Human Postural Control Under High Levels of Extremely Low Frequency Magnetic Fields

Background: International agencies such as the International Commission on Non-Ionizing Radiation Protection (ICNIRP) and the International Committee on Electromagnetic Safety (ICES) of the Institute of Electrical and Electronics Engineers (IEEE) need further data to set international guidelines to protect workers and the public from potential adverse effects to Extremely Low-Frequency Magnetic Fields (ELF-MF). Interestingly, electromagnetic induction has been hypothesized to impact human vestibular function (i.e. through induced electric fields). To date, a theoretical 4 T/s vestibular threshold was proposed to modulate postural control, but data is lacking above this limit. Objectives: This research aimed to investigate the impact of full head homogeneous ELF-MF stimulations above the 4 T/s threshold on human postural control. Methods: Postural control of twenty healthy participants was analyzed while full head homogeneous ELF-MF stimulations (20 Hz, 60 Hz, and 90 Hz) up to 40 T/s were applied. Velocity, main direction and spatial dispersion of sway were used to investigate postural modulations. Results: Despite a conclusive positive control effect, no significant effects of ELF-MF exposures on velocity, spatial dispersion, and direction of the postural sway were found for our 3 frequency conditions. Conclusions: The homogeneous full head MF stimulations oriented vertically and delivered at high frequencies induced E-fields having a weaker impact than anticipated, possibly because they impacted only a small portion of the vestibular system. This resulted in an absence of effect on postural control outcomes.

[1]  P. Å. Öberg,et al.  Magnetophosphenes: a quantitative analysis of thresholds , 1980, Medical and Biological Engineering and Computing.

[2]  J. Nadal,et al.  Calculation of area of stabilometric signals using principal component analysis , 1996, Physiological measurement.

[3]  D. Drost,et al.  Human subjects exposed to a specific pulsed (200 μT) magnetic field: effects on normal standing balance , 2001, Neuroscience Letters.

[4]  Ian S. Curthoys,et al.  Otolithic Receptor Mechanisms for Vestibular-Evoked Myogenic Potentials: A Review , 2018, Front. Neurol..

[5]  Dale C. Roberts,et al.  MRI Magnetic Field Stimulates Rotational Sensors of the Brain , 2011, Current Biology.

[6]  Leon Lagnado,et al.  Continuous Vesicle Cycling in the Synaptic Terminal of Retinal Bipolar Cells , 1996, Neuron.

[7]  E. Glowatzki,et al.  Glutamatergic Signaling at the Vestibular Hair Cell Calyx Synapse , 2014, The Journal of Neuroscience.

[8]  B. Day,et al.  Short-latency eye movements evoked by near-threshold galvanic vestibular stimulation , 2003, Experimental Brain Research.

[9]  Omar S Mian,et al.  Violation of the Craniocentricity Principle for Vestibularly Evoked Balance Responses under Conditions of Anisotropic Stability , 2014, The Journal of Neuroscience.

[10]  I. Curthoys,et al.  The new vestibular stimuli: sound and vibration—anatomical, physiological and clinical evidence , 2017, Experimental Brain Research.

[11]  F S Prato,et al.  Human standing balance is affected by exposure to pulsed ELF magnetic fields: light intensity-dependent effects , 2001, Neuroreport.

[12]  J. P. Reilly,et al.  Magnetic field excitation of peripheral nerves and the heart: a comparison of thresholds , 1991, Medical and Biological Engineering and Computing.

[13]  J. Birchall,et al.  Comparison of body sway analysis techniques. Assessment with subjects standing on a stable surface. , 1994, Acta oto-laryngologica.

[14]  R. Bowtell,et al.  Magnetic‐field‐induced vertigo: A theoretical and experimental investigation , 2007, Bioelectromagnetics.

[15]  Vassilia Hatzitaki,et al.  Postural and muscle responses to galvanic vestibular stimulation reveal a vestibular deficit in adolescents with idiopathic scoliosis , 2019, The European journal of neuroscience.

[16]  M. Bikson,et al.  Role of cortical cell type and morphology in subthreshold and suprathreshold uniform electric field stimulation in vitro , 2009, Brain Stimulation.

[17]  Andrew A. Marino,et al.  Frequency-specific blocking in the human brain caused by electromagnetic fields. , 1994, Neuroreport.

