Cost-effectiveness of guided self-help treatment for recurrent binge eating.

OBJECTIVE Adoption of effective treatments for recurrent binge-eating disorders depends on the balance of costs and benefits. Using data from a recent randomized controlled trial, we conducted an incremental cost-effectiveness analysis (CEA) of a cognitive-behavioral therapy guided self-help intervention (CBT-GSH) to treat recurrent binge eating compared to treatment as usual (TAU). METHOD Participants were 123 adult members of an HMO (mean age = 37.2 years, 91.9% female, 96.7% non-Hispanic White) who met criteria for eating disorders involving binge eating as measured by the Eating Disorder Examination (C. G. Fairburn & Z. Cooper, 1993). Participants were randomized either to treatment as usual (TAU) or to TAU plus CBT-GSH. The clinical outcomes were binge-free days and quality-adjusted life years (QALYs); total societal cost was estimated using costs to patients and the health plan and related costs. RESULTS Compared to those receiving TAU only, those who received TAU plus CBT-GSH experienced 25.2 more binge-free days and had lower total societal costs of $427 over 12 months following the intervention (incremental CEA ratio of -$20.23 per binge-free day or -$26,847 per QALY). Lower costs in the TAU plus CBT-GSH group were due to reduced use of TAU services in that group, resulting in lower net costs for the TAU plus CBT group despite the additional cost of CBT-GSH. CONCLUSIONS Findings support CBT-GSH dissemination for recurrent binge-eating treatment.

[1]  M A Koopmanschap,et al.  Towards a new approach for estimating indirect costs of disease. , 1992, Social science & medicine.

[2]  H. Kraemer,et al.  Recruitment for a guided self-help binge eating trial: potential lessons for implementing programs in everyday practice settings. , 2009, Contemporary clinical trials.

[3]  L. George,et al.  Depression, disability days, and days lost from work in a prospective epidemiologic survey. , 1990, JAMA.

[4]  S. Pilling,et al.  The health service use and cost of eating disorders , 2005, Psychological Medicine.

[5]  M. Hornbrook,et al.  Assessing relative health plan risk with the RAND-36 health survey. , 1995, Inquiry : a journal of medical care organization, provision and financing.

[6]  M J Al,et al.  Costs, effects and C/E-ratios alongside a clinical trial. , 1994, Health economics.

[7]  R. Masheb,et al.  Quality of life in patients with binge eating disorder , 2004, Eating and weight disorders : EWD.

[8]  C. Fairburn Cognitive Behavior Therapy and Eating Disorders , 2008 .

[9]  S. Crow,et al.  Utilization of empirically supported psychotherapy treatments for individuals with eating disorders: A survey of psychologists. , 2000, The International journal of eating disorders.

[10]  R. Kessler,et al.  The Prevalence and Correlates of Eating Disorders in the National Comorbidity Survey Replication , 2007, Biological Psychiatry.

[11]  M. Mcgrath Cost Effectiveness in Health and Medicine. , 1998 .

[12]  S. Saxena,et al.  Dollars, DALYs and Decisions: Economic Aspects of the Mental Health System , 2006 .

[13]  Jacob Cohen Statistical Power Analysis for the Behavioral Sciences , 1969, The SAGE Encyclopedia of Research Design.

[14]  Nancy D Berkman,et al.  Binge eating disorder treatment: a systematic review of randomized controlled trials. , 2007, The International journal of eating disorders.

[15]  T. Silber,et al.  Hospitalization of children and adolescents for eating disorders in the State of New York. , 2006, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[16]  R. Rosenheck,et al.  One-year use and cost of inpatient and outpatient services among female and male patients with an eating disorder: evidence from a national database of health insurance claims. , 2000, The International journal of eating disorders.

[17]  G. Noordenbos,et al.  Quality of life and eating disorders , 2005, Quality of Life Research.

[18]  W. Katon,et al.  Cost-effectiveness of a collaborative care program for primary care patients with persistent depression. , 2001, The American journal of psychiatry.

[19]  D. Chisholm,et al.  Effectiveness and cost-effectiveness of policies and programmes to reduce the harm caused by alcohol , 2009, The Lancet.

[20]  S. Brophy,et al.  Interventions for latent autoimmune diabetes (LADA) in adults. , 2011, The Cochrane database of systematic reviews.

