Xenobiotic metabolism in brain.
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[1] M. Boyd,et al. Flavin-containing monooxygenase mediated metabolism of psychoactive drugs by human brain microsomes , 1995, Brain Research.
[2] J R Cashman,et al. The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression. , 1994, Toxicology and applied pharmacology.
[3] G. Siest,et al. Localization of Drug‐Metabolizing Enzyme Activities to Blood‐Brain Interfaces and Circumventricular Organs , 1994, Journal of neurochemistry.
[4] J. Gustafsson,et al. Effect of ethanol on cytochrome P450 in the rat brain. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[5] S. Nelson,et al. The role of metabolic activation in drug toxicity. , 1994, Drug metabolism reviews.
[6] J. Miller,et al. Research in chemical carcinogenesis with Elizabeth Miller--a trail of discovery with our associates. , 1994, Drug metabolism reviews.
[7] H. Strobel,et al. Identification of cytochromes P450 1A2, 2A1, 2C7, 2E1 in rat glioma C6 cell line by RT-PCR and specific restriction enzyme digestion. , 1993, Biochemical and biophysical research communications.
[8] J. Gustafsson,et al. Role of brain cytochrome P450 in regulation of the level of anesthetic steroids in the brain. , 1993, Molecular pharmacology.
[9] C. J. Omiecinski,et al. Regional distribution and expression modulation of cytochrome P-450 and epoxide hydrolase mRNAs in the rat brain. , 1993, Molecular pharmacology.
[10] M. Komori. A novel P450 expressed at the high level in rat brain. , 1993, Biochemical and biophysical research communications.
[11] K. Tipton,et al. Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds , 1993, Journal of neurochemistry.
[12] C. J. Omiecinski,et al. Regiospecific expression of cytochrome P-450s and microsomal epoxide hydrolase in human brain tissue. , 1993, Journal of toxicology and environmental health.
[13] D. Williams,et al. Cerebral flavin-containing monooxygenase-mediated metabolism of antidepressants in brain: immunochemical properties and immunocytochemical localization. , 1993, The Journal of pharmacology and experimental therapeutics.
[14] J. Williams,et al. Differential effect of chronic nicotine administration on brain cytochrome P4501A1/2 and P4502E1. , 1993, Biochemical and biophysical research communications.
[15] R. Vijayalakshmi,et al. Rat brain flavin-containing monooxygenase: catalytic activity and sex-related difference , 1993 .
[16] P. Zaphiropoulos,et al. Identification of the major cytochrome P450s of subfamily 2C that are expressed in brain of female rats and in olfactory lobes of ethanol treated male rats. , 1993, Biochemical and biophysical research communications.
[17] J. Williams,et al. The Chronic Administration of Nicotine Induces Cytochrome P450 in Rat Brain , 1993, Journal of neurochemistry.
[18] M. Boyd,et al. Purification of multiple forms of cytochrome P450 from a human brain and reconstitution of catalytic activities. , 1993, Archives of Biochemistry and Biophysics.
[19] G. Siest,et al. Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain. , 1993, Biochemical pharmacology.
[20] M. Boyd,et al. Induction of brain cytochrome P-450IIE1 by chronic ethanol treatmen , 1993, Brain Research.
[21] M. J. Coon,et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. , 1993, DNA and cell biology.
[22] M. Boyd,et al. Characterization of a phenobarbital-inducible cytochrome P-450, NADPH-cytochrome P-450 reductase and reconstituted cytochrome P-450 mono-oxygenase system from rat brain. Evidence for constitutive presence in rat and human brain. , 1992, The Biochemical journal.
[23] P. Thomas,et al. Brain cytochrome P450 and testosterone metabolism by rat brain subcellular fractions: presence of cytochrome P450 3A immunoreactive protein in rat brain mitochondria. , 1992, Archives of biochemistry and biophysics.
[24] S. Shankar,et al. Microsomal cytochrome P450 in human brain regions. , 1992, Biochemical pharmacology.
[25] I. Paul,et al. Differential effects of cytochrome P-450 induction on ligand binding to σ receptors , 1992 .
