Structure-Function Elucidation of a New (cid:2) -Conotoxin, Lo1a, from Conus longurionis

Background: (cid:2) -Conotoxins are small toxins produced by cone snails and antagonists of nicotinic acetylcholine receptors. Results: Two mutants were created to investigate the unusual C terminus of a novel (cid:2) -conotoxin from Conus longurionis . Conclusion: We characterized an important residue for discrimination between neuronal and muscle subtype nicotinic acetylcholine receptors. Significance: This opens perspectives for designing new ligands to affect brain disorders. (cid:2) -Conotoxins are peptide toxins found in the venom of marine cone snails and potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs).

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