[18]  Jorge M. Serrador,et al.  Head position modifies cerebrovascular response to orthostatic stress , 2003, Brain Research.

[19]  Marek Zmyślony,et al.  Neurovegetative disturbances in workers exposed to 50 Hz electromagnetic fields. , 2006, International journal of occupational medicine and environmental health.

[20]  Philipp Berens,et al.  CircStat: AMATLABToolbox for Circular Statistics , 2009, Journal of Statistical Software.

[21]  A Straube,et al.  Visual stabilization of posture. Physiological stimulus characteristics and clinical aspects. , 1984, Brain : a journal of neurology.

[22]  Paola Perin,et al.  Mechanisms and effects of transepithelial polarization in the isolated semicircular canal , 1998, Hearing Research.

[23]  Patrik Raudaschl,et al.  Analysis of Vestibular Labyrinthine Geometry and Variation in the Human Temporal Bone , 2018, Front. Neurosci..

[24]  Akimasa Hirata,et al.  Synopsis of IEEE Std C95.1™-2019 “IEEE Standard for Safety Levels With Respect to Human Exposure to Electric, Magnetic, and Electromagnetic Fields, 0 Hz to 300 GHz” , 2019, IEEE Access.

[25]  H. Wässle,et al.  Glutamate Receptors in the Rod Pathway of the Mammalian Retina , 2001, The Journal of Neuroscience.

[26]  H P Zenner,et al.  Electrically evoked motile responses of mammalian type I vestibular hair cells. , 1992, Journal of vestibular research : equilibrium & orientation.

[27]  G Michael Halmagyi,et al.  Latency and initiation of the human vestibuloocular reflex to pulsed galvanic stimulation. , 2006, Journal of neurophysiology.

[28]  Oliver Kraff,et al.  Vestibular Effects of a 7 Tesla MRI Examination Compared to 1.5 T and 0 T in Healthy Volunteers , 2014, PloS one.

[29]  Mohsen Jamali,et al.  Integration of Canal and Otolith Inputs by Central Vestibular Neurons Is Subadditive for Both Active and Passive Self-Motion: Implication for Perception , 2015, The Journal of Neuroscience.

[30]  David G Besselsen,et al.  Practical aspects of experimental design in animal research. , 2002, ILAR journal.

[31]  Gergely Nagymáté,et al.  Reliability analysis of a sensitive and independent stabilometry parameter set , 2018, PloS one.

[32]  Ian S. Curthoys,et al.  The Skull Vibration-Induced Nystagmus Test of Vestibular Function—A Review , 2017, Front. Neurol..

[33]  D. Drost,et al.  A comparison of rheumatoid arthritis and fibromyalgia patients and healthy controls exposed to a pulsed (200 μT) magnetic field: effects on normal standing balance , 2001, Neuroscience Letters.

[34]  Zbisław Tabor,et al.  Influence of 50 Hz magnetic field on human heart rate variablilty: Linear and nonlinear analysis , 2004, Bioelectromagnetics.

[35]  Luca Bonfiglio,et al.  Effects of 50Hz electromagnetic fields on electroencephalographic alpha activity, dental pain threshold and cardiovascular parameters in humans , 2005, Neuroscience Letters.

[36]  Akimasa Hirata,et al.  Computational analysis shows why transcranial alternating current stimulation induces retinal phosphenes , 2013, Journal of neural engineering.

[37]  B L Day,et al.  Magnetic field effects on the vestibular system: calculation of the pressure on the cupula due to ionic current-induced Lorentz force , 2012, Physics in medicine and biology.

[38]  M. Todd,et al.  Gentamicin vestibulotoxicity impairs human electrically evoked vestibulo-ocular reflex , 2008, Neurology.

[39]  Brian L Day,et al.  Probing the human vestibular system with galvanic stimulation. , 2004, Journal of applied physiology.

[40]  Per Lövsund,et al.  Quantitative determination of thresholds of magnetophosphenes , 1979 .

[41]  Callum J. Osler,et al.  Galvanic Vestibular Stimulation Produces Sensations of Rotation Consistent with Activation of Semicircular Canal Afferents , 2012, Front. Neur..

[42]  D S Kim,et al.  Influence of exposure to electromagnetic field on the cardiovascular system. , 2005, Autonomic & autacoid pharmacology.

