Biodegradation and removal of pharmaceuticals and personal care products in treatment systems: a review

Pharmaceuticals and personal care products (PPCPs) have been the focus of much recent research as concerns rise about their occurrence in bodies of water worldwide. In an effort to characterize the risk and determine the prevalence of these micropollutants in lakes and rivers, many researchers are examining PPCP removal from impaired water during wastewater treatment and water recycling (soil passage) processes. Biodegradation studies and projects considering combinations of biodegradation and other removal processes have been conducted over a wide range of compound categories and therapeutic classes, as well as across different systems and scales of study. This review summarizes the extent of PPCP removal observed in these various systems.

[1]  R. Stuetz,et al.  The Fate and Removal of Triclosan during Wastewater Treatment , 2005, Water environment research : a research publication of the Water Environment Federation.

[2]  T. Ternes,et al.  Pharmaceuticals and personal care products in the environment: agents of subtle change? , 1999, Environmental health perspectives.

[3]  Víctor Matamoros,et al.  Behaviour of pharmaceutical products and biodegradation intermediates in horizontal subsurface flow constructed wetland. A microcosm experiment. , 2008, The Science of the total environment.

[4]  E. Thurman,et al.  Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. , 2002 .

[5]  A. Sapkota,et al.  Partitioning, persistence, and accumulation in digested sludge of the topical antiseptic triclocarban during wastewater treatment. , 2006, Environmental science & technology.

[6]  M. Carballa,et al.  Behaviour of pharmaceuticals and personal care products in a sewage treatment plant of northwest Spain. , 2005, Water science and technology : a journal of the International Association on Water Pollution Research.

[7]  Marta Carballa,et al.  Fate of pharmaceutical and personal care products (PPCPs) during anaerobic digestion of sewage sludge. , 2007, Water research.

[8]  P. Zhou,et al.  Treatment of High-Strength Pharmaceutical Wastewater and Removal of Antibiotics in Anaerobic and Aerobic Biological Treatment Processes , 2006 .

[9]  Heinz P Singer,et al.  Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface waters. , 2003, Environmental science & technology.

[10]  B. Venables,et al.  Triclosan in a North Texas wastewater treatment plant and the influent and effluent of an experimental constructed wetland , 2006, Environmental toxicology and chemistry.

[11]  Joan Oppenheimer,et al.  Characterizing the Passage of Personal Care Products Through Wastewater Treatment Processes , 2007, Water environment research : a research publication of the Water Environment Federation.

[12]  D. Calamari,et al.  Removal of pharmaceuticals in sewage treatment plants in Italy. , 2006, Environmental science & technology.

[13]  Gilles Klopman,et al.  Structure–biodegradability study and computer‐automated prediction of aerobic biodegradation of chemicals , 1997 .

[14]  Thomas Steger-Hartmann,et al.  Biodegradability of the anti-tumour agent ifosfamide and its occurrence in hospital effluents and communal sewage , 1997 .

[15]  K. Armbrust,et al.  Laboratory persistence and fate of fluoxetine in aquatic environments , 2006, Environmental toxicology and chemistry.

[16]  K. Linge,et al.  Occurrence of iodinated X-ray contrast media in indirect potable reuse systems , 2010, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[17]  M. Jekel,et al.  OCCURRENCE OF IODINATED X-RAY CONTRAST MEDIA IN DOMESTIC EFFLUENTS AND THEIR FATE DURING INDIRECT POTABLE REUSE , 2001, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[18]  J. Müller,et al.  Biodegradation of persistent polar pollutants in wastewater: comparison of an optimised lab-scale membrane bioreactor and activated sludge treatment. , 2006, Water research.

[19]  Víctor Matamoros,et al.  Organic micropollutant removal in a full-scale surface flow constructed wetland fed with secondary effluent. , 2008, Water research.

[20]  W J Peijnenburg,et al.  Evaluation and application of models for the prediction of ready biodegradability in the MITI-I test. , 1999, Chemosphere.

[21]  M. Banks,et al.  Biodegradation of Disodium Cocoamphodiacetate by a Wastewater Microbial Consortium , 2008, Water environment research : a research publication of the Water Environment Federation.

[22]  Oliver A.H. Jones,et al.  The occurrence and removal of selected pharmaceutical compounds in a sewage treatment works utilising activated sludge treatment. , 2007, Environmental pollution.

[23]  Adriano Joss,et al.  Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies. , 2007, The Science of the total environment.

[24]  Claudia Gallert,et al.  Elimination of COD, microorganisms and pharmaceuticals from sewage by trickling through sandy soil below leaking sewers. , 2003, Water research.

