Neuronal non-CG methylation is an essential target for MeCP2 function

[1]  H. Zoghbi,et al.  Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome , 2020, eLife.

[2]  A. Bird,et al.  The Molecular Basis of MeCP2 Function in the Brain. , 2020, Journal of molecular biology.

[3]  B. Waclaw,et al.  Absence of MeCP2 binding to non-methylated GT-rich sequences in vivo , 2020, Nucleic acids research.

[4]  A. Bird The Selfishness of Law-Abiding Genes. , 2020, Trends in genetics : TIG.

[5]  Eric C. Griffith,et al.  MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes. , 2019, Molecular cell.

[6]  M. Mann,et al.  Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly , 2019, bioRxiv.

[7]  K. Bui,et al.  The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications , 2019, bioRxiv.

[8]  B. Waclaw,et al.  Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic , 2019, Proceedings of the National Academy of Sciences.

[9]  R. Tjian,et al.  MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions , 2019, bioRxiv.

[10]  J. Min,et al.  Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain , 2019, bioRxiv.

[11]  Eric C. Griffith,et al.  Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing , 2018, Nature Neuroscience.

[12]  A. Bird,et al.  A mutation-led search for novel functional domains in MeCP2 , 2018, bioRxiv.

[13]  T. Hughes,et al.  Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA , 2018, The Journal of Biological Chemistry.

[14]  Harrison W. Gabel,et al.  Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States , 2017, Cell.

[15]  Robert J. Schmitz,et al.  Specifications of Targeting Heterochromatin Modifications in Plants. , 2017, Molecular plant.

[16]  A. Bird,et al.  Radically truncated MeCP2 rescues Rett syndrome-like neurological defects , 2017, Nature.

[17]  N. Heintz,et al.  5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes , 2017, Proceedings of the National Academy of Sciences.

[18]  J. Christodoulou,et al.  RettBASE: Rett syndrome database update , 2017, Human mutation.

[19]  P. Burbach,et al.  A current view on contactin-4, -5, and -6: Implications in neurodevelopmental disorders , 2017, Molecular and Cellular Neuroscience.

[20]  Leander M. Sinanan,et al.  Structural Basis of MeCP2 Distribution on Non-CpG Methylated and Hydroxymethylated DNA. , 2017, Journal of molecular biology.

[21]  A. Bird,et al.  MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain , 2017, PLoS genetics.

[22]  A. Bird,et al.  Structure of the MeCP2–TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders , 2017, Proceedings of the National Academy of Sciences.

[23]  Jin Billy Li,et al.  Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing , 2017, PLoS genetics.

[24]  Harrison W. Gabel,et al.  DNA methylation in the gene body influences MeCP2-mediated gene repression , 2016, Proceedings of the National Academy of Sciences.

[25]  I. Hellmann,et al.  Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise , 2016, Nucleic acids research.

[26]  A. Bird,et al.  Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes , 2016, Human molecular genetics.

[27]  A. Bird,et al.  The molecular basis of variable phenotypic severity among common missense mutations causing Rett syndrome , 2015, Human molecular genetics.

[28]  J. Ecker,et al.  Non-CG Methylation in the Human Genome. , 2015, Annual review of genomics and human genetics.

[29]  Terrence J. Sejnowski,et al.  Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain , 2015, Neuron.

[30]  Wei Li,et al.  MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome , 2015, Proceedings of the National Academy of Sciences.

[31]  Harrison W. Gabel,et al.  Disruption of DNA methylation-dependent long gene repression in Rett syndrome , 2015, Nature.

[32]  G. Drummen,et al.  Fluorescence Recovery After Photobleaching (FRAP) , 2014 .

[33]  D. Reinberg,et al.  AUTS2 confers gene activation to Polycomb group proteins in the CNS , 2014, Nature.

[34]  Björn Usadel,et al.  Trimmomatic: a flexible trimmer for Illumina sequence data , 2014, Bioinform..

[35]  W. Kaufmann,et al.  Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with disease severity in Rett syndrome , 2014, Journal of Medical Genetics.

[36]  P. Cui,et al.  Dynamic regulation of genome-wide pre-mRNA splicing and stress tolerance by the Sm-like protein LSm5 in Arabidopsis , 2014, Genome Biology.

[37]  Guoping Fan,et al.  Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain , 2013, Nature Neuroscience.

[38]  David A. Orlando,et al.  Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. , 2013, Cell stem cell.

[39]  Matthew D. Schultz,et al.  Global Epigenomic Reconfiguration During Mammalian Brain Development , 2013, Science.

[40]  A. Bird,et al.  Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor , 2013, Nature Neuroscience.

