Decrease of the vessel wall anti-aggregating activity in aged rabbits

Incidence of vascular diseases increases with age and it is known that a biological cooperation occurs between platelets and the vessel wall. This interaction could play a role in the pathogenesis of vascular diseases.Platelet-vessel wall interactions were explored in young (1 year) and old (>4 years) rabbits. Platelet-rich plasma (PRP) aggregation in response to collagen did not differ comparing old and young rabbits. In contrast, PRP aggregation after perfusion of autologous isolated aortas was significantly reduced in young rabbits while no anti-aggregatory activity could be observed in perfused PRP from old rabbits. This difference is unlikely to be due to platelets, but may rather relate to a reduced capacity of the vascular wall to produce factors such as prostacyclin and EDRF (endothelium-derived relaxing factor).

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