[25]  P. Bradley,et al.  Biotransformation of caffeine, cotinine, and nicotine in stream sediments: Implications for use as wastewater indicators , 2007, Environmental toxicology and chemistry.

[26]  Jun Li,et al.  Occurrence and elimination of antibiotics at four sewage treatment plants in the Pearl River Delta (PRD), South China. , 2007, Water research.

[27]  D. Grandjean,et al.  Fate and removal of polycyclic musks, UV filters and biocides during wastewater treatment. , 2006, Water research.

[28]  K. Kümmerer,et al.  Aerobic biodegradability of the calcium channel antagonist verapamil and identification of a microbial dead-end transformation product studied by LC-MS/MS. , 2008, Chemosphere.

[29]  N. Paxéus.  Removal of selected non-steroidal anti-inflammatory drugs (NSAIDs), gemfibrozil, carbamazepine, beta-blockers, trimethoprim and triclosan in conventional wastewater treatment plants in five EU countries and their discharge to the aquatic environment. , 2004, Water science and technology : a journal of the International Association on Water Pollution Research.

[30]  H Kroiss,et al.  Relevance of the sludge retention time (SRT) as design criteria for wastewater treatment plants for the removal of endocrine disruptors and pharmaceuticals from wastewater. , 2004, Water science and technology : a journal of the International Association on Water Pollution Research.

[31]  Jaeweon Cho,et al.  Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters. , 2007, Water research.

[32]  M. Servos,et al.  Behavior and occurrence of estrogens in municipal sewage treatment plants--I. Investigations in Germany, Canada and Brazil. , 1999, The Science of the total environment.

[33]  Alessandra Carucci,et al.  Biodegradability and Toxicity of Pharmaceuticals in Biological Wastewater Treatment Plants , 2006, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[34]  M. Jekel,et al.  Removal of bulk dissolved organic carbon (DOC) and trace organic compounds by bank filtration and artificial recharge. , 2005, Water research.

[35]  B. Katzung.  Basic and Clinical Pharmacology , 1982 .

[36]  M. Schlömann,et al.  Transformation of diclofenac by the indigenous microflora of river sediments and identification of a major intermediate. , 2007, Chemosphere.

[37]  T. Ternes,et al.  Polar drug residues in sewage and natural waters in the state of Rio de Janeiro, Brazil. , 1999, The Science of the total environment.

[38]  T. Tuhkanen,et al.  Occurrence of acidic pharmaceuticals in raw and treated sewages and in receiving waters. , 2005, Water research.

[39]  Jaume Puigagut,et al.  Behavior of selected priority organic pollutants in horizontal subsurface flow constructed wetlands: a preliminary screening. , 2007, Chemosphere.

[40]  Gerald T Ankley,et al.  Repeating history: pharmaceuticals in the environment. , 2007, Environmental science & technology.

[41]  E. Bouwer,et al.  Occurrence and biodegradability studies of selected pharmaceuticals and personal care products in sewage effluent , 2006 .

[42]  Thomas A. Ternes,et al.  Occurrence and behavior of X-ray contrast media in sewage facilities and the aquatic environment , 2000 .

[43]  T. Ternes.  Occurrence of drugs in German sewage treatment plants and rivers 1 Dedicated to Professor Dr. Klaus , 1998 .

[44]  Armin Hauk,et al.  Measurement of triclosan in wastewater treatment systems , 2002, Environmental toxicology and chemistry.

[45]  H. D. Stensel,et al.  Wastewater Engineering: Treatment and Reuse , 2002 .

[46]  Thorsten Reemtsma,et al.  Pathways and metabolites of microbial degradation of selected acidic pharmaceutical and their occurrence in municipal wastewater treated by a membrane bioreactor. , 2005, Water research.

[47]  R. Halden,et al.  Mass balance assessment of triclosan removal during conventional sewage treatment. , 2007, Chemosphere.

[48]  G Lyberatos,et al.  On the occasional biodegradation of pharmaceuticals in the activated sludge process: the example of the antibiotic sulfamethoxazole. , 2005, Journal of hazardous materials.

[49]  D. Aga,et al.  Enhanced biodegradation of iopromide and trimethoprim in nitrifying activated sludge. , 2006, Environmental science & technology.

[50]  T. Walley,et al.  Selective serotonin reuptake inhibitors. , 1992, BMJ.

[51]  E. Michael Thurman,et al.  Response to Comment on “Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999−2000: A National Reconnaissance” , 2002 .

[52]  Dragan Gamberger,et al.  Evaluation of artificial intelligence based models for chemical biodegradability prediction. , 2004, Molecules.

