Synthetic Lung Nodule 3D Image Generation Using Autoencoders

One of the challenges of using machine learning techniques with medical data is the frequent dearth of source image data on which to train. A representative example is automated lung cancer diagnosis, where nodule images need to be classified as suspicious or benign. In this work we propose an automatic synthetic lung nodule image generator. Our 3D shape generator is designed to augment the variety of 3D images. Our proposed system takes root in autoencoder techniques, and we provide extensive experimental characterization that demonstrates its ability to produce quality synthetic images.

[1]  Zhangyang Wang,et al.  Deep Learning through Sparse and Low-Rank Modeling , 2019 .

[2]  Ulas Bagci,et al.  How to fool radiologists with generative adversarial networks? A visual turing test for lung cancer diagnosis , 2017, 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018).

[3]  Christopher C. Cummins,et al.  Synthesizing benchmarks for predictive modeling , 2017, 2017 IEEE/ACM International Symposium on Code Generation and Optimization (CGO).

[4]  P. Mahalanobis On the generalized distance in statistics , 1936 .

[5]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.

[6]  Jinbo Bi,et al.  Lung Nodule Detection , 2010, ImageCLEF.

[7]  Sridhar Mahadevan,et al.  Generative Multi-Adversarial Networks , 2016, ICLR.

[8]  K. Doi,et al.  Computerized detection of lung nodules in thin-section CT images by use of selective enhancement filters and an automated rule-based classifier. , 2008, Academic Radiology.

[9]  Simon Haykin,et al.  Neural Networks and Learning Machines , 2010 .

[10]  Geoffrey E. Hinton,et al.  Reducing the Dimensionality of Data with Neural Networks , 2006, Science.

[11]  Ole Winther,et al.  Autoencoding beyond pixels using a learned similarity metric , 2015, ICML.

[12]  Leonidas J. Guibas,et al.  GRASS: Generative Recursive Autoencoders for Shape Structures , 2017, ACM Trans. Graph..

[13]  Junyan Rong,et al.  Computer simulation of low-dose CT with clinical lung image database: a preliminary study , 2017, Medical Imaging.

[14]  A. Jemal,et al.  Cancer statistics, 2017 , 2017, CA: a cancer journal for clinicians.

[15]  Jimmy Ba,et al.  Adam: A Method for Stochastic Optimization , 2014, ICLR.

[16]  S ValenteIgor Rafael,et al.  Automatic 3D pulmonary nodule detection in CT images , 2016 .

[17]  Carl Doersch,et al.  Tutorial on Variational Autoencoders , 2016, ArXiv.