Sex differences in response to lithium treatment.

OBJECTIVE Although sex differences occur with some psychotropic drug treatments, they are not well defined for mood-stabilizing agents, including lithium. The authors' goal was to investigate whether there are differences between the sexes in response to lithium. METHOD Studies identified in a literature search were analyzed for reports of sex differences in clinical response to lithium in major affective syndromes. RESULTS Data from 17 studies published in 1967-1998, involving 1,548 adults treated with lithium for a mean of 38.6 months (SD=30.5), yielded similar weighted response rates to lithium in 1,043 women (65.6% [N=684]) and 505 men (61.0% [N=308]). CONCLUSIONS The results indicate little difference between the sexes in clinical response to lithium treatment of bipolar and related affective disorders.

[1]  R. Baldessarini,et al.  Effects of rapid cycling on response to lithium maintenance treatment in 360 bipolar I and II disorder patients. , 2000, Journal of affective disorders.

[2]  E. Leibenluft.  Gender Differences in Major Depressive Disorder and Bipolar Disorder , 1999, CNS Spectrums.

[3]  R. M. Lusznat,et al.  Carbamazepine vs Lithium in the Treatment and Prophylaxis of Mania , 1988, British Journal of Psychiatry.

[4]  A. Coppen,et al.  Who responds to prophylactic lithium? , 1986, Journal of affective disorders.

[5]  P. W. Brooks,et al.  A controlled evaluation of lithium prophylaxis in affective disorders , 1972, Psychological Medicine.

[6]  P. Baastrup,et al.  Lithium As a Prophylactic Agent: Its Effect Against Recurrent Depressions and Manic-Depressive Psychosis , 1967 .

[7]  R. Baldessarini,et al.  Lithium maintenance treatment of depression and mania in bipolar I and bipolar II disorders. , 1998, The American journal of psychiatry.

[8]  F. Engelsmann,et al.  Predictors of Lithium Treatment Responsiveness in Bipolar Patients , 1998, Neuropsychobiology.

[9]  F. Goodwin.  Manic-Depressive Illness , 1990 .

[10]  D. March,et al.  Lithium During Pregnancy , 1998, CNS drugs.

[11]  P. Vestergaard,et al.  Predictors of outcome in prophylactic lithium treatment: a 2-year prospective study. , 1990, Journal of affective disorders.

[12]  Identifying lithium-responsive bipolar depressed patients using nuclear magnetic resonance. , 1986, The American journal of psychiatry.

[13]  J. Jefferson,et al.  A reevaluation of risk of in utero exposure to lithium. , 1994, JAMA.

[14]  A. Poole,et al.  Treatment Experiences in the Lithium Clinic at St Thomas’ Hospital 1 , 1978, Journal of the Royal Society of Medicine.

[15]  L. Magliano,et al.  Long-term outcome of lithium prophylaxis in bipolar disorder: a 5-year prospective study of 402 patients at a lithium clinic. , 1998, The American journal of psychiatry.

[16]  P. Melia.  Prophylactic Lithium: A Double-Blind Trial in Recurrent Affective Disorders , 1970, British Journal of Psychiatry.

[17]  K. Yonkers,et al.  Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication. , 1992, The American journal of psychiatry.

[18]  R. Fieve,et al.  Clinical factors in lithium carbonate prophylaxis failure. , 1974, Archives of general psychiatry.

[19]  P. Grof,et al.  Lithium Prophylaxis in Recurrent Affective Disorders , 1970, British Journal of Psychiatry.

[20]  K. Dawkins.  Gender Differences in Psychiatry , 1995 .

[21]  I. Leppik,et al.  Treatment of Epilepsy in Women of Childbearing Potential , 1999 .

[22]  R. Baldessarini,et al.  Rapid cycling in women and men with bipolar manic-depressive disorders. , 1998, The American journal of psychiatry.

[23]  M. Taylor,et al.  Prediction of treatment response in mania. , 1981, Archives of general psychiatry.

[24]  D. Murphy,et al.  Prediction of antidepressant responses to lithium. , 1978, The American journal of psychiatry.