[26] H. Strobel,et al. Reconstitution of the Brain Mixed Function Oxidase System: Purification of NADPH‐Cytochrome P450 Reductase and Partial Purification of Cytochrome P450 from Whole Rat Brain , 1992, Journal of neurochemistry.
[27] B. Summers,et al. Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease , 1992, The Lancet.
[28] W. Lichtensteiger,et al. Asymmetry of brain aromatase activity: region- and sex-specific developmental patterns. , 1992, Neuroendocrinology.
[29] J. Cashman,et al. Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[30] J. Falck,et al. Brain Synthesis and Cerebrovascular Action of Epoxygenase Metabolites of Arachidonic Acid , 1992, Journal of neurochemistry.
[31] G. Siest,et al. Chapter 49: Drug metabolizing enzymes in the rat pituitary gland , 1992 .
[32] L. Sultatos,et al. Biotransformation of the insecticide parathion by mouse brain. , 1992, Toxicology letters.
[33] P. Hall. Cytochrome P-450 C21scc: One enzyme with two actions: Hydroxylase and lyase , 1991, The Journal of Steroid Biochemistry and Molecular Biology.
[34] F. Oesch,et al. Mapping of phenytoin-inducible cytochrome P450 immunoreactivity in the mouse central nervous system , 1991, Neuroscience.
[35] J. Langston,et al. Biotransformation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes. , 1991, The Journal of pharmacology and experimental therapeutics.
[36] S. Povey,et al. Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1). , 1991, The Journal of biological chemistry.
[37] V. Ravindranath,et al. Presence of flavin-containing monooxygenase in rat brain. , 1991, Biochemical pharmacology.
[38] R. Tyndale,et al. Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6. , 1991, Molecular pharmacology.
[39] V. Ravindranath,et al. Administration of testosterone alleviates the constitutive sex difference in rat brain cytochrome P-450 , 1991, Neuroscience Letters.
[40] K. Reuhl,et al. Cellular and regional distribution of reduced glutathione in the nervous system of the rat: histochemical localization by mercury orange and o-phthaldialdehyde-induced histofluorescence. , 1991, Toxicology and applied pharmacology.
[41] N. Salem,et al. Lipoxygenation in rat brain? , 1991, Biochemical and biophysical research communications.
[42] J. Musacchio,et al. SKF 525-A and cytochrome P-450 ligands inhibit with high affinity the binding of [3H]dextromethorphan and sigma ligands to guinea pig brain. , 1991, Life sciences.
[43] M. Ingelman-Sundberg,et al. Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system , 1990, Neuroscience.
[44] S. Shankar,et al. Rat brain cytochromes P-450: catalytic, immunochemical properties and inducibility of multiple forms , 1990, Brain Research.
[45] G. Siest,et al. Distribution of cytochrome P450 activities towards alkoxyresorufin derivatives in rat brain regions, subcellular fractions and isolated cerebral microvessels. , 1990, Biochemical pharmacology.
[46] P. Seth,et al. Cytochrome P-450 dependent monooxygenases in neuronal and glial cells: inducibility and specificity. , 1990, Biochemical and biophysical research communications.
[47] S. Ross. Is the sigma opiate receptor a proadifen-sensitive subform of cytochrome P-450? , 1990, Pharmacology & toxicology.
[48] G. Snyder,et al. Role of arachidonic acid or its metabolites in growth-hormone-releasing factor-induced release of somatostatin from the median eminence. , 1990, Neuroendocrinology.
[49] B. Weiss,et al. Regional and subcellular distribution of cytochrome P-450-dependent drug metabolism in monkey brain: the olfactory bulb and the mitochondrial fraction have high levels of activity. , 1990, Biochemical and biophysical research communications.
[50] V. Ravindranath,et al. Preparation of brain microsomes with cytochrome P450 activity using calcium aggregation method. , 1990, Analytical biochemistry.
[51] S. Shankar,et al. NADPH cytochrome P-450 reductase in rat, mouse and human brain. , 1990, Biochemical pharmacology.
[52] R. Tyndale,et al. The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H]GBR-12935 binding proteins. , 1990, Archives of biochemistry and biophysics.
[53] S. Shankar,et al. Xenobiotic metabolism in human brain — presence of cytochrome P-450 and associated mono-oxygenases , 1989, Brain Research.
