论文信息 - Non-invasive imaging of activation times during drug inducedconduction changes

Non-invasive imaging of activation times during drug inducedconduction changes

The feasibility was studied of monitoring changes in the activation sequence of the heart on the basis of potentials observed on the body surface potentials during a clinical procedure involving the infusion of a sodium channel blocker. The changes in the activation pattern were derived from an inverse procedure (activation time imaging). The results suggest that this is indeed possible, in spite of the fact that the number of ECGs used in the inverse procedure was 65. The quality of the results was attributed to recent improvements in the algorithm performing the imaging procedure.

[1] A. van Oosterom,et al. The intra-myocardial distance function used in inverse computations of the timing of depolarization and repolarization , 2005 .

[2] A. van Oosterom,et al. Model Studies with the Inversely Calculated lsochrones of Ventricular Depolarization , 1984, IEEE Transactions on Biomedical Engineering.

[3] A. van Oosterom,et al. A Parametrized Description of Transmembrane Potential used in Forward and Inverse Procedures , 2005 .

[4] Y. Rudy,et al. Noninvasive Electrocardiographic Imaging , 1999 .

[5] M. Schocke,et al. Atrial Noninvasive Activation Mapping of Paced Rhythm Data , 2003, Journal of cardiovascular electrophysiology.

[6] Martin Borggrefe,et al. Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome. , 2005, Heart rhythm.

[7] G. Huiskamp,et al. The depolarization sequence of the human heart surface computed from measured body surface potentials , 1988, IEEE Transactions on Biomedical Engineering.

[8] Fred Greensite,et al. Myocardial activation imaging: a new theorem and its implications , 1995, Proceedings of 17th International Conference of the Engineering in Medicine and Biology Society.