Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria

Aims  To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria.

[1]  Olivier Bouchaud,et al.  Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base , 2009, Malaria Journal.

[2]  K. Silamut,et al.  Artemisinin resistance in Plasmodium falciparum malaria. , 2009, The New England journal of medicine.

[3]  V. Carey,et al.  Mixed-Effects Models in S and S-Plus , 2001 .

[4]  R. Woosley,et al.  Mechanism of cardiotoxicity of halofantrine , 2000, Clinical pharmacology and therapeutics.

[5]  A. B. Simonetti The biology of malarial parasite in the mosquito--a review. , 1996, Memorias do Instituto Oswaldo Cruz.

[6]  B. Ripley,et al.  Modern Applied Statistics with S-Plus. , 1996 .

[7]  D. Neau,et al.  Cardiac complications of halofantrine: a prospective study of 20 patients. , 1995, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[8]  H. Webster,et al.  Pharmacokinetics of an extended‐dose halofantrine regimen in patients with malaria and in healthy volunteers , 1995, Clinical pharmacology and therapeutics.

[9]  H. Webster,et al.  Comparison of capillary whole blood, venous whole blood, and plasma concentrations of mefloquine, halofantrine, and desbutyl-halofantrine measured by high-performance liquid chromatography. , 1994, The American journal of tropical medicine and hygiene.

[10]  J. Karbwang,et al.  Clinical Pharmacokinetics of Halofantrine , 1994, Clinical pharmacokinetics.

[11]  Adrian F. M. Smith,et al.  Bayesian Analysis of Linear and Non‐Linear Population Models by Using the Gibbs Sampler , 1994 .

[12]  A. Cowman,et al.  Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[13]  H. Webster,et al.  Halofantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria , 1993, The Lancet.

[14]  D. Kyle,et al.  Cardiac effects of antimalarial treatment with halofantrine , 1993, The Lancet.

[15]  G. Casella,et al.  Explaining the Gibbs Sampler , 1992 .

[16]  G. Edwards,et al.  Pharmacokinetics of halofantrine in healthy Thai volunteers [letter] , 1991 .

[17]  S. Ward,et al.  Pharmacokinetics of halofantrine in Thai patients with acute uncomplicated falciparum malaria. , 1991, British journal of clinical pharmacology.

[18]  D. Bates,et al.  Nonlinear mixed effects models for repeated measures data. , 1990, Biometrics.

[19]  A. Breckenridge,et al.  Pharmacokinetics of halofantrine in man: effects of food and dose size. , 1989, British journal of clinical pharmacology.

[20]  T L Lai,et al.  Sequential medical trials. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[21]  D. Brocks,et al.  The stereoselective metabolism of halofantrine to desbutylhalofantrine in the rat: evidence of tissue-specific enantioselectivity in microsomal metabolism. , 2007, Chirality.

[22]  K. Rieckmann,et al.  Pharmacokinetics of halofantrine and n-desbutylhalofantrine in patients with falciparum malaria following a multiple dose regimen of halofantrine , 2004, European Journal of Clinical Pharmacology.

[23]  Douglas M. Bates,et al.  Programming With Data: A Guide to the S Language , 1999, Technometrics.

[24]  J. Deharo,et al.  Is halofantrine still advisable in malaria attacks? , 1997, Annals of tropical medicine and parasitology.

[25]  K. Cowles,et al.  CODA: convergence diagnosis and output analysis software for Gibbs sampling output , 1995 .

[26]  J. Le bras,et al.  Antimalarial activity in vitro of the N-desbutyl derivative of halofantrine. , 1992, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[27]  H. Webster,et al.  An improved high-performance liquid chromatographic method for the simultaneous measurement of halofantrine and desbutylhalofantrine in human serum. , 1991, Therapeutic drug monitoring.

[28]  N. White,et al.  Malaria on the Thai-Burmese border: treatment of 5192 patients with mefloquine-sulfadoxine-pyrimethamine. , 1987, Bulletin of the World Health Organization.