[54] V. Ravindranath,et al. High activity of cytochrome P-450-linked aminopyrine N-demethylase in mouse brain microsomes, and associated sex-related difference. , 1989, The Biochemical journal.
[55] V. Ravindranath,et al. Low glutathione levels in brain regions of aged rats , 1989, Neuroscience Letters.
[56] C. Kasper,et al. Quantitation of mRNAs specific for the mixed-function oxidase system in rat liver and extrahepatic tissues during development. , 1989, Archives of biochemistry and biophysics.
[57] H. Strobel,et al. Brain cytochromes P-450 are responsive to phenobarbital and tricyclic amines. , 1989, Pharmacological research.
[58] M. Maines,et al. Manganese-mediated increase in the rat brain mitochondrial cytochrome P-450 and drug metabolism activity: susceptibility of the striatum. , 1989, The Journal of pharmacology and experimental therapeutics.
[59] J. Gustafsson,et al. Regional Distribution of Cytochrome P‐450 in the Rat Brain: Spectral Quantitation and Contribution of P‐450b,e and P‐450c,d , 1988, Journal of neurochemistry.
[60] F. Oesch,et al. First evidence of cytochrome P-450 induction in the mouse brain by phenytoin , 1988, Neuroscience Letters.
[61] C. Köhler,et al. Immunohistochemical localization of cytochrome P-450 in the rat brain , 1988, Neuroscience Letters.
[62] O. Sugita,et al. Aromatization and 19-hydroxylation of androgens by rat brain cytochrome P-450. , 1988, Biochemical and biophysical research communications.
[63] G. Siest,et al. A new aspect of the protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels. , 1988, Life sciences.
[64] J. Gustafsson,et al. Cytochrome P-450 b and c in the rat brain and pituitary gland. , 1988, Molecular pharmacology.
[65] D. Ziegler,et al. Flavin-containing monooxygenases: catalytic mechanism and substrate specificities. , 1988, Drug metabolism reviews.
[66] E. Baulieu,et al. Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[67] U. Meyer,et al. MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation. , 1987, Biochemical and biophysical research communications.
[68] O. Sugita,et al. Partial purification of cytochrome P450 from rat brain and demonstration of estradiol hydroxylation. , 1987, Biochemical and biophysical research communications.
[69] M. Waterman,et al. Neurosteroids: cytochrome P-450scc in rat brain. , 1987, Science.
[70] G. Siest,et al. Quantitative measurement of cerebral cytochrome P-450 by second derivative spectrophotometry , 1987, Journal of Neuroscience Methods.
[71] G. Siest,et al. Brain mitochondrial cytochrome P-450scc: spectral and catalytic properties. , 1987, Archives of biochemistry and biophysics.
[72] G. Siest,et al. Ethoxyresorufin O-deethylase activity in rat brain subcellular fractions , 1987, Neuroscience Letters.
[73] D. Jacobowitz,et al. Immunohistochemical localization of cytochrome P-450 in rat brain , 1987, Neuroscience.
[74] F. Gonzalez,et al. Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. , 1986, The Journal of biological chemistry.
[75] A. Eisen,et al. ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, AND MOTONEURONE DISEASE: ABIOTROPIC INTERACTION BETWEEN AGEING AND ENVIRONMENT? , 1986, The Lancet.
[76] G. Siest,et al. Subcellular distribution of cytochrome P-450 in the brain , 1986, Brain Research.
[77] S. Paul,et al. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. , 1986, Science.
[78] M. Ames,et al. Metabolic activation of the serotonergic neurotoxin para-chloroamphetamine to chemically reactive intermediates by hepatic and brain microsomal preparations. , 1986, Biochemical pharmacology.
[79] D. Williams,et al. Rabbit lung flavin-containing monooxygenase. Purification, characterization, and induction during pregnancy. , 1985, Molecular pharmacology.
[80] E. Hodgson,et al. Catalytic activity and substrate specificity of the flavin-containing monooxygenase in microsomal systems: characterization of the hepatic, pulmonary and renal enzymes of the mouse, rabbit, and rat. , 1985, Archives of biochemistry and biophysics.