[21]  Janet Treasure,et al.  A randomized controlled trial of family therapy and cognitive behavior therapy guided self-care for adolescents with bulimia nervosa and related disorders. , 2009, The American journal of psychiatry.

[22]  G. Zarkin,et al.  Economic Evaluation of Alcoholism Treatment , 2006, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.

[23]  E. Fombonne,et al.  The Maudsley long-term follow-up of child and adolescent depression , 2001, British Journal of Psychiatry.

[24]  Michael J. Goodman,et al.  Chronic disease, functional health status, and demographics: a multi-dimensional approach to risk adjustment. , 1996, Health services research.

[25]  J. Lave,et al.  Cost-effectiveness of treatments for major depression in primary care practice. , 1998, Archives of general psychiatry.

[26]  Russell V. Lenth,et al.  Statistical Analysis With Missing Data (2nd ed.) (Book) , 2004 .

[27]  C. Fairburn,et al.  Overcoming binge eating. , 1995 .

[28]  C. Las Hayas,et al.  Health-Related Quality of Life for Eating Disorders questionnaire version-2 was responsive 1-year after initial assessment. , 2007, Journal of clinical epidemiology.

[29]  A. Briggs,et al.  Something old, something new, something borrowed, something blue: a framework for the marriage of health econometrics and cost-effectiveness analysis. , 2002, Health economics.

[30]  J. Krupnick Psychological Treatments of Binge Eating Disorder , 2011 .

[31]  H. Kraemer,et al.  Screening for binge eating disorders using the Patient Health Questionnaire in a community sample. , 2009, The International journal of eating disorders.

[32]  A A Stinnett,et al.  Net Health Benefits , 1998, Medical decision making : an international journal of the Society for Medical Decision Making.

[33]  M. French Economic evaluation of alcohol treatment services. , 2000, Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism.

[34]  M. Hornbrook,et al.  Assessing health plan case mix in employed populations: ambulatory morbidity and prescribed drug models. , 1991, Advances in health economics and health services research.

[35]  C. Fairburn,et al.  Eating Disorder Examination Questionnaire , 2011 .

[36]  P. Dolan Developing methods that really do value the ‘Q’ in the QALY , 2008, Health Economics, Policy and Law.

[37]  S. Wessely,et al.  Chronic fatigue in general practice: economic evaluation of counselling versus cognitive behaviour therapy. , 2001, The British journal of general practice : the journal of the Royal College of General Practitioners.

[38]  C. Sherbourne,et al.  Cost-effectiveness of practice-initiated quality improvement for depression: results of a randomized controlled trial. , 2001, JAMA.

[39]  John Brazier,et al.  Measuring and valuing mental health for use in economic evaluation , 2008, Journal of health services research & policy.

[40]  H. Hoek,et al.  Review of the prevalence and incidence of eating disorders. , 2003, The International journal of eating disorders.

[41]  P. Lachenbruch Statistical Power Analysis for the Behavioral Sciences (2nd ed.) , 1989 .

[42]  F. Lynch,et al.  Cost-effectiveness of a tailored intervention to increase screening in HMO women overdue for Pap test and mammography services. , 2004, Preventive medicine.

[43]  P. Hay,et al.  Psychotherapy for bulimia nervosa and binging. , 2001, The Cochrane database of systematic reviews.

[44]  S. Palmer,et al.  The cost-effectiveness of cognitive behavior therapy for borderline personality disorder: results from the BOSCOT trial. , 2006, Journal of personality disorders.

[45]  J. Powell,et al.  A randomized effectiveness trial of brief cognitive-behavioral therapy for depressed adolescents receiving antidepressant medication. , 2005, Journal of the American Academy of Child and Adolescent Psychiatry.

[46]  S. Thompson,et al.  How should cost data in pragmatic randomised trials be analysed? , 2000, BMJ : British Medical Journal.

[47]  R. Sysko,et al.  Frequency of binge eating episodes in bulimia nervosa and binge eating disorder: Diagnostic considerations. , 2009, The International journal of eating disorders.

[48]  G. Wilson,et al.  Psychological treatment of eating disorders. , 2007, The American psychologist.

[49]  David A. Chambers,et al.  Implementation Research in Mental Health Services: an Emerging Science with Conceptual, Methodological, and Training challenges , 2008, Administration and Policy in Mental Health and Mental Health Services Research.