[53]  Marta Carballa,et al.  Calculation methods to perform mass balances of micropollutants in sewage treatment plants. application to pharmaceutical and personal care products (PPCPs). , 2007, Environmental science & technology.

[54]  T. Poiger,et al.  Occurrence and Environmental Behavior of the Chiral Pharmaceutical Drug Ibuprofen in Surface Waters and in Wastewater , 1999 .

[55]  A. Fernández-Alba,et al.  Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on the Mediterranean coast. , 2007, Chemosphere.

[56]  H. Kroiss,et al.  The solids retention time-a suitable design parameter to evaluate the capacity of wastewater treatment plants to remove micropollutants. , 2005, Water research.

[57]  Marta Carballa,et al.  Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant. , 2004, Water research.

[58]  Mira Petrovic,et al.  Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor , 2006, Analytical and bioanalytical chemistry.

[59]  S. Zuehlke,et al.  Behavior of two differently radiolabelled 17alpha-ethinylestradiols continuously applied to a laboratory-scale membrane bioreactor with adapted industrial activated sludge. , 2007, Water research.

[60]  T. Ternes,et al.  Behaviour and occurrence of estrogens in municipal sewage treatment plants--II. Aerobic batch experiments with activated sludge. , 1999, The Science of the total environment.

[61]  T. Ternes,et al.  Irrigation of treated wastewater in Braunschweig, Germany: an option to remove pharmaceuticals and musk fragrances. , 2007, Chemosphere.

[62]  E. Heath,et al.  Removal of pharmaceutical residues in a pilot wastewater treatment plant , 2007, Analytical and bioanalytical chemistry.

[63]  Deborah A. Grimm,et al.  Naproxen removal from water by chlorination and biofilm processes. , 2005, Water research.

[64]  J. Vader,et al.  Degradation of ethinyl estradiol by nitrifying activated sludge. , 2000, Chemosphere.

[65]  N Kreuzinger,et al.  Comparison of the behaviour of selected micropollutants in a membrane bioreactor and a conventional wastewater treatment plant. , 2004, Water science and technology : a journal of the International Association on Water Pollution Research.

[66]  J E Drewes,et al.  Fate of pharmaceuticals during indirect potable reuse. , 2002, Water science and technology : a journal of the International Association on Water Pollution Research.

[67]  Klaus Kümmerer,et al.  Biodegradability of 14C-labeled antibiotics in a modified laboratory scale sewage treatment plant at environmentally relevant concentrations. , 2006, Environmental science & technology.

[68]  T. Tuhkanen,et al.  Seasonal variation in the occurrence of pharmaceuticals in effluents from a sewage treatment plant and in the recipient water. , 2005, Environmental science & technology.

[69]  Max Maurer,et al.  Elimination of β-blockers in sewage treatment plants , 2007 .

[70]  Jon F Ericson,et al.  An evaluation of the OECD 308 water/sediment systems for investigating the biodegradation of pharmaceuticals. , 2007, Environmental science & technology.

[71]  D. Grandjean,et al.  Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment. , 2005, Water research.

[72]  Diana S Aga,et al.  Removal of antibiotics in wastewater: Effect of hydraulic and solid retention times on the fate of tetracycline in the activated sludge process. , 2005, Environmental science & technology.

[73]  R. Zytner,et al.  Removal of ibuprofen from wastewater: comparing biodegradation in conventional, membrane bioreactor, and biological nutrient removal treatment systems. , 2008, Water science and technology : a journal of the International Association on Water Pollution Research.

[74]  F. Frimmel,et al.  Short-term tests with a pilot sewage plant and biofilm reactors for the biological degradation of the pharmaceutical compounds clofibric acid, ibuprofen, and diclofenac. , 2003, The Science of the total environment.

[75]  Daniel Mamais,et al.  Investigation of triclosan fate and toxicity in continuous-flow activated sludge systems. , 2007, Chemosphere.

[76]  Watze de Wolf,et al.  Removal of fragrance materials during U.S. and European wastewater treatment. , 2002, Environmental science & technology.

[77]  A. Schäffer,et al.  Fate of a 14C-labeled nonylphenol isomer in a laboratory-scale membrane bioreactor. , 2006, Environmental science & technology.

[78]  S. Zuehlke,et al.  The impact of variable temperatures on the redox conditions and the behaviour of pharmaceutical residues during artificial recharge , 2006 .

[79]  D. Barceló,et al.  Biodegradation studies of selected priority acidic pesticides and diclofenac in different bioreactors. , 2006, Environmental pollution.