[81] E. Hodgson,et al. Identification of distinct hepatic and pulmonary forms of microsomal flavin-containing monooxygenase in the mouse and rabbit. , 1985, Biochemical and biophysical research communications.
[82] D. Liebler,et al. Enzymatic activation of chemicals to toxic metabolites. , 1985, Critical reviews in toxicology.
[83] D. Williams,et al. Rabbit lung flavin-containing monooxygenase is immunochemically and catalytically distinct from the liver enzyme. , 1984, Biochemical and biophysical research communications.
[84] M. Duffel,et al. Microsomal Flavin‐Containing Monooxygenase Activity in Rat Corpus Striatum , 1984, Journal of neurochemistry.
[85] J. Gustafsson,et al. Presence of NADPH-cytochrome P450 reductase in central catecholaminergic neurones , 1984, Nature.
[86] D. Jacobowitz,et al. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[87] M. Notelovitz,et al. Mestranol-induced hypertension: characterization of cytochrome P-450 dependent catechol estrogen formation in brain microsomes. , 1983, Biochemical pharmacology.
[88] A. Torvik,et al. Brain lesions in alcoholics A neuropathological study with clinical correlations , 1982, Journal of the Neurological Sciences.
[89] T. Nabeshima,et al. Effects of chronic administration of pentobarbital or morphine on the brain microsomal cytochrome P-450 system. , 1981, Biochemical pharmacology.
[90] H. Mukhtar,et al. Characterization of microsomal aryl hydrocarbon hydroxylase of rat brain. , 1981, The Journal of pharmacology and experimental therapeutics.
[91] M. R. Boyd,et al. Biochemical mechanisms in chemical-induced lung injury: roles of metabolic activation. , 1980, Critical reviews in toxicology.
[92] J. Monti,et al. Metabolism of the hallucinogen N,N-dimethyltryptamine in rat brain homogenates. , 1980, Biochemical pharmacology.
[93] D. Ziegler. Chapter 9 – Microsomal Flavin-Containing Monooxygenase: Oxygenation of Nucleophilic Nitrogen and Sulfur Compounds , 1980 .
[94] Sanford P. Markey,et al. Chronic parkinsonism secondary to intravenous injection of meperidine analogues , 1979, Psychiatry Research.
[95] F. Guengerich,et al. Immunological comparison of hepatic and extrahepatic cytochromes P-450. , 1979, Molecular pharmacology.
[96] E. Miller. Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address. , 1978, Cancer research.
[97] M. Hedden,et al. Behavioral effects and metabolic fate of N,N-dimethyltryptamine in mice pretreated with β-diethylaminoethyl-diphenylpropylacetate (SKF 525-A), iproniazid and chlorpromazine , 1978, Pharmacology Biochemistry and Behavior.
[98] S. Paul,et al. Catechol estrogen-forming enzyme of brain: demonstration of a cytochrome p450 monooxygenase. , 1977, Endocrinology.
[99] M. Boyd. Evidence for the Clara cell as a site of cytochrome P450-dependent mixed-function oxidase activity in lung , 1977, Nature.
[100] M. Ames,et al. Cytochrome P-450 and NADPH cytochrome c reductase in rat brain: formation of catechols and reactive catechol metabolites. , 1977, Biochemical and biophysical research communications.
[101] A. Kappas,et al. On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain , 1977, The Journal of experimental medicine.
[102] E. Domino,et al. Effects of iproniazid and tranylcypromine of the half-life of N,N-dimethyltryptamine in rat brain and liver. , 1976, Biochemical pharmacology.
[103] J. Fishman,et al. N-demethylation of morphine in rat brain is localised in sites with high opiate receptor content , 1976, Nature.
[104] B. Brodie,et al. Biochemical Mechanisms of Drug Toxicity , 1974 .
[105] H. Weissbach,et al. Studies on the mechanism of action of monoamine oxidase: metabolism of N,N-dimethyltryptamine and N,N-dimethyltryptamine-N-oxide. , 1962, Biochemistry.
[106] B. Howes,et al. The oxidative deamination of serotonin and other 3-(beta-aminoethyl)-indoles by monamine oxidase and the effect of these compounds on the deamination of tyramine. , 1953, Science.