[50]  P. Hay,et al.  Functional impairment associated with bulimic behaviors in a community sample of men and women. , 2007, The International journal of eating disorders.

[51]  H. Doll,et al.  Eating disorders and emotional and physical well-being: Associations between student self-reports of eating disorders and quality of life as measured by the SF-36 , 2005, Quality of Life Research.

[52]  C. Fairburn,et al.  The Eating Disorder Examination (12th edition). , 1993 .

[53]  C. Grilo,et al.  A randomized controlled comparison of guided self-help cognitive behavioral therapy and behavioral weight loss for binge eating disorder. , 2005, Behaviour research and therapy.

[54]  B J O'Brien,et al.  Analysis of uncertainty in health care cost-effectiveness studies: an introduction to statistical issues and methods , 2002, Statistical methods in medical research.

[55]  Patrick Royston,et al.  Multiple Imputation of Missing Values: Update , 2005 .

[56]  W. Katon,et al.  Recovery from depression, work productivity, and health care costs among primary care patients. , 2000, General hospital psychiatry.

[57]  Pamela T. Fishel-Ingram Cost-Outcome Methods for Mental Health , 2000 .

[58]  M. Galanter,et al.  Recent Developments in Alcoholism , 2012 .

[59]  D. Rubin,et al.  Statistical Analysis with Missing Data. , 1989 .

[60]  H. Kraemer,et al.  Gender difference in the prevalence of eating disorder symptoms. , 2009, The International journal of eating disorders.

[61]  E. Fombonne,et al.  The Maudsley long-term follow-up of child and adolescent depression , 2002, British Journal of Psychiatry.

[62]  W. Agras The consequences and costs of the eating disorders. , 2001, The Psychiatric clinics of North America.

[63]  Supon Limwattananon,et al.  The Equity Impact of the Universal Coverage Policy: Lessons from Thailand , 2009, Advances in health economics and health services research.

[64]  T. Vos,et al.  The burden of mental disorders: a comparison of methods between the Australian burden of disease studies and the Global Burden of Disease study. , 2000, Bulletin of the World Health Organization.

[65]  Jürgen Unützer,et al.  Cost-Effectiveness of a Program to Prevent Depression Relapse in Primary Care , 2002, Medical care.

[66]  C. Roberts,et al.  Economic evaluation of a randomised controlled trial for anorexia nervosa in adolescents , 2007, British Journal of Psychiatry.

[67]  Gouke J. Bonsel,et al.  Disability Weights for Diseases: A Modified Protocol and Results for a Western European Region , 2000 .

[68]  M. Knapp,et al.  “The trouble with QALYs…” , 2007, Epidemiology and Psychiatric Sciences.

[69]  E. Proctor,et al.  Implementation Research in Mental Health Services , 2009 .

[70]  P. Thuras,et al.  A survey of binge eating and obesity treatment practices among primary care providers. , 2004, The International journal of eating disorders.

[71]  E. Ziegel,et al.  Bootstrapping: A Nonparametric Approach to Statistical Inference , 1993 .

[72]  Angela M. Simmons,et al.  Factors Influencing the Utilization of Empirically Supported Treatments for Eating Disorders , 2008, Eating disorders.

[73]  R. Striegel-Moore,et al.  Help seeking and barriers to treatment in a community sample of Mexican American and European American women with eating disorders. , 2006, The International journal of eating disorders.

[74]  P. Hay,et al.  Perceptions of Cognitive Behavioural Guided Self-Help Treatment for Bulimia Nervosa in Primary Care , 2007, Eating disorders.

[75]  C. Grilo Eating and Weight Disorders , 2006 .

[76]  N. Perrin,et al.  Cost-effectiveness of an intervention to prevent depression in at-risk teens. , 2005, Archives of general psychiatry.

[77]  S. Crow,et al.  Monetary costs associated with bulimia. , 2009, The International journal of eating disorders.

[78]  B. Burns,et al.  Cost-effectiveness of treatments for adolescent depression: results from TADS. , 2008, The American journal of psychiatry.

[79]  Elisabeth Fenwick,et al.  A guide to cost-effectiveness acceptability curves. , 2005, The British journal of psychiatry : the journal of mental science.