[43]  Andrew A. Marino,et al.  Alterations in brain electrical activity caused by magnetic fields: detecting the detection process. , 1992, Electroencephalography and clinical neurophysiology.

[44]  Maurice Ouaknine,et al.  Body response to binaural monopolar galvanic vestibular stimulation in humans , 1998, Neuroscience Letters.

[45]  Angelo Cappello,et al.  Stabilometric parameters are affected by anthropometry and foot placement. , 2002, Clinical biomechanics.

[46]  Julia Dlugaiczyk,et al.  Galvanic vestibular stimulation: from basic concepts to clinical applications. , 2019, Journal of neurophysiology.

[47]  Omar S Mian,et al.  A dynamic model of the eye nystagmus response to high magnetic fields , 2014, Physics in medicine and biology.

[48]  John G R Jefferys,et al.  A NEUROBIOLOGICAL BASIS FOR ELF GUIDELINES , 2007, Health physics.

[49]  H. Straka,et al.  Galvanic Vestibular Stimulation: Cellular Substrates and Response Patterns of Neurons in the Vestibulo-Ocular Network , 2016, The Journal of Neuroscience.

[50]  P A Oberg,et al.  Influence on vision of extremely low frequence electromagnetic fields. Industrial measurements, magnetophosphene studies volunteers and intraretinal studies in animals. , 1979, Acta ophthalmologica.

[51]  Stuart W. Mackenzie,et al.  Ocular torsion responses to sinusoidal electrical vestibular stimulation , 2018, Journal of Neuroscience Methods.

[52]  A. S. French,et al.  Information processing by graded-potential transmission through tonically active synapses , 1996, Trends in Neurosciences.

[53]  David S Zee,et al.  Vestibular stimulation by magnetic fields , 2015, Annals of the New York Academy of Sciences.

[54]  J. Songer,et al.  Vestibular hair cells and afferents: two channels for head motion signals. , 2011, Annual review of neuroscience.

[55]  A. Beuter,et al.  Neurophysiological and behavioral effects of a 60 Hz, 1,800 μT magnetic field in humans , 2012, European Journal of Applied Physiology.

[56]  K. Jokela,et al.  ICNIRP Guidelines GUIDELINES FOR LIMITING EXPOSURE TO TIME-VARYING , 1998 .

[57]  M Bikson,et al.  Effects of weak electric fields on the activity of neurons and neuronal networks. , 2003, Radiation protection dosimetry.

[58]  Akimasa Hirata,et al.  An electric field induced in the retina and brain at threshold magnetic flux density causing magnetophosphenes , 2011, Physics in medicine and biology.

[59]  J. Iles,et al.  Simple models of stimulation of neurones in the brain by electric fields. , 2005, Progress in biophysics and molecular biology.

[60]  Selcuk Comlekci,et al.  Influence of 50 Hz-1 mT magnetic field on human median nerve , 2012, Electromagnetic biology and medicine.

[61]  Gunter P. Siegmund,et al.  Electrical Vestibular Stimuli Evoke Robust Muscle Activity in Deep and Superficial Neck Muscles in Humans , 2018, Front. Neurol..

[62]  A. Cappello,et al.  Feature selection of stabilometric parameters based on principal component analysis , 2006, Medical and Biological Engineering and Computing.

[63]  N. Isu,et al.  Cross‐Striolar and Commissural Inhibition in the Otolith System , 1999, Annals of the New York Academy of Sciences.

[64]  D. Attwell,et al.  Interaction of low frequency electric fields with the nervous system: the retina as a model system. , 2003, Radiation protection dosimetry.

[65]  P. Å. Öberg,et al.  Magneto- and electrophosphenes: A comparative study , 1980, Medical and Biological Engineering and Computing.

[66]  H D Cohen,et al.  Dose response study of human exposure to 60 Hz electric and magnetic fields. , 1994, Bioelectromagnetics.

[67]  Hans Kromhout,et al.  Exposure to MRI-related magnetic fields and vertigo in MRI workers , 2015, Occupational and Environmental Medicine.

[68]  William H Warren,et al.  A new measure of the CoP trajectory in postural sway: dynamics of heading change. , 2014, Medical engineering & physics.

[69]  Paul Glover,et al.  Magnetic Field-Induced Vertigo in the MRI Environment , 2015, Current Radiology Reports.