[41]  Wei Shi,et al.  featureCounts: an efficient general purpose program for assigning sequence reads to genomic features , 2013, Bioinform..

[42]  Timothy E. Reddy,et al.  Dynamic DNA methylation across diverse human cell lines and tissues , 2013, Genome research.

[43]  Le Cong,et al.  Multiplex Genome Engineering Using CRISPR/Cas Systems , 2013, Science.

[44]  N. Heintz,et al.  MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system , 2012, Epigenetics & Chromatin.

[45]  A. Bird,et al.  Disease Modeling Using Embryonic Stem Cells: MeCP2 Regulates Nuclear Size and RNA Synthesis in Neurons , 2012, Stem cells.

[46]  A. Bird,et al.  Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows. , 2012, Human molecular genetics.

[47]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[48]  B. Ren,et al.  Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome , 2012, Cell.

[49]  Michael E. Greenberg,et al.  Rett Syndrome Mutation MeCP2 T158A Disrupts DNA Binding, Protein Stability and ERP Responses , 2011, Nature Neuroscience.

[50]  A. Bird,et al.  CpG islands and the regulation of transcription. , 2011, Genes & development.

[51]  David C. Williams,et al.  Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence , 2011, Nucleic acids research.

[52]  Brian D. Marsden,et al.  High-throughput production of human proteins for crystallization: The SGC experience , 2010, Journal of structural biology.

[53]  Tatiana Nikitina,et al.  MeCP2 Binds Cooperatively to Its Substrate and Competes with Histone H1 for Chromatin Binding Sites , 2010, Molecular and Cellular Biology.

[54]  Robert S. Illingworth,et al.  Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state. , 2010, Molecular cell.

[55]  A. Bird,et al.  A Temporal Threshold for Formaldehyde Crosslinking and Fixation , 2009, PloS one.

[56]  Rodney C. Samaco,et al.  A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. , 2008, Human molecular genetics.

[57]  Stephen T. C. Wong,et al.  MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription , 2008, Science.

[58]  A. Bird,et al.  MeCP2 binding to DNA depends upon hydration at methyl-CpG. , 2008, Molecular cell.

[59]  R. Jaenisch,et al.  Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

[60]  W. Reik Stability and flexibility of epigenetic gene regulation in mammalian development , 2007, Nature.

[61]  A. Bird,et al.  Reversal of Neurological Defects in a Mouse Model of Rett Syndrome , 2007, Science.

[62]  A. Trumpp,et al.  Nestin‐Cre transgenic mouse line Nes‐Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite‐derived tissues , 2006, Genesis.

[63]  S. Nelson,et al.  The Disease Progression of Mecp2 Mutant Mice Is Affected by the Level of BDNF Expression , 2006, Neuron.

[64]  A. Bird,et al.  DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG. , 2005, Molecular cell.

[65]  J. Gécz,et al.  Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males. , 2005, American journal of human genetics.

[66]  Hua Chang,et al.  Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system , 2005, Journal of neuroscience research.

[67]  H. Zoghbi,et al.  Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. , 2004, Human molecular genetics.

[68]  M. Nakao,et al.  Heterogeneity in residual function of MeCP2 carrying missense mutations in the methyl CpG binding domain , 2003, Journal of medical genetics.

[69]  S. Tweedie,et al.  The methyl-CpG binding domain and the evolving role of DNA methylation in animals. , 2003, Trends in genetics : TIG.

[70]  E. Ballestar,et al.  Effects of Rett syndrome mutations of the methyl-CpG binding domain of the transcriptional repressor MeCP2 on selectivity for association with methylated DNA. , 2000, Biochemistry.

[71]  A. Bird,et al.  Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[72]  A. Bird,et al.  Vestiges of a DNA methylation system in Drosophila melanogaster? , 1999, Nature Genetics.

[73]  H. Zoghbi,et al.  Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 , 1999, Nature Genetics.

[74]  Colin A. Johnson,et al.  Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex , 1998, Nature.

[75]  A. Bird,et al.  MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin , 1997, Cell.

[76]  A. Bird,et al.  DNA methylation specifies chromosomal localization of MeCP2 , 1996, Molecular and cellular biology.

[77]  A. Bird,et al.  Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. , 1993, Nucleic acids research.

[78]  A. Bird,et al.  Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA , 1992, Cell.

[79]  Donald Macleod,et al.  A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA , 1985, Cell.

[80]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[81]  A. Bird,et al.  A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome , 2001, Nature Genetics.

[82]  K. Rajewsky,et al.  A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. , 1995, Nucleic acids research.

[83]  A. Bird,et al.  Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins , 2022 .