Hierarchical Plasmonic Nanorods and Upconversion Core–Satellite Nanoassemblies for Multimodal Imaging‐Guided Combination Phototherapy

DNA-driven hierarchical core-satellite nanostructures with plasmonic gold nanorod dimers and upconversion nanoparticles are fabricated. Once the core-satellite structure is activated, combined photothermal therapy and photodynamic therapy are carried out under the guidance of upconversion luminesce, T1 -weighted magnetic resonance, photoacoustics, and computed tomography imaging of tumors in vivo, which exhibit the multifunctional biological applications of the DNA-based self-assemblies.

[1]  N. Seeman,et al.  Programmable materials and the nature of the DNA bond , 2015, Science.

[2]  Hua Zhang,et al.  Self-assembled chiral nanofibers from ultrathin low-dimensional nanomaterials. , 2015, Journal of the American Chemical Society.

[3]  Kai Yang,et al.  Facile preparation of multifunctional upconversion nanoprobes for multimodal imaging and dual-targeted photothermal therapy. , 2011, Angewandte Chemie.

[4]  Tianjiao Ji,et al.  Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy. , 2014, ACS nano.

[5]  S. Che,et al.  Gold nanorod@chiral mesoporous silica core-shell nanoparticles with unique optical properties. , 2013, Journal of the American Chemical Society.

[6]  M. Grzelczak,et al.  The relevance of light in the formation of colloidal metal nanoparticles. , 2014, Chemical Society reviews.

[7]  Liqiang Liu,et al.  Gold Core‐DNA‐Silver Shell Nanoparticles with Intense Plasmonic Chiroptical Activities , 2015 .

[8]  Mengya Liu,et al.  Surface plasmon resonance enhanced light absorption and photothermal therapy in the second near-infrared window. , 2014, Journal of the American Chemical Society.

[9]  Wei Feng,et al.  Upconversion luminescent materials: advances and applications. , 2015, Chemical reviews.

[10]  Jianlin Shi,et al.  Intranuclear Photosensitizer Delivery and Photosensitization for Enhanced Photodynamic Therapy with Ultralow Irradiance , 2014 .

[11]  Samuel Achilefu,et al.  Breaking the Depth Dependency of Phototherapy with Cerenkov Radiation and Low Radiance Responsive Nanophotosensitizers , 2015, Nature nanotechnology.

[12]  Yuliang Zhao,et al.  Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods. , 2014, Journal of the American Chemical Society.

[13]  R. Langer,et al.  Enhanced photothermal effect of plasmonic nanoparticles coated with reduced graphene oxide. , 2013, Nano letters.

[14]  Zhenpeng Qin,et al.  Thermophysical and biological responses of gold nanoparticle laser heating. , 2012, Chemical Society reviews.

[15]  Tuan Vo-Dinh,et al.  TAT peptide-functionalized gold nanostars: enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance. , 2012, Journal of the American Chemical Society.

[16]  Changlong Hao,et al.  Assembled plasmonic asymmetric heterodimers with tailorable chiroptical response. , 2014, Small.

[17]  Chad A Mirkin,et al.  Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates , 2013, Proceedings of the National Academy of Sciences.

[18]  Jibin Song,et al.  Self-assembled plasmonic vesicles of SERS-encoded amphiphilic gold nanoparticles for cancer cell targeting and traceable intracellular drug delivery. , 2012, Journal of the American Chemical Society.

[19]  Si Li,et al.  Up-conversion fluorescence "off-on" switch based on heterogeneous core-satellite assembly for thrombin detection. , 2015, Biosensors & bioelectronics.

[20]  Mingyuan Gao,et al.  Magnetic/upconversion fluorescent NaGdF4:Yb,Er nanoparticle-based dual-modal molecular probes for imaging tiny tumors in vivo. , 2013, ACS nano.

[21]  C. Mirkin,et al.  Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence. , 2015, Chemical reviews.

[22]  Pengfei Wang,et al.  Red‐Emissive Carbon Dots for Fluorescent, Photoacoustic, and Thermal Theranostics in Living Mice , 2015, Advanced materials.

[23]  Dongsheng Liu,et al.  Improving the yield of mono-DNA-functionalized gold nanoparticles through dual steric hindrance. , 2011, Journal of the American Chemical Society.

[24]  Yonggang Ke,et al.  Au nanorod helical superstructures with designed chirality. , 2015, Journal of the American Chemical Society.

[25]  Liang Cheng,et al.  Functional nanomaterials for phototherapies of cancer. , 2014, Chemical reviews.

[26]  Liguang Xu,et al.  Unusual Circularly Polarized Photocatalytic Activity in Nanogapped Gold–Silver Chiroplasmonic Nanostructures , 2015 .

[27]  Zhuang Liu,et al.  Engineering of Multifunctional Nano‐Micelles for Combined Photothermal and Photodynamic Therapy Under the Guidance of Multimodal Imaging , 2014 .

[28]  Yuliang Zhao,et al.  Smart Albumin‐Biomineralized Nanocomposites for Multimodal Imaging and Photothermal Tumor Ablation , 2015, Advanced materials.

[29]  H. Dai,et al.  Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy. , 2015, Chemical reviews.

[30]  Tymish Y. Ohulchanskyy,et al.  Photodynamic therapy by in situ nonlinear photon conversion , 2014, Nature Photonics.

