Significantly Higher Mars Mission Cancer Risk than Targeted Effects Models , 2017, Scientific Reports.

[19]  F. Cucinotta,et al.  Predictions of space radiation fatality risk for exploration missions. , 2017, Life sciences in space research.

[20]  D. Pierce,et al.  Lung, Laryngeal and Other Respiratory Cancer Incidence among Japanese Atomic Bomb Survivors: An Updated Analysis from 1958 through 2009 , 2017, Radiation Research.

[21]  Javier Gómez-Elvira,et al.  Comparison of Martian surface ionizing radiation measurements from MSL‐RAD with Badhwar‐O'Neill 2011/HZETRN model calculations , 2014 .

[22]  Francis A. Cucinotta,et al.  Space Radiation Risks for Astronauts on Multiple International Space Station Missions , 2014, PloS one.

[23]  Michael J Thun,et al.  50-year trends in smoking-related mortality in the United States. , 2013, The New England journal of medicine.

[24]  Minli Wang,et al.  Radiation Carcinogenesis Risk Assessments for Never-smokers , 2012, Health physics.

[25]  D. L. Preston,et al.  Solid Cancer Incidence in Atomic Bomb Survivors: 1958–1998 , 2007, Radiation research.

[26]  Douglas Midthune,et al.  Modeling Reporting Delays and Reporting Corrections in Cancer Registry Data , 2005 .

[27]  R. Doll,et al.  Mortality in relation to smoking: 50 years' observations on male British doctors , 2004, BMJ : British Medical Journal.

[28]  Leif E. Peterson,et al.  Space Radiation Cancer Risks and Uncertainties for Mars Missions , 2001, Radiation research.

[29]  Richard Wakeford,et al.  Uncertainties in Fatal Cancer Risk Estimates Used in Radiation Protection , 1998 .

[30]  J. Wilson,et al.  Galactic cosmic ray transport methods: past, present, and future. , 1994, Advances in space research : the official journal of the Committee on Space Research.

[31]  C. Lushbaugh Guidance on Radiation Received in Space Activities , 1990 .