[80]  M. Winkler,et al.  Selective degradation of ibuprofen and clofibric acid in two model river biofilm systems. , 2001, Water research.

[81]  Amy M F Choong,et al.  A preliminary ecotoxicity study of pharmaceuticals in the marine environment. , 2006, Journal of toxicology and environmental health. Part A.

[82]  T. Tuhkanen,et al.  Elimination of pharmaceuticals in sewage treatment plants in Finland. , 2007, Water research.

[83]  W. Kalsch.  Biodegradation of the iodinated X-ray contrast media diatrizoate and iopromide. , 1999, The Science of the total environment.

[84]  A. Al-Ahmad,et al.  Biodegradability of the Anti‐tumour Agents 5‐Fluorouracil, Cytarabine, and Gemcitabine: Impact of the Chemical Structure and Synergistic Toxicity with Hospital Effluent , 1997 .

[85]  R. Cela,et al.  Determination of acidic drugs in sewage water by gas chromatography-mass spectrometry as tert.-butyldimethylsilyl derivatives. , 2003, Journal of chromatography. A.

[86]  S. McGrath,et al.  Low biodegradability of fluoxetine HCl, diazepam and their human metabolites in sewage sludge-amended soil , 2008 .

[87]  K. Kümmerer,et al.  Biodegradability of the X-ray contrast compound diatrizoic acid, identification of aerobic degradation products and effects against sewage sludge micro-organisms. , 2006, Chemosphere.

[88]  K. Thomasb,et al.  Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom , 2004 .

[89]  Robert S. Boethling,et al.  Predicting ready biodegradability in the Japanese ministry of international trade and industry test , 2000 .

[90]  Shane A. Snyder,et al.  Biological and Physical Attenuation of Endocrine Disruptors and Pharmaceuticals: Implications for Water Reuse , 2004 .

[91]  H Kroiss,et al.  Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants. , 2005, Water research.

[92]  H. Takada,et al.  Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment. , 2006, Water research.

[93]  T. Ginn,et al.  Occurrence and fate of pharmaceutically active compounds in the environment, a case study: Höje River in Sweden. , 2005, Journal of hazardous materials.

[94]  G. Sayler,et al.  Mineralization of Steroidal Hormones by Biosolids in Wastewater Treatment Systems in Tennessee U.S.A. , 2000 .

[95]  T. Vasskog,et al.  Selective serotonin reuptake inhibitors in sewage influents and effluents from Tromsø, Norway. , 2006, Journal of Chromatography A.

[96]  F. Omil,et al.  Removal of pharmaceutically active compounds in nitrifying-denitrifying plants. , 2005, Water science and technology : a journal of the International Association on Water Pollution Research.

[97]  R. Kookana,et al.  Biological degradation of triclocarban and triclosan in a soil under aerobic and anaerobic conditions and comparison with environmental fate modelling. , 2007, Environmental pollution.

[98]  M. Crane,et al.  Chronic aquatic environmental risks from exposure to human pharmaceuticals. , 2006, The Science of the total environment.

[99]  Bent Halling-Sørensen,et al.  Fate of estrogens in a municipal sewage treatment plant. , 2003, Environmental science & technology.

[100]  Roberta Curini,et al.  Monitoring Natural and Synthetic Estrogens at Activated Sludge Sewage Treatment Plants and in a Receiving River Water , 2000 .

[101]  Ken Li,et al.  A preliminary study on the occurrence and behavior of sulfonamides, ofloxacin and chloramphenicol antimicrobials in wastewaters of two sewage treatment plants in Guangzhou, China. , 2006, The Science of the total environment.

[102]  J. Bayona,et al.  Elimination of pharmaceuticals and personal care products in subsurface flow constructed wetlands. , 2006, Environmental science & technology.

[103]  M. Carballa,et al.  Comparison between the conventional anaerobic digestion of sewage sludge and its combination with a chemical or thermal pre-treatment concerning the removal of pharmaceuticals and personal care products. , 2006, Water science and technology : a journal of the International Association on Water Pollution Research.

[104]  Robert S Boethling,et al.  Using Biowin™, Bayes, and batteries to predict ready biodegradability , 2004, Environmental toxicology and chemistry.

[105]  Stanley Heckadon-Moreno.  LIGHT AND SHADOWS IN THE MANAGEMENT OF THE PANAMA CANAL WATERSHED , 2005 .

[106]  Adriano Joss,et al.  Removal of estrogens in municipal wastewater treatment under aerobic and anaerobic conditions: consequences for plant optimization. , 2004, Environmental science & technology.