[31]  Jianfang Wang,et al.  Understanding the photothermal conversion efficiency of gold nanocrystals. , 2010, Small.

[32]  Huanan Zhang,et al.  Chiral plasmonics of self-assembled nanorod dimers , 2013, Scientific Reports.

[33]  Peter Nordlander,et al.  Plasmon-induced hot carrier science and technology. , 2015, Nature nanotechnology.

[34]  Zhe Wang,et al.  Single Continuous Wave Laser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitizer‐Functionalized Gold Nanostars , 2013, Advanced materials.

[35]  Taeghwan Hyeon,et al.  Theranostic Probe Based on Lanthanide‐Doped Nanoparticles for Simultaneous In Vivo Dual‐Modal Imaging and Photodynamic Therapy , 2012, Advanced materials.

[36]  Qiangbin Wang,et al.  Double-walled Au nanocage/SiO2 nanorattles: integrating SERS imaging, drug delivery and photothermal therapy. , 2015, Small.

[37]  Guanghui Ma,et al.  Theranostic Gold Nanomicelles made from Biocompatible Comb‐like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance , 2015, Advanced materials.

[38]  W. Chan,et al.  DNA assembly of nanoparticle superstructures for controlled biological delivery and elimination , 2014, Nature nanotechnology.

[39]  Amit Kumar,et al.  Oxidative nanopeeling chemistry-based synthesis and photodynamic and photothermal therapeutic applications of plasmonic core-petal nanostructures. , 2014, Journal of the American Chemical Society.

[40]  Liguang Xu,et al.  Regiospecific plasmonic assemblies for in situ Raman spectroscopy in live cells. , 2012, Journal of the American Chemical Society.

[41]  Huangxian Ju,et al.  Cell-specific and pH-activatable rubyrin-loaded nanoparticles for highly selective near-infrared photodynamic therapy against cancer. , 2013, Journal of the American Chemical Society.

[42]  Zhening Zhu,et al.  Controllable optical activity of gold nanorod and chiral quantum dot assemblies. , 2013, Angewandte Chemie.

[43]  C. Mirkin,et al.  Antibody-linked spherical nucleic acids for cellular targeting. , 2012, Journal of the American Chemical Society.

[44]  Liguang Xu,et al.  SERS Encoded Silver Pyramids for Attomolar Detection of Multiplexed Disease Biomarkers , 2015, Advanced materials.

[45]  M. S. El-shall,et al.  Ultrasmall gold nanoparticles anchored to graphene and enhanced photothermal effects by laser irradiation of gold nanostructures in graphene oxide solutions. , 2013, ACS nano.

[46]  Liguang Xu,et al.  Self-assembly of chiral nanoparticle pyramids with strong R/S optical activity. , 2012, Journal of the American Chemical Society.

[47]  Liguang Xu,et al.  Attomolar DNA detection with chiral nanorod assemblies , 2013, Nature Communications.

[48]  A one-step homogeneous plasmonic circular dichroism detection of aqueous mercury ions using nucleic acid functionalized gold nanorods. , 2012, Chemical communications.

[49]  Hao Zhang,et al.  Polypyrrole-coated chainlike gold nanoparticle architectures with the 808 nm photothermal transduction efficiency up to 70%. , 2014, ACS applied materials & interfaces.

[50]  Mostafa A. El-Sayed,et al.  Probing the unique dehydration-induced structural modifications in cancer cell DNA using surface enhanced Raman spectroscopy. , 2013, Journal of the American Chemical Society.

[51]  B. Ren,et al.  Enhancing the Photothermal Stability of Plasmonic Metal Nanoplates by a Core‐Shell Architecture , 2011, Advanced materials.

[52]  E. A. Waters,et al.  Multimeric Near IR–MR Contrast Agent for Multimodal In Vivo Imaging , 2015, Journal of the American Chemical Society.

[53]  F. Simmel,et al.  DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response , 2011, Nature.

[54]  W. Liu,et al.  New insight into the role of gold nanoparticles in Au@CdS core-shell nanostructures for hydrogen evolution. , 2014, Small.

[55]  Chun‐Sing Lee,et al.  A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation , 2014, Nature Communications.

[56]  Wei Zhou,et al.  Facile synthesis of pentacle gold–copper alloy nanocrystals and their plasmonic and catalytic properties , 2014, Nature Communications.

[57]  Y. Liu,et al.  Core–Shell Upconversion Nanoparticle@Metal–Organic Framework Nanoprobes for Luminescent/Magnetic Dual‐Mode Targeted Imaging , 2015, Advanced materials.

[58]  F. Fang,et al.  Anchoring Group Effects of Surface Ligands on Magnetic Properties of Fe3O4 Nanoparticles: Towards High Performance MRI Contrast Agents , 2014, Advanced materials.

[59]  Muthu Kumara Gnanasammandhan,et al.  In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers , 2012, Nature Medicine.

[60]  Jong Hwa Jung,et al.  Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting. , 2015, Journal of the American Chemical Society.

[61]  Wei Li,et al.  Probing and controlling photothermal heat generation in plasmonic nanostructures. , 2013, Nano letters.

[62]  Clare C. Byeon,et al.  Tumor regression in vivo by photothermal therapy based on gold-nanorod-loaded, functional nanocarriers. , 2011, ACS nano.

[63]  Rujia Zou,et al.  Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. , 